ALK and ZC3HC1

Number of citations of the paper that reports this interaction (PMID 12748172)
11

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		ALK	ZC3HC1
Gene Name		anaplastic lymphoma receptor tyrosine kinase	zinc finger, C3HC-type containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Protein Complex Extracellular Vesicular Exosome	Nucleus Nuclear Membrane
	Molecular Function	NF-kappaB-inducing Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding Zinc Ion Binding Protein Kinase Binding
	Biological Process	Activation Of MAPK Activity Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Proliferation Phosphorylation Peptidyl-tyrosine Phosphorylation NIK/NF-kappaB Signaling Regulation Of Apoptotic Process Protein Autophosphorylation Neuron Development Positive Regulation Of NF-kappaB Transcription Factor Activity	Mitotic Nuclear Division Protein Ubiquitination Cell Division Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways
Drugs		Adenosine triphosphate
Diseases
GWAS			Coronary heart disease ( 21378990)
Protein-Protein Interactions		13 interactors: IKBKG IRS1 JAK3 MDK NPM1 PIK3R1 PLCG1 PTN PTPRZ1 SHC1 SHC3 TNFRSF8 ZC3HC1	9 interactors: ALK APP CUL1 MAPK1 MAPK3 PDPK1 TNFSF11 TSC22D1 UBC
Entrez ID		238	51530
HPRD ID		00104	11390
Ensembl ID		ENSG00000171094	ENSG00000091732
Uniprot IDs		B6D4Y2 Q9UM73	Q86WB0
PDB IDs		2KUP 2KUQ 2XB7 2XBA 2XP2 2YFX 2YHV 2YJR 2YJS 2YS5 2YT2 3AOX 3L9P 3LCS 3LCT 4ANL 4ANQ 4ANS 4DCE 4FNW 4FNX 4FNY 4FNZ 4FOB 4FOC 4FOD 4JOA
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Growth Hormone Receptor Signaling Pathway Signaling Cellular Response To Growth Hormone Stimulus Positive Regulation Of Cellular Biosynthetic Process Cell Communication Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cellular Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Insulin Receptor Signaling Pathway Response To Growth Hormone Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Innate Immune Response Cellular Response To Stimulus Defense Response Cellular Response To Fibroblast Growth Factor Stimulus Response To Peptide Hormone Response To Fibroblast Growth Factor Immune Response-regulating Signaling Pathway Regulation Of Immune Response Cellular Response To Organonitrogen Compound Regulation Of Apoptotic Process Response To Peptide Negative Regulation Of Apoptotic Process Cellular Response To Insulin Stimulus Regulation Of Cell Proliferation Negative Regulation Of Programmed Cell Death Cell Surface Receptor Signaling Pathway Response To Hormone Regulation Of Cell Death Negative Regulation Of Cell Death Cellular Response To Growth Factor Stimulus Cellular Response To Hormone Stimulus Learning Or Memory Positive Regulation Of Metabolic Process Response To Growth Factor Response To Organic Substance Cognition Response To Insulin	Positive Regulation Of Transferase Activity Activation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Activation Of MAPK Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Signal Transduction By Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Protein Phosphorylation Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Catalytic Activity Regulation Of Phosphorus Metabolic Process Response To Epidermal Growth Factor Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Apoptotic Process Programmed Cell Death Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Cell Death Phosphorylation Death Intracellular Signal Transduction Regulation Of Golgi Inheritance Neurotrophin TRK Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway MAPK Cascade Neurotrophin Signaling Pathway Toll-like Receptor 10 Signaling Pathway Fc-epsilon Receptor Signaling Pathway Caveolin-mediated Endocytosis
Tagcloud ?		2d accelerate alkaline chi2 depressed dihydroxyvitamin disuse forces fractures hydroxyvitamin hyperparathyroidism immobilization inclined oh osteopenia osteoporotic parathyroid pg phosphorus po4 pth regionally resorption sci serum skeleton subgroup subjects twelve
Tagcloud (Difference) ?		2d accelerate alkaline chi2 depressed dihydroxyvitamin disuse forces fractures hydroxyvitamin hyperparathyroidism immobilization inclined oh osteopenia osteoporotic parathyroid pg phosphorus po4 pth regionally resorption sci serum skeleton subgroup subjects twelve
Tagcloud (Intersection) ?