GCA and LCP1

Number of citations of the paper that reports this interaction (PMID 11279160)
9

Data Source:
HPRD (in vitro, in vivo)

		GCA	LCP1
Gene Name		grancalcin, EF-hand calcium binding protein	lymphocyte cytosolic protein 1 (L-plastin)
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Extracellular Vesicular Exosome	Stress Fiber Ruffle Phagocytic Cup Extracellular Space Cytoplasm Cytosol Actin Filament Plasma Membrane Focal Adhesion Actin Cytoskeleton Filopodium Actin Filament Bundle Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Actin Binding Calcium Ion Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Proteolysis Membrane Fusion	T Cell Activation Involved In Immune Response Protein Kinase A Signaling Cell Migration Organ Regeneration Regulation Of Intracellular Protein Transport Wound Healing, Spreading Of Cells Actin Filament Bundle Assembly
Pathways
Drugs
Diseases
GWAS			Non-alcoholic fatty liver disease histology (other) ( 23213074)
Protein-Protein Interactions		5 interactors: ATXN1 LCP1 MAGEA8 RBFOX1 SRI	5 interactors: AIF1 ATXN2 CNN3 GCA PRKACA
Entrez ID		25801	3936
HPRD ID		06122	01082
Ensembl ID			ENSG00000136167
Uniprot IDs		P28676	P13796
PDB IDs		1F4O 1F4Q 1K94 1K95	2D85
Enriched GO Terms of Interacting Partners?		Intracellular Sequestering Of Iron Ion Protein Kinase A Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Intracellular Protein Transport Regulation Of Membrane Potential Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Relaxation Of Muscle Negative Regulation Of Heart Rate Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Sequestering Of Metal Ion Regulation Of Cell Communication By Electrical Coupling	Positive Regulation Of Muscle Hyperplasia Positive Regulation Of Dense Core Granule Biogenesis Positive Regulation Of Chemotaxis Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Behavior Regulation Of Chemotaxis Histone H3-T6 Phosphorylation Negative Regulation Of Smooth Muscle Cell Chemotaxis Membrane Organization Regulation Of Behavior Positive Regulation Of Smooth Muscle Cell Chemotaxis Cellular Response To Morphine Positive Regulation Of Cell Cycle Process Cellular Response To Isoquinoline Alkaloid Peptidyl-serine Autophosphorylation Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Cellular Response To Parathyroid Hormone Stimulus Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Positive Regulation Of Cell Cycle Organelle Organization Positive Regulation Of Cell Migration Desmosome Assembly Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Negative Regulation Of Receptor Internalization Regulation Of Tight Junction Assembly Cytoplasmic MRNA Processing Body Assembly Positive Regulation Of Locomotion Positive Regulation Of Monocyte Chemotaxis Negative Regulation Of Glucose Import Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Positive Regulation Of Macrophage Differentiation Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Desmosome Organization Response To Parathyroid Hormone Negative Regulation Of Transport Cellular Response To Organic Cyclic Compound Phagocytosis, Engulfment Positive Regulation Of Protein Export From Nucleus Microglial Cell Activation Regulation Of Mitotic Cell Cycle Regulation Of Monocyte Chemotaxis Cerebellar Purkinje Cell Differentiation Cell Communication By Electrical Coupling Cellular Response To Hydroperoxide Activation Of Protein Kinase A Activity Stress Granule Assembly
Tagcloud ?		acanthamoeba acquisition agc ancestral arrays cag clustering coevolution coincided duplications enlargement evolutionary falciparum incorporate insects lineages metazoans motifs nematodes opa overrepresented propensity ribosomal rnas slippage tbp underrepresentation vertebrates wheat	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Difference) ?		acanthamoeba acquisition agc ancestral arrays cag clustering coevolution coincided duplications enlargement evolutionary falciparum incorporate insects lineages metazoans motifs nematodes opa overrepresented propensity ribosomal rnas slippage tbp underrepresentation vertebrates wheat	cct5 cd68 ddx5 enterovirus ft1dm fulminant helicase hnrnph1 hspa1l infiltrated inflamed insulitis iqgap1 lamin lmnb1 microdissection moesin msn pdg phosphogluconate phosphorylase plastin protein1 psme1 samhd1 serpin serpinb6 tymp wars
Tagcloud (Intersection) ?