GABPA and ATF1

Number of citations of the paper that reports this interaction (PMID 10585419)
6

Data Source:
HPRD (in vitro)

		GABPA	ATF1
Gene Name		GA binding protein transcription factor, alpha subunit 60kDa	activating transcription factor 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm ATF1-ATF4 Transcription Factor Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Protein Complex Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Organelle Organization Mitochondrion Organization Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Positive Regulation Of Neuron Projection Development Response To Organic Cyclic Compound Response To Cobalt Ion Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Cellular Protein Complex Assembly Innate Immune Response Positive Regulation Of DNA Replication Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Stress-activated MAPK Cascade
Pathways		Organelle biogenesis and maintenance Transcriptional activation of mitochondrial biogenesis Mitochondrial biogenesis	CREB phosphorylation Toll Like Receptor 7/8 (TLR7/8) Cascade CREB phosphorylation Toll Like Receptor TLR6:TLR2 Cascade Activated TLR4 signalling Toll Like Receptor TLR1:TLR2 Cascade MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade MyD88 dependent cascade initiated on endosome TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88:Mal cascade initiated on plasma membrane Toll Like Receptor 9 (TLR9) Cascade Innate Immune System Signalling by NGF TRIF-mediated TLR3/TLR4 signaling MAP kinase activation in TLR cascade NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade Toll-Like Receptors Cascades Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade MAPK targets/ Nuclear events mediated by MAP kinases Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS			Colorectal cancer ( 20972440) Sudden cardiac arrest ( 21658281)
Protein-Protein Interactions		10 interactors: APP ATF1 CREBBP EP300 GABPB1 HCFC1 MED1 PINX1 SP1 SP3	20 interactors: BRCA1 CAMK1 CAMK2A CAMK2G CREB1 CREBBP CREM CSNK2A1 CSNK2A2 CSNK2B EDF1 GABPA GABPB1 HNF1B JUN PRKACA RPS6KA4 RPS6KA5 SPI1 SRA1
Entrez ID		2551	466
HPRD ID		11793	00440
Ensembl ID		ENSG00000154727	ENSG00000123268
Uniprot IDs		A8IE48 Q06546 Q8IYS3	P18846
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Metabolic Process Megakaryocyte Differentiation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Gene Expression Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Immune System Process Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Homeostatic Process Positive Regulation By Host Of Viral Transcription Embryonic Process Involved In Female Pregnancy Negative Regulation Of Transcription From RNA Polymerase II Promoter N-terminal Protein Amino Acid Acetylation Regulation Of Metabolic Process Erythrocyte Differentiation Histone Acetylation Erythrocyte Homeostasis Embryonic Placenta Development Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Myeloid Cell Homeostasis Monocyte Differentiation Notch Signaling Pathway	Cell Differentiation Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Developmental Process Multicellular Organismal Development Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Chromosome Organization Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Anatomical Structure Development Protein Phosphorylation Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Regulation Of Histone Acetylation Phosphorylation Response To Cytokine RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Axon Development Regulation Of Myeloid Cell Differentiation Gene Expression Chemotaxis Positive Regulation Of Histone Acetylation Negative Regulation Of Gene Expression Nervous System Development Cell Development Cellular Macromolecule Biosynthetic Process Axon Guidance Apoptotic Process Positive Regulation Of Peptidyl-lysine Acetylation Negative Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Positive Regulation Of Protein Acetylation Programmed Cell Death Anatomical Structure Morphogenesis
Tagcloud ?		annotation assigned bindings cistrome consensus enriched examines expresses foxa2 generates hepatic hre implying isoforms livers motifs principle ra rar rara raralpha rarb rarbeta redundant responsiveness sp1 stores tca uncovered	cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated
Tagcloud (Difference) ?		annotation assigned bindings cistrome consensus enriched examines expresses foxa2 generates hepatic hre implying isoforms livers motifs principle ra rar rara raralpha rarb rarbeta redundant responsiveness sp1 stores tca uncovered	cascades creb erk2 ester esters exclude fgf k1 k2 km mapk2 mapkap mc mirror msk1 ngf p90rsk pc12 phorbol phosphorylates pka polypeptide ro sapk2 sb ser133 sk suppresses unstimulated
Tagcloud (Intersection) ?