NIPBL and CBX5

Number of citations of the paper that reports this interaction (PMID 15882967)
57

Data Source:
BioGRID (unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)

		NIPBL	CBX5
Gene Name		Nipped-B homolog (Drosophila)	chromobox homolog 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm SMC Loading Complex Extracellular Vesicular Exosome	Histone Deacetylase Complex Kinetochore Nucleus Nuclear Envelope Nucleoplasm Nuclear Heterochromatin Nucleolus Chromocenter PML Body Transcriptional Repressor Complex Nuclear Pericentric Heterochromatin Histone Methyltransferase Complex
	Molecular Function	Chromatin Binding Protein Binding Protein C-terminus Binding Mediator Complex Binding Histone Deacetylase Binding Protein N-terminus Binding Chromo Shadow Domain Binding	Chromatin Binding Protein Binding Protein Binding, Bridging Methylated Histone Binding Protein Homodimerization Activity Histone Deacetylase Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Metanephros Development Heart Morphogenesis Outflow Tract Morphogenesis Cellular Response To DNA Damage Stimulus Mitotic Sister Chromatid Cohesion Brain Development Sensory Perception Of Sound Stem Cell Maintenance Positive Regulation Of Histone Deacetylation Maintenance Of Mitotic Sister Chromatid Cohesion Cellular Protein Localization Embryonic Forelimb Morphogenesis Forelimb Morphogenesis External Genitalia Morphogenesis Positive Regulation Of Multicellular Organism Growth Ear Morphogenesis Regulation Of Hair Cycle Fat Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Embryonic Development Embryonic Digestive Tract Morphogenesis Developmental Growth Eye Morphogenesis Regulation Of Developmental Growth Embryonic Viscerocranium Morphogenesis Cognition Face Morphogenesis Gall Bladder Development Uterus Morphogenesis Cellular Response To X-ray	Blood Coagulation Viral Process Negative Regulation Of Transcription, DNA-templated
Pathways		Mitotic Telophase/Cytokinesis Cohesin Loading onto Chromatin Cell Cycle, Mitotic M Phase	Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Mean platelet volume ( 22139419)
Protein-Protein Interactions		8 interactors: CBX3 CBX5 CDK6 DBN1 HINFP MAU2 PRSS23 SP100	50 interactors: ARHGDIA ARL5A BCL11B CBX1 CBX3 CHAF1A DNMT3B DSN1 FSHR GOLGA8EP HDAC4 HDAC5 HDAC9 HIST1H1B HIST1H1E HIST2H3A HIST3H2A HIST3H2BB HIST3H3 HIST4H4 INCENP LBR LRIF1 MBD1 MCC MIS12 MKI67 NIPBL NR2F1 NSL1 PRR14 RPSA SMARCA4 SP1 SP100 SRPK1 SRPK2 STAM2 SUB1 SUV39H1 SUV39H2 TAF4 TCEB1 TCEB3B TRIM24 TRIM28 VPS28 WHSC1L1 XRCC6 XRN1
Entrez ID		25836	23468
HPRD ID		10560	05131
Ensembl ID		ENSG00000164190	ENSG00000094916
Uniprot IDs		Q6KC79	P45973
PDB IDs			3FDT 3I3C
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cell Dedifferentiation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Fas Signaling Pathway Cell Communication By Chemical Coupling Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Maintenance Of Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Chromatin Remodeling Negative Regulation Of Protein Export From Nucleus Negative Regulation Of Cellular Senescence Negative Regulation Of Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Chromosome Organization Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator DNA Damage Response, Signal Transduction Resulting In Transcription Hematopoietic Stem Cell Differentiation Cell Communication By Electrical Coupling Negative Regulation Of Cell Aging Mitotic Sister Chromatid Cohesion Dentate Gyrus Development Type B Pancreatic Cell Development Negative Regulation Of Viral Transcription Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Astrocyte Development Type B Pancreatic Cell Differentiation Cell Cycle Lateral Ventricle Development Enteroendocrine Cell Differentiation Cell Division	Chromosome Organization Chromatin Organization Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Organelle Organization Nucleobase-containing Compound Metabolic Process RNA Biosynthetic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Chromatin Modification Regulation Of Gene Expression, Epigenetic Histone H3-K9 Modification Negative Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Positive Regulation Of Gene Expression Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Viral Process Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-lysine Modification Gene Silencing Histone Modification Cellular Macromolecule Biosynthetic Process Chromatin Remodeling Macromolecule Biosynthetic Process DNA Methylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Process Nucleosome Organization Regulation Of Metabolic Process DNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter DNA Modification
Tagcloud ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem novo partitioning rad21 recursive separase smc1a smc3 undetected	1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri
Tagcloud (Difference) ?		12q13 1p36 ankrd11 cdls cleaves cohesin cornelia deeper discriminating encompassing espl1 exome filtering hdac8 intellectual intronic kbg lange merits mosaic multisystem novo partitioning rad21 recursive separase smc1a smc3 undetected	1alpha aberrant abstract addressing comprehensively deregulation di diagnostics dual emerging encoded epigenetics evolutionary forming h3k9me2 hallmark heterochromatin highlights hp1alpha mechanistic metastasis methylated mitotic networks overview serves sight therapeutics tri
Tagcloud (Intersection) ?