FNTA and TGM2

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		FNTA	TGM2
Gene Name		farnesyltransferase, CAAX box, alpha	transglutaminase 2
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Associated Complex CAAX-protein Geranylgeranyltransferase Complex Protein Farnesyltransferase Complex	Mitochondrion Cytosol Plasma Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	Protein Farnesyltransferase Activity Protein Geranylgeranyltransferase Activity CAAX-protein Geranylgeranyltransferase Activity Rab Geranylgeranyltransferase Activity Protein Binding Microtubule Binding Acetylcholine Receptor Regulator Activity Receptor Tyrosine Kinase Binding Alpha-tubulin Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Metal Ion Binding
	Biological Process	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Transforming Growth Factor Beta Receptor Signaling Pathway Phototransduction, Visible Light Regulation Of Receptor Activity Rhodopsin Mediated Signaling Pathway Protein Farnesylation Protein Geranylgeranylation Regulation Of Rhodopsin Mediated Signaling Pathway Neurotransmitter Receptor Metabolic Process Positive Regulation Of Tubulin Deacetylation Positive Regulation Of Deacetylase Activity	Blood Vessel Remodeling Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Protein Homooligomerization Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation
Pathways		Inactivation, recovery and regulation of the phototransduction cascade Apoptotic cleavage of cellular proteins Visual phototransduction The phototransduction cascade Programmed Cell Death Apoptotic execution phase Diseases associated with visual transduction
Drugs			Guanosine-5\'-Diphosphate
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ACVR1 CENPF FNTB GBP1 HDAC6 HRAS INHBB KRAS PTP4A3 RHOB RPL13A SAFB2 STAT2 TGFB1 TGFBR1 TGM2 VAV2	55 interactors: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ATF4 BNIP3 C3 CASP3 COL4A3BP CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 HIST1H2BG HIST2H2BE HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LTBP1 MAP3K12 PAK1 PLCD1 PPHLN1 RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC SUMO1 TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		2339	7052
HPRD ID		00607	01825
Ensembl ID		ENSG00000168522	ENSG00000198959
Uniprot IDs		P49354	B4DIT7 F5H6P0 P21980
PDB IDs		1JCQ 1LD7 1LD8 1MZC 1S63 1SA4 1TN6 2F0Y 2H6F 2H6G 2H6H 2H6I 2IEJ 3E37	1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S
Enriched GO Terms of Interacting Partners?		Cellular Response To Organic Substance Response To Organic Substance Regulation Of Cell Death Response To Stress Regulation Of Signal Transduction Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Signaling Response To External Stimulus Defense Response Positive Regulation Of Programmed Cell Death Response To Growth Factor Pathway-restricted SMAD Protein Phosphorylation Wound Healing Positive Regulation Of Cell Death Regulation Of Apoptotic Process Response To Wounding Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Innate Immune Response Activin Receptor Signaling Pathway Locomotion Cell Migration Positive Regulation Of Signal Transduction Signal Transduction By Phosphorylation Positive Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Cellular Response To Growth Factor Stimulus Positive Regulation Of Apoptotic Process Regulation Of Cellular Protein Metabolic Process Movement Of Cell Or Subcellular Component Positive Regulation Of Rac Protein Signal Transduction Cellular Response To Stimulus Response To Abiotic Stimulus Regulation Of Protein Metabolic Process Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Response To Stimulus Cell Communication Blood Coagulation Tube Morphogenesis Hemostasis Branching Morphogenesis Of An Epithelial Tube Regulation Of Intracellular Signal Transduction Response To Radiation Negative Regulation Of Cell Cycle Activation Of MAPKK Activity Cell Development	Response To Stress Response To External Stimulus Response To Stimulus Secretion By Cell Establishment Of Localization In Cell Platelet Degranulation Secretion Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Localization Positive Regulation Of Metabolic Process Platelet Activation Regulation Of Cell Proliferation Response To Wounding Regulation Of Signal Transduction Response To Other Organism Positive Regulation Of Cellular Metabolic Process Wound Healing Response To Biotic Stimulus Immune System Process Response To Oxidative Stress Blood Coagulation Response To Organic Substance Hemostasis Regulation Of Cellular Process Regulation Of Signaling Regulation Of Cellular Component Organization Defense Response Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Cell Activation Regulation Of Catalytic Activity Signal Transduction Signaling Exocytosis Regulation Of Body Fluid Levels Positive Regulation Of Protein Metabolic Process Cell Communication Negative Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Positive Regulation Of Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Regulation Of Metabolic Process Viral Process Viral Entry Into Host Cell Entry Into Host Cell Regulation Of Protein Phosphorylation Response To Abiotic Stimulus
Tagcloud ?		21q11 8p11 aberration cbl comprehensively constitutional ct8m gained golga7 harbouring ikbkb jmml juvenile leukaemia leukaemogenesis malignancies mir486 monosomy mosaic mosaicisms myelomonocytic myst3 nf1 nras ptpn11 smallest submicroscopic trisomy ube2v2	antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately
Tagcloud (Difference) ?		21q11 8p11 aberration cbl comprehensively constitutional ct8m gained golga7 harbouring ikbkb jmml juvenile leukaemia leukaemogenesis malignancies mir486 monosomy mosaic mosaicisms myelomonocytic myst3 nf1 nras ptpn11 smallest submicroscopic trisomy ube2v2	antral atresia atretic bga build categorized cattle cct2 cyp11a1 cyp19a1 dab2 dairy dsg2 e2f1 follicle follicles follicular granulosa hybridized microarrays offers oocyte originating phases plateau segregation steroidogenesis transcriptomic ultimately
Tagcloud (Intersection) ?