RABGAP1 and CARM1

Number of citations of the paper that reports this interaction (PMID 17124247)
4

Data Source:
BioGRID (genetic interference)
HPRD (in vivo)

		RABGAP1	CARM1
Gene Name		RAB GTPase activating protein 1	coactivator-associated arginine methyltransferase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Centrosome Cytosol Microtubule Associated Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding GTPase Activator Activity Rab GTPase Activator Activity Protein Binding Tubulin Binding Rab GTPase Binding	Transcription Coactivator Activity Protein Binding Beta-catenin Binding Protein Methyltransferase Activity Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity (H3-R17 Specific) Histone Methyltransferase Activity Protein Homodimerization Activity Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding
	Biological Process	Cell Cycle Positive Regulation Of Rab GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Cilium Assembly	Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Chromatin Organization Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Pathogenesis Viral Process Histone Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Protein Binding Regulation Of Intracellular Estrogen Receptor Signaling Pathway Histone H3-R2 Methylation Histone H3-R17 Methylation Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fat Cell Differentiation Response To CAMP Endochondral Bone Morphogenesis
Pathways			PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chromatin organization REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis RMTs methylate histone arginines Regulation of cholesterol biosynthesis by SREBP (SREBF) Chromatin modifying enzymes Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: CARM1 DISC1 GABARAPL1 MAP1LC3A RAB4A RAB6A RAB6B SENP1 SENP5	33 interactors: AXIN1 CREBBP CTNNB1 DAXX DNAJA3 ELAVL1 EP300 FLII FOS GRIP1 H3F3A H3F3B HIST1H3A MALT1 MEF2D MYOD1 MYOG NCOA1 NCOA2 NUDT21 PABPC1 PABPN1 PIAS1 PYGO1 QKI RABGAP1 RELA SMARCA4 SPAG8 SRC SRCAP TP53 UBE2I
Entrez ID		23637	10498
HPRD ID		06575	09158
Ensembl ID		ENSG00000011454	ENSG00000142453
Uniprot IDs		Q9Y3P9	Q86X55
PDB IDs			2Y1W 2Y1X 4IKP
Enriched GO Terms of Interacting Partners?		Rab Protein Signal Transduction Nucleophagy Protein Sumoylation Mitochondrion Degradation Ras Protein Signal Transduction Retrograde Vesicle-mediated Transport, Golgi To ER Cell Communication Organelle Disassembly Autophagic Vacuole Assembly Intra-Golgi Vesicle-mediated Transport Macroautophagy Cellular Response To Stimulus Peptidyl-amino Acid Modification Retrograde Transport, Endosome To Golgi Histone H3-R17 Methylation Vacuole Organization Histone H3-R2 Methylation Cellular Protein Localization Membrane Fusion Minus-end-directed Organelle Transport Along Microtubule Peptidyl-cysteine Methylation Cellular Response To Starvation Response To Stimulus Small GTPase Mediated Signal Transduction Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Protein Desumoylation Regulation Of Definitive Erythrocyte Differentiation Autophagy Protein Methylation Cellular Response To Nutrient Levels Response To Starvation Post-translational Protein Modification Endosomal Transport Cellular Response To Extracellular Stimulus Membrane Organization Intracellular Signal Transduction Protein Localization Early Endosome To Golgi Transport Peptidyl-lysine Modification Intracellular Protein Transport Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Golgi Vesicle Transport Antigen Processing And Presentation Signal Transduction Positive Regulation Of Proteolysis Peptidyl-arginine N-methylation Cellular Response To Nitrogen Starvation Mitochondrial Calcium Ion Homeostasis Intracellular Estrogen Receptor Signaling Pathway Signaling	Regulation Of Gene Expression Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Peptidyl-lysine Modification Chromatin Organization Transcription, DNA-templated Histone Acetylation RNA Biosynthetic Process Nitrogen Compound Metabolic Process Internal Peptidyl-lysine Acetylation Intracellular Receptor Signaling Pathway Peptidyl-lysine Acetylation Negative Regulation Of Cellular Metabolic Process Internal Protein Amino Acid Acetylation RNA Metabolic Process Protein Acetylation Intracellular Steroid Hormone Receptor Signaling Pathway Organelle Organization Androgen Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process DNA Methylation On Cytosine Negative Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Regulation Of Cellular Process Chromosome Organization Transcription From RNA Polymerase II Promoter Muscle Structure Development DNA Methylation
Tagcloud ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	additionally arginine biological blocked candidates cardiovascular cofactor compound cyanine docking effectively guide methyltransferase micromolar occupying optimization pentamethine permeated prmt1 prmt5 prmt8 probes provided roadmap selectivity serve systematically transduction trimethine
Tagcloud (Difference) ?		akap6 atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668	additionally arginine biological blocked candidates cardiovascular cofactor compound cyanine docking effectively guide methyltransferase micromolar occupying optimization pentamethine permeated prmt1 prmt5 prmt8 probes provided roadmap selectivity serve systematically transduction trimethine
Tagcloud (Intersection) ?