QPRT and KRTAP10-3

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		QPRT	KRTAP10-3
Gene Name		quinolinate phosphoribosyltransferase	keratin associated protein 10-3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Vesicular Exosome	Keratin Filament
	Molecular Function	Nicotinate-nucleotide Diphosphorylase (carboxylating) Activity Protein Homodimerization Activity
	Biological Process	Vitamin Metabolic Process Water-soluble Vitamin Metabolic Process NAD Biosynthetic Process NAD Metabolic Process Quinolinate Catabolic Process Small Molecule Metabolic Process Protein Oligomerization
Pathways		Metabolism of vitamins and cofactors Defective GIF causes intrinsic factor deficiency Defective CD320 causes methylmalonic aciduria Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF Defective HLCS causes multiple carboxylase deficiency Defective MMAB causes methylmalonic aciduria type cblB Defective BTD causes biotidinase deficiency Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MTR causes methylmalonic aciduria and homocystinuria type cblG Defective MMAA causes methylmalonic aciduria type cblA Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective CUBN causes hereditary megaloblastic anemia 1 Defective AMN causes hereditary megaloblastic anemia 1 Defective MUT causes methylmalonic aciduria mut type Metabolism of water-soluble vitamins and cofactors Defects in biotin (Btn) metabolism Defective TCN2 causes hereditary megaloblastic anemia Nicotinate metabolism Defects in vitamin and cofactor metabolism Defects in cobalamin (B12) metabolism
Drugs		Niacin
Diseases
GWAS
Protein-Protein Interactions		7 interactors: GIT2 KRT40 KRTAP10-3 KRTAP10-8 KRTAP4-12 NOTCH2NL SUFU	288 interactors: ACY3 ADAMTSL3 ADAMTSL4 ADAMTSL5 AEN AES ALDH3B1 ALPI ALPP AP1M1 AQP1 AREG AVPI1 B4GALT7 BAHD1 BCL6B BMP7 BMS1P5 BUD31 BYSL C10orf62 C16orf59 C19orf57 C19orf66 C22orf39 C9orf9 CARD9 CARHSP1 CARKD CATIP CATSPER1 CBX2 CCDC26 CCER1 CD164 CD300A CD300LG CDK5R1 CERK CHIC2 CHRD CHRNG CLDN2 CLK3 CLK4 COL8A1 CREB5 CST2 CST9L CTNNBIP1 CTRC CXCL16 DAAM2 DDX43 DDX6 DERL2 DHRS1 DHX57 DMRT3 DNAL4 DOCK2 EFNA3 EGFL8 FAM124B FAM161A FAM27E3 FAM71E2 FAM74A4 FAM76B FARS2 FBXL18 FBXW5 FOXB1 FZD9 GABARAPL1 GATA2 GEM GFOD1 GIP GLIDR GLIPR2 GLP1R GLRX3 GNE GNMT GOLGA8EP GPRIN2 GSTP1 GTF3C5 HBG1 HBZ HHEX HIST3H2A HOXA1 HPCAL1 HSBP1 HSD3B7 HSPD1 HYAL2 IGSF8 IL2RG INPP5D IQUB IWS1 JOSD1 KAT5 KCNK1 KIAA0040 KIF9 KLHL38 KLK15 KLK8 KRT83 KRTAP10-1 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP13-1 KRTAP26-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-7 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE2A LCE3C LCE3E LIMS2 LINC00636 LINC01588 LMF2 LMNA LUZP4 LYVE1 MAPKBP1 MEOX2 MOBP MPP3 MRPL40 MXI1 NAA10 NAB2 NDUFAF3 NID2 NLK NOTCH2NL NPBWR2 NPDC1 NPPB NUBP2 NUDCD3 NUFIP2 OLFM2 OPCML OTX1 P2RY6 PCED1A PCSK5 PDE9A PDIA5 PGAP2 PGLS PIGS PIN1 PKD2 PLSCR1 POLL PPARD PRKAA2 PRKAB2 PRKAG1 PRPF31 PTGDS PTGER3 PTPMT1 PTPRH PVR PVRL2 PVRL3 QPRT R3HDM2 RAB7A RAMP3 RHNO1 RNF175 RPS19BP1 RPS28 RPUSD3 RTN4RL1 SCNM1 SDC3 SDCBP SELM SERF2 SLC15A3 SLC23A1 SLC25A10 SLC25A48 SLC35A2 SLC43A2 SLC6A20 SMCO4 SMCP SMOC1 SNAI1 SNHG11 SPATA3 SPATA8 SPG7 SPINK2 SPRY1 SPRY2 STK16 TBC1D23 TCEB3 THAP10 THAP7 TINAGL1 TMEM106C TMEM8A TNFRSF6B TNIP3 TNK2 TNP2 TNS2 TRIM42 TRPV6 TTC23 TXNDC5 TYMSOS TYRO3 UCP2 UNC45A UTP23 VPS11 WFDC10B WIF1 WT1 XCL1 YIPF3 ZBTB24 ZBTB9 ZFYVE21 ZFYVE26 ZMYND10 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF165 ZNF20 ZNF202 ZNF23 ZNF250 ZNF26 ZNF264 ZNF266 ZNF32 ZNF417 ZNF433 ZNF439 ZNF446 ZNF461 ZNF490 ZNF559 ZNF564 ZNF572 ZNF578 ZNF581 ZNF587 ZNF625 ZNF670 ZNF679 ZNF697 ZNF699 ZNF763 ZNF786 ZNF79 ZNF792 ZNRF2P1 ZSCAN21 ZSCAN26
Entrez ID		23475	386682
HPRD ID		06950	11189
Ensembl ID
Uniprot IDs		Q15274	P60369
PDB IDs		2JBM 3LAR 4KWV 4KWW
Enriched GO Terms of Interacting Partners?		Smoothened Signaling Pathway Involved In Spinal Cord Motor Neuron Cell Fate Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Interneuron Specification Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning Negative Regulation Of Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Negative Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Ventral Spinal Cord Interneuron Specification Spinal Cord Motor Neuron Cell Fate Specification Ventral Spinal Cord Interneuron Fate Commitment Ventral Spinal Cord Interneuron Differentiation Cytoplasmic Sequestering Of Transcription Factor Behavioral Response To Pain Cytoplasmic Sequestering Of Protein Negative Regulation Of Embryonic Development Spinal Cord Dorsal/ventral Patterning Neuron Fate Specification Negative Regulation Of Smoothened Signaling Pathway Spinal Cord Patterning Response To Pain Spinal Cord Motor Neuron Differentiation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription Factor Import Into Nucleus Ventral Spinal Cord Development Heart Looping Determination Of Heart Left/right Asymmetry Cell Differentiation In Spinal Cord Embryonic Heart Tube Morphogenesis Negative Regulation Of Protein Import Into Nucleus Regulation Of ARF GTPase Activity Negative Regulation Of Cellular Protein Catabolic Process Negative Regulation Of Ossification Neuron Fate Commitment Negative Regulation Of Protein Localization To Nucleus Embryonic Heart Tube Development Negative Regulation Of Intracellular Protein Transport Multicellular Organismal Response To Stress Regulation Of Transcription Factor Import Into Nucleus Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Cell Fate Specification Regulation Of Smoothened Signaling Pathway Regulation Of ARF Protein Signal Transduction Negative Regulation Of Protein Ubiquitination Neural Tube Closure Spinal Cord Development Determination Of Left/right Symmetry Determination Of Bilateral Symmetry Regulation Of Embryonic Development Negative Regulation Of Intracellular Transport Smoothened Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Protein Catabolic Process	Transcription, DNA-templated RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Cellular Process Cellular Process Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Immune Response To Tumor Cell Developmental Process Susceptibility To T Cell Mediated Cytotoxicity Negative Regulation Of MAP Kinase Activity Pattern Specification Process Transepithelial Transport Negative Regulation Of Cell Proliferation Fertilization Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Glomerular Mesangial Cell Proliferation Fusion Of Virus Membrane With Host Plasma Membrane Negative Regulation Of Glomerulus Development Positive Regulation Of Urine Volume Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Serine Phosphorylation Of STAT3 Protein Negative Regulation Of Signal Transduction Organ Development Multicellular Organismal Development Negative Regulation Of Transcription, DNA-templated Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of MAPK Cascade Metanephric Mesenchyme Development Negative Regulation Of Signaling Urogenital System Development Keratinization Regulation Of Cell Motility Negative Regulation Of Nucleic Acid-templated Transcription
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