FBXO7 and SEC24C

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FBXO7	SEC24C
Gene Name		F-box protein 7	SEC24 family member C
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Mitochondrion Cytosol Protein Complex	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat Perinuclear Region Of Cytoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein Kinase Binding	Molecular_function Protein Binding Zinc Ion Binding
	Biological Process	Mitochondrion Degradation Ubiquitin-dependent Protein Catabolic Process Protein Targeting To Mitochondrion Protein Ubiquitination Regulation Of Protein Stability Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Protein N-linked Glycosylation Via Asparagine Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process COPII Vesicle Coating Membrane Organization
Pathways			Diseases of glycosylation Metabolism of lipids and lipoproteins Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Regulation of cholesterol biosynthesis by SREBP (SREBF) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 MHC class II antigen presentation Class I MHC mediated antigen processing & presentation COPII (Coat Protein 2) Mediated Vesicle Transport ER to Golgi Transport Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Adaptive Immune System
Drugs
Diseases
GWAS		Red blood cell traits ( 23222517)
Protein-Protein Interactions		13 interactors: BIRC2 CDC34 ELF4 PARK2 PINK1 PSMA3 PSME3 PSMF1 RBBP6 SEC24C SKP1 UBE2D2 XPO1	7 interactors: APP FBXO7 MOS SEC23A SEC23B SPP1 WIPF1
Entrez ID		25793	9632
HPRD ID		07292	06217
Ensembl ID		ENSG00000100225	ENSG00000176986
Uniprot IDs		Q9Y3I1	E7EP00 P53992
PDB IDs			3EH2
Enriched GO Terms of Interacting Partners?		Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Positive Regulation Of Protein Ubiquitination Cellular Macromolecule Catabolic Process Protein Polyubiquitination Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Proteolysis Positive Regulation Of Ligase Activity Regulation Of Ubiquitin-protein Transferase Activity Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process G1/S Transition Of Mitotic Cell Cycle Cellular Protein Modification Process Regulation Of Proteolysis Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Protein Catabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Modification Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Protein Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Signaling Protein K48-linked Ubiquitination Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Apoptotic Process Regulation Of Protein Metabolic Process Negative Regulation Of Apoptotic Process Signal Transduction Involved In DNA Damage Checkpoint	Regulation Of Cell Cycle Phase Transition Establishment Of Localization In Cell Cellular Localization Regulation Of Cell Cycle Process Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Establishment Of Meiotic Spindle Orientation Negative Regulation Of Metaphase/anaphase Transition Of Meiotic Cell Cycle ER To Golgi Vesicle-mediated Transport Vesicle-mediated Transport Intracellular Transport Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Synaptic Growth At Neuromuscular Junction Cytoplasmic Transport Collateral Sprouting In Absence Of Injury Negative Regulation Of Cell Differentiation Regulation Of Protein Kinase Activity Negative Regulation Of Meiotic Cell Cycle Phase Transition Regulation Of Kinase Activity Negative Regulation Of Neuron Differentiation Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Establishment Of Meiotic Spindle Localization Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Protein Transport Regulation Of Cell Cycle Immune System Process Negative Regulation Of Collateral Sprouting Axon Choice Point Recognition Negative Regulation Of Axon Regeneration Golgi Vesicle Transport Reproduction Neuron Remodeling Regulation Of Protein Phosphorylation Regulation Of Developmental Growth Negative Regulation Of Neurogenesis Meiotic Spindle Organization Establishment Of Organelle Localization Negative Regulation Of Cell Development Positive Regulation Of Bone Resorption Extracellular Matrix Organization Extracellular Structure Organization Regulation Of Phosphorylation Defense Response Cellular Protein Localization Regulation Of Axon Regeneration Cellular Copper Ion Homeostasis Transport COPII Vesicle Coating Regulation Of Mitotic Cell Cycle
Tagcloud ?		atp13a2 autosomal called ceroid chilean dj elusive juvenile krs kufor levodopa lipofuscinoses named ncls neurodegeneration palsy park9 parkin parkinsonism pd pedigree pink1 pla2g6 pyramidal rakeb recessive supranuclear synuclein whereby	cargoes coated compensation considerably copii deficiency dispensable embryonic exhibiting fourth golgi haploinsufficient hepatocytes homozygous hypocholesterolemic lethality mammals nascent null paralog paralogs phenotypically tube vertebrate vesicles
Tagcloud (Difference) ?		atp13a2 autosomal called ceroid chilean dj elusive juvenile krs kufor levodopa lipofuscinoses named ncls neurodegeneration palsy park9 parkin parkinsonism pd pedigree pink1 pla2g6 pyramidal rakeb recessive supranuclear synuclein whereby	cargoes coated compensation considerably copii deficiency dispensable embryonic exhibiting fourth golgi haploinsufficient hepatocytes homozygous hypocholesterolemic lethality mammals nascent null paralog paralogs phenotypically tube vertebrate vesicles
Tagcloud (Intersection) ?