LSM4 and LSM8

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		LSM4	LSM8
Gene Name		LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)	LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Spliceosomal Complex U6 SnRNP Cytosol Small Nuclear Ribonucleoprotein Complex	Spliceosomal Complex U4/U6 X U5 Tri-snRNP Complex
	Molecular Function	Protein Binding Poly(A) RNA Binding	Protein Binding U6 SnRNA Binding U6 SnRNA 3'-end Binding Poly(A) RNA Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Processing RNA Splicing Gene Expression Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay	MRNA Splicing, Via Spliceosome
Pathways		mRNA decay by 5' to 3' exoribonuclease Deadenylation-dependent mRNA decay
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: CALCOCO2 COX5B IKZF1 L3MBTL3 LSM1 LSM7 LSM8 NMI PLEKHA5 PSTPIP1 RHOXF2 SLC22A2 SMIM14 SMN1 SMU1 SNRPE TOE1 TOP1 XRN1 ZBTB10	49 interactors: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FAM63A FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM4 LSM5 LSM6 LSM7 MGA MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPT10 SEPT5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		25804	51691
HPRD ID		06284	06288
Ensembl ID		ENSG00000130520
Uniprot IDs		Q9Y4Z0 U3KQK1	A4D0W0 O95777
PDB IDs
Enriched GO Terms of Interacting Partners?		Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic MRNA Metabolic Process RNA Splicing Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay MRNA Processing RNA Metabolic Process Histone MRNA Catabolic Process RNA Splicing, Via Transesterification Reactions Gene Expression RNA Processing Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nitrogen Compound Metabolic Process Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Positive Regulation Of Neutrophil Differentiation Spliceosomal Complex Assembly Aromatic Compound Catabolic Process NcRNA Metabolic Process Cellular Metabolic Process Nuclear MRNA Surveillance Positive Regulation Of NK T Cell Differentiation RNA Surveillance Choline Transport Deadenylation-dependent Decapping Of Nuclear-transcribed MRNA Positive Regulation Of Granulocyte Differentiation Ribonucleoprotein Complex Assembly Chromatin Modification RRNA Catabolic Process Embryonic Cleavage Erythrocyte Maturation	Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process MRNA Metabolic Process MRNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Catabolic Process Nucleobase-containing Compound Metabolic Process Aromatic Compound Catabolic Process RNA Splicing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process MRNA Processing RNA Processing Catabolic Process Gene Expression RNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Cellular Macromolecule Catabolic Process Ribonucleoprotein Complex Biogenesis Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Metabolic Process Histone MRNA Metabolic Process Pentose Biosynthetic Process Metabolic Process Histone MRNA Catabolic Process Dosage Compensation By Inactivation Of X Chromosome Spliceosomal Complex Assembly Dosage Compensation Ribonucleoprotein Complex Assembly Ribosome Biogenesis Pentose-phosphate Shunt Glyceraldehyde-3-phosphate Metabolic Process Nucleobase-containing Small Molecule Metabolic Process Glucose 6-phosphate Metabolic Process RRNA Processing NcRNA Metabolic Process Starch Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Response To Type III Interferon Dolichol Biosynthetic Process NADP Metabolic Process RRNA Metabolic Process Spliceosomal SnRNP Assembly Carbohydrate Biosynthetic Process D-gluconate Metabolic Process Response To Vitamin B2
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