ZNF521 and EBF1

Number of citations of the paper that reports this interaction (PMID 14630787)
19

Data Source:
HPRD (in vitro)

		ZNF521	EBF1
Gene Name		zinc finger protein 521	early B-cell factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Nucleus
	Molecular Function	DNA Binding Protein Domain Specific Binding Metal Ion Binding	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Metal Ion Binding Protein Dimerization Activity C2H2 Zinc Finger Domain Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Multicellular Organismal Development Cell Differentiation	Transcription, DNA-templated Multicellular Organismal Development Positive Regulation Of Transcription, DNA-templated
Pathways			Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998)	Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Blood pressure ( 21909110) Breast cancer ( 23535729 23535733) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Obesity-related traits ( 23251661) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		5 interactors: EBF1 GATA1 LYST SMAD1 SMAD4	6 interactors: ATPAF2 CREBBP HOMEZ PAX5 ZNF423 ZNF521
Entrez ID		25925	1879
HPRD ID		18350	01256
Ensembl ID		ENSG00000198795	ENSG00000164330
Uniprot IDs		J3KTI4 Q96K83	Q9UH73
PDB IDs			3LYR 3MQI
Enriched GO Terms of Interacting Partners?		SMAD Protein Complex Assembly Cell Fate Commitment Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process BMP Signaling Pathway Embryonic Pattern Specification Wound Healing Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Negative Regulation Of Cell Proliferation Ureteric Bud Development Mesonephric Tubule Development Mesonephric Epithelium Development Response To Wounding Mesonephros Development Transforming Growth Factor Beta Receptor Signaling Pathway Mesoderm Development Basophil Differentiation Eosinophil Fate Commitment Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Nephrogenic Mesenchyme Morphogenesis Mast Cell Secretory Granule Organization Kidney Epithelium Development Transcription, DNA-templated Positive Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Cell Differentiation Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Gastrulation Eosinophil Differentiation Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Transcriptional Activation By Promoter-enhancer Looping Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Regulation Of Ossification Positive Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Formation Involved In Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Definitive Erythrocyte Differentiation Embryo Development Regulation Of Binding Endocardial Cell Differentiation Endosome Transport Via Multivesicular Body Sorting Pathway Primary MiRNA Processing RNA Metabolic Process Osteoblast Fate Commitment	Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Notch Signaling Pathway Negative Regulation Of Transcription From RNA Polymerase II Promoter Proton-transporting ATP Synthase Complex Assembly N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Germ-line Stem Cell Maintenance Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Histone H3-K9 Methylation N-terminal Protein Amino Acid Acetylation Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Histone Methylation Positive Regulation Of Gene Expression Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia N-terminal Protein Amino Acid Modification Regulation Of Cellular Response To Heat Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of BMP Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Histone Methylation Regulation Of Metabolic Process Regulation Of DNA-templated Transcription In Response To Stress Skeletal Muscle Cell Differentiation Cellular Response To Heat Multicellular Organismal Development Transcription From RNA Polymerase II Promoter
Tagcloud ?			collaborate concert coordinate cues decades e2a epigenetic establish establishing extrinsic fate fates foxo1 guide ikaros landscape lineage lineages lock loops lymphopoiesis modifiers modify pax permissive prime pu repress runx1
Tagcloud (Difference) ?			collaborate concert coordinate cues decades e2a epigenetic establish establishing extrinsic fate fates foxo1 guide ikaros landscape lineage lineages lock loops lymphopoiesis modifiers modify pax permissive prime pu repress runx1
Tagcloud (Intersection) ?