IFIT5 and IFIT3

Number of citations of the paper that reports this interaction (PMID 21642987)
66

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		IFIT5	IFIT3
Gene Name		interferon-induced protein with tetratricopeptide repeats 5	interferon-induced protein with tetratricopeptide repeats 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Actin Cytoskeleton Ruffle Membrane Apical Part Of Cell	Cytoplasm Mitochondrion Cytosol
	Molecular Function	TRNA Binding RNA Binding Single-stranded RNA Binding Poly(A) RNA Binding	Molecular_function Protein Binding Identical Protein Binding
	Biological Process	Innate Immune Response Defense Response To Virus	Negative Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Cellular Response To Interferon-alpha Negative Regulation Of Apoptotic Process Defense Response To Virus Type I Interferon Signaling Pathway
Pathways			Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: A2M APOE CDC37 ECSIT IFIT1 IFIT3 LONP1 MAST1 PRDX2 PSEN2 RAD23A RNF32 SARAF SRPK1 SRPK2	19 interactors: A2M APOE AQPEP CCDC67 CDC37 CYP2C8 ECSIT FANCA HAUS1 IFIT1 IFIT2 IFIT5 LONP1 MAST1 PSEN2 RAD23A RNF32 TMEM183A TPM3
Entrez ID		24138	3437
HPRD ID		17130	05228
Ensembl ID		ENSG00000152778	ENSG00000119917
Uniprot IDs		B4DDV1 Q13325	O14879 Q5T765
PDB IDs		3ZGQ 4HOQ 4HOR 4HOS 4HOT 4J0U
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Genome Replication Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Response To Stress Regulation Of Viral Process Negative Regulation Of Viral Genome Replication Cellular Response To Stimulus Negative Regulation Of Viral Process Immune Response Innate Immune Response Response To Stimulus Regulation Of Neuron Apoptotic Process Intracellular Signal Transduction Negative Regulation Of Protein Binding Regulation Of Neuron Death Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Nuclear Speck Organization Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Regulation Of MRNA Splicing, Via Spliceosome Defense Response Signal Transduction Immune System Process Positive Regulation Of Neuron Death Regulation Of Oxidoreductase Activity Regulation Of Cellular Process Regulation Of Apoptotic Process Protein Metabolic Process Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Regulation Of MRNA Processing Regulation Of Cell Death Signaling Regulation Of Catalytic Activity Negative Regulation Of Binding Negative Regulation Of Apoptotic Process Cell Communication Negative Regulation Of Programmed Cell Death Regulation Of RNA Splicing Response To Oxidative Stress Negative Regulation Of Helicase Activity Positive Regulation Of Phospholipid Efflux	Negative Regulation Of Protein Binding Response To Stress Negative Regulation Of Binding Positive Regulation Of Viral Genome Replication Regulation Of Protein Binding Defense Response To Virus Regulation Of Binding Oxidation-dependent Protein Catabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Positive Regulation Of Dendritic Spine Maintenance Negative Regulation Of Dendritic Spine Maintenance Negative Regulation Of Phospholipid Efflux Negative Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Lipid Transport Across Blood Brain Barrier Positive Regulation Of Postsynaptic Membrane Organization Negative Regulation Of Postsynaptic Membrane Organization Response To Virus Response To External Stimulus Regulation Of Viral Genome Replication Positive Regulation Of Viral Process Cellular Component Assembly Regulation Of Oxidoreductase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Presynaptic Membrane Organization Positive Regulation Of Presynaptic Membrane Organization Cellular Response To Stimulus Immune Response Innate Immune Response Negative Regulation Of Helicase Activity Positive Regulation Of Phospholipid Efflux Negative Regulation Of Cholesterol Biosynthetic Process Regulation Of Mitochondrial DNA Replication Regulation Of Postsynaptic Membrane Organization Very-low-density Lipoprotein Particle Clearance Response To Stimulus Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Microtubule Organizing Center Organization Multi-ciliated Epithelial Cell Differentiation Response To Type I Interferon Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Tau-protein Kinase Activity Response To Aluminum Ion Negative Regulation Of Cholesterol Efflux N-methyl-D-aspartate Receptor Clustering Intracellular Transport Of Viral Protein In Host Cell Regulation Of Presynaptic Membrane Organization Organelle Organization Negative Regulation Of Dendritic Spine Development
Tagcloud ?		alternatively bias breadth bridged cap0 cap1 defense discrimination ends excluding expand ifits introduce intron methylguanosine monophosphate mutagenesis n7 processed repeats rnas specificities substitutions tetratricopeptide thermostable transcriptase triphosphate trnas	adenovirus apobec3a ddx58 exact expand hiv ifi27 ifi44l ifit1 ifit2 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr
Tagcloud (Difference) ?		alternatively bias breadth bridged cap0 cap1 defense discrimination ends excluding ifits introduce intron methylguanosine monophosphate mutagenesis n7 processed repeats rnas specificities substitutions tetratricopeptide thermostable transcriptase triphosphate trnas	adenovirus apobec3a ddx58 exact hiv ifi27 ifi44l ifit1 ifit2 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr
Tagcloud (Intersection) ?		expand