TXN2 and SHARPIN

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TXN2	SHARPIN
Gene Name		thioredoxin 2	SHANK-associated RH domain interactor
Image
Gene Ontology Annotations	Cellular Component	Nucleolus Mitochondrion Mitochondrial Matrix Dendrite Neuronal Cell Body	Nucleus Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Cell Junction Dendrite LUBAC Complex
	Molecular Function	Peptide-methionine (S)-S-oxide Reductase Activity Protein Disulfide Oxidoreductase Activity Protein Complex Binding Peptide-methionine (R)-S-oxide Reductase Activity	Protein Binding Zinc Ion Binding Polyubiquitin Binding Protein Complex Binding Identical Protein Binding
	Biological Process	Response To Reactive Oxygen Species Response To Hypoxia Glycerol Ether Metabolic Process Response To Nutrient Response To Hormone Response To Glucose Response To Organic Cyclic Compound Cellular Response To Nutrient Levels Response To Drug Cell Redox Homeostasis Response To Axon Injury Oxidation-reduction Process	Mitochondrion Organization Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Inflammatory Response Protein Homooligomerization Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS
Protein-Protein Interactions		34 interactors: AGTRAP ALDOB AP2B1 CCDC114 DCTD FAM9B GPRASP2 KRT18 KRT40 MAGEA11 MAPRE2 MAPRE3 MLH1 MRFAP1L1 MTUS2 PPCDC PSME3 RABAC1 RABGEF1 RBM45 REEP6 RPIA SCYL3 SHARPIN SSNA1 STUB1 THAP1 TIFA TRIM21 TRIP6 UCHL5 VIM VPS52 ZBTB14	10 interactors: ITGA1 ITGA2 ITGAD ITGAL ITGAM SHANK1 SHANK2 TXN2 UBC UBE2D3
Entrez ID		25828	81858
HPRD ID		07161	15463
Ensembl ID		ENSG00000100348	ENSG00000179526
Uniprot IDs		B4DX69 Q99757	Q6PJD5 Q9H0F6
PDB IDs		1UVZ 1W4V 1W89	4EMO
Enriched GO Terms of Interacting Partners?		Protein Polyubiquitination Cell Cycle Protein Ubiquitination Protein Modification By Small Protein Conjugation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Protein Autoubiquitination Negative Regulation Of Kit Signaling Pathway Meiotic Metaphase I Plate Congression Golgi To Plasma Membrane CFTR Protein Transport Meiotic Spindle Midzone Assembly Regulation Of Proteasomal Protein Catabolic Process I-kappaB Kinase/NF-kappaB Signaling Signal Transduction Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Chaperone-mediated Protein Complex Assembly Negative Regulation Of Mitotic Recombination Positive Regulation Of Microtubule Plus-end Binding Fructose Catabolic Process Embryonic Ectodermal Digestive Tract Development Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Viral Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Ubiquitin-protein Transferase Activity Execution Phase Of Apoptosis Nucleotide Metabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Protein Deubiquitination Regulation Of CD40 Signaling Pathway Protein Linear Polyubiquitination Positive Regulation Of Cell Cycle Apoptotic Process Signaling Nicotinamide Nucleotide Metabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Recombination Pentose-phosphate Shunt, Non-oxidative Branch Fructose 1,6-bisphosphate Metabolic Process Male Meiosis Chromosome Segregation Positive Regulation Of Viral Entry Into Host Cell Programmed Cell Death Cell Communication Protein Complex Assembly Cell Cycle Process Regulation Of Cytokine-mediated Signaling Pathway Cell Death Nucleobase-containing Small Molecule Metabolic Process Death Negative Regulation Of Interleukin-6 Secretion Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway	Integrin-mediated Signaling Pathway Activated T Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization T Cell Proliferation Toll-like Receptor 4 Signaling Pathway Response To Hypoxia Response To Wounding Toll-like Receptor Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation Positive Regulation Of Immune System Process Vocalization Behavior Blood Coagulation Pattern Recognition Receptor Signaling Pathway Hemostasis Innate Immune Response-activating Signal Transduction Cell Communication Activation Of Innate Immune Response Cell-matrix Adhesion Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Innate Immune Response Cell Surface Receptor Signaling Pathway Cell Adhesion Cellular Extravasation Regulation Of Body Fluid Levels Positive Regulation Of Phosphatase Activity Wound Healing Cell-substrate Adhesion Immune System Process Immune Response Regulation Of Immune System Process Leukocyte Migration Response To Stress Regulation Of Innate Immune Response Social Behavior Cell Proliferation Negative Regulation Of Type I Interferon Production Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Dephosphorylation Negative Regulation Of ERBB Signaling Pathway T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Neutrophil Chemotaxis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Neutrophil Migration Regulation Of DNA-templated Transcription In Response To Stress
Tagcloud ?			1l chain composed conjugation consists deeply elusive fluorescein fret fungal gliotoxin hoil hoip hts ibr linear lubac malignancy metabolite modulator nemo ring searched selectively tb3 termini though throughput ubiquitin
Tagcloud (Difference) ?			1l chain composed conjugation consists deeply elusive fluorescein fret fungal gliotoxin hoil hoip hts ibr linear lubac malignancy metabolite modulator nemo ring searched selectively tb3 termini though throughput ubiquitin
Tagcloud (Intersection) ?