ORC3 and CCNE2

Number of citations of the paper that reports this interaction (PMID 15232106)
88

Data Source:
HPRD (in vitro)

		ORC3	CCNE2
Gene Name		origin recognition complex, subunit 3	cyclin E2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Origin Recognition Complex Nucleoplasm Nuclear Origin Of Replication Recognition Complex	Nucleoplasm Cytosol
	Molecular Function	DNA Replication Origin Binding Protein Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Neural Precursor Cell Proliferation	Cell Cycle Checkpoint Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication Initiation Cell Division
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex	DNA Damage/Telomere Stress Induced Senescence Cellular Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes p53-Dependent G1/S DNA damage checkpoint G0 and Early G1 S Phase Cyclin E associated events during G1/S transition Cell Cycle, Mitotic p53-Dependent G1 DNA Damage Response SCF(Skp2)-mediated degradation of p27/p21 G1/S Transition Cell Cycle Checkpoints Cyclin A:Cdk2-associated events at S phase entry SCF(Skp2)-mediated degradation of p27/p21 Mitotic G1-G1/S phases G1/S DNA Damage Checkpoints
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		18 interactors: APP CCNE2 CDC45 CDC6 CDK4 DBF4 HIST3H3 HIST4H4 MCM10 MCM4 MCM5 MCM7 ORC1 ORC2 ORC4 ORC5 ORC6 TERF2	11 interactors: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		23595	9134
HPRD ID		05398	04801
Ensembl ID		ENSG00000135336	ENSG00000175305
Uniprot IDs		Q9UBD5	O96020 Q8WUE3
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition DNA Replication DNA Replication Initiation Mitotic Cell Cycle DNA Metabolic Process DNA-dependent DNA Replication Mitotic Cell Cycle Process Cell Cycle Cell Cycle Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process DNA Strand Elongation Involved In DNA Replication Cellular Macromolecule Biosynthetic Process DNA Strand Elongation Macromolecule Biosynthetic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Phase Transition Cellular Metabolic Process DNA Duplex Unwinding Biosynthetic Process DNA Geometric Change Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle DNA Conformation Change Positive Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Telomere Maintenance DNA Replication Checkpoint DNA Unwinding Involved In DNA Replication Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Metabolic Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Organelle Organization Regulation Of Mitotic Cell Cycle Cell Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of DNA Replication Cell Cycle Checkpoint	G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Process Positive Regulation Of Proteolysis Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Protein Metabolic Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Protein Catabolic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cell Cycle Process Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Positive Regulation Of Cellular Protein Metabolic Process Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Positive Regulation Of Cell Cycle Arrest DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Mitotic Cell Cycle Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Regulation Of Protein Kinase Activity Regulation Of Cell Cycle Arrest Mitotic Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Cellular Protein Modification Process Regulation Of Kinase Activity Signal Transduction By P53 Class Mediator Positive Regulation Of Metabolic Process Regulation Of Protein Catabolic Process Mitotic Cell Cycle Arrest Negative Regulation Of Epithelial Cell Proliferation Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Serine/threonine Kinase Activity Cell Cycle Arrest Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Tagcloud ?			amplification amplifications aneuploidy breast carcinomas clinicopathologic coexist december ductal fish foci infiltrating january ki microarray multi myc often overlapping quantitative relationship roles selected showing situ sixty strong unique
Tagcloud (Difference) ?			amplification amplifications aneuploidy breast carcinomas clinicopathologic coexist december ductal fish foci infiltrating january ki microarray multi myc often overlapping quantitative relationship roles selected showing situ sixty strong unique
Tagcloud (Intersection) ?