ERC2 and PPFIA1

Number of citations of the paper that reports this interaction (PMID 12923177)
33

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		ERC2	PPFIA1
Gene Name		ELKS/RAB6-interacting/CAST family member 2	protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytoskeleton Cell Junction Growth Cone Presynaptic Membrane Presynaptic Active Zone	Cytoplasm Cytosol Focal Adhesion Presynaptic Active Zone
	Molecular Function	Protein Binding	Signal Transducer Activity Protein Binding
	Biological Process		Cell-matrix Adhesion Signal Transduction Synaptic Transmission Neurotransmitter Secretion Glutamate Secretion Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways			Dopamine Neurotransmitter Release Cycle Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Serotonin Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 21057379) Hip geometry ( 17903296)
Protein-Protein Interactions		8 interactors: BSN MYB PCLO PPFIA1 PPFIA2 PPFIA3 PPFIA4 RIMS1	25 interactors: AGTPBP1 CAST CCNH CEP70 DTNB ERC1 ERC2 FAM161A GIT1 MBIP NCOA2 NDN PPFIA2 PPFIA3 PPFIBP1 PPFIBP2 PPP2R5D PTPRC PTPRD PTPRF PTPRG PTPRS TNNT1 TXLNA YWHAG
Entrez ID		26059	8500
HPRD ID		10810	11451
Ensembl ID		ENSG00000187672	ENSG00000131626
Uniprot IDs		O15083	B3KVS8 Q13136
PDB IDs
Enriched GO Terms of Interacting Partners?		Glutamate Secretion Neurotransmitter Secretion Regulation Of Neurotransmitter Levels Neurotransmitter Transport Acid Secretion Dicarboxylic Acid Transport Synaptic Transmission Amino Acid Transport Cell-cell Signaling Secretion By Cell Secretion Carboxylic Acid Transport Organic Acid Transport Organic Anion Transport Anion Transport Ion Transport Establishment Of Localization In Cell Cellular Localization Transport Synaptic Vesicle Exocytosis Regulation Of Neuronal Synaptic Plasticity Signaling Cell Communication Synaptic Vesicle Transport Regulation Of Synaptic Plasticity Cell-matrix Adhesion Positive Regulation Of Inhibitory Postsynaptic Membrane Potential Establishment Of Vesicle Localization Vesicle Localization Cell-substrate Adhesion Calcium Ion-dependent Exocytosis Of Neurotransmitter Negative Regulation Of Stress Fiber Assembly Regulation Of Cellular Localization Negative Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Histone H3-K9 Methylation Regulation Of Short-term Neuronal Synaptic Plasticity Regulation Of Synaptic Transmission Regulation Of Inhibitory Postsynaptic Membrane Potential Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane Establishment Of Organelle Localization Exocytosis Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Protein Localization To Plasma Membrane CAMP-mediated Signaling Regulation Of Histone H3-K4 Methylation Organelle Localization Cellular Response To Interleukin-6 Positive Regulation Of T-helper Cell Differentiation Cyclic-nucleotide-mediated Signaling Regulation Of Long-term Neuronal Synaptic Plasticity	Peptidyl-tyrosine Dephosphorylation Protein Dephosphorylation Dephosphorylation Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Signaling Cell Communication Cell Cycle Phase Transition Nervous System Development G2/M Transition Of Mitotic Cell Cycle Glutamate Secretion Cellular Protein Modification Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Transcription Initiation From RNA Polymerase I Promoter Generation Of Neurons Transcription From RNA Polymerase I Promoter Neurogenesis Cell Adhesion Signal Transduction Negative Regulation Of Protein Kinase Activity Inactivation Of MAPK Activity Involved In Osmosensory Signaling Pathway Negative Regulation Of Kinase Activity Acid Secretion Mitotic Cell Cycle Phase Transition Cellular Response To Stimulus Immunoglobulin Biosynthetic Process Positive Regulation Of Hematopoietic Stem Cell Migration DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transferase Activity Phosphate-containing Compound Metabolic Process Dicarboxylic Acid Transport DNA-templated Transcription, Elongation Cellular Protein Metabolic Process Negative Regulation Of Protein Phosphorylation Neuron Differentiation C-terminal Protein Deglutamylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Response To Stimulus Neurotransmitter Secretion Cell Surface Receptor Signaling Pathway Developmental Process Histone Acetylation Negative Regulation Of Catalytic Activity Cerebellum Development Regulation Of Kinase Activity Negative Regulation Of Phosphorylation
Tagcloud ?			11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways
Tagcloud (Difference) ?			11q13 aberrations acgh aiming amplicon apart band breakpoints candidates ccnd1 chosen chr comprised copies cttn distinguish fadd gain homogeneously laryngeal microarray oncogene oncogenes oraov1 q13 rearrangements reinvestigated sevenfold ways
Tagcloud (Intersection) ?