TRIM2 and DTNBP1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		TRIM2	DTNBP1
Gene Name		tripartite motif containing 2	dystrobrevin binding protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Postsynaptic Density Sarcoplasm Cell Junction Axon Growth Cone Synaptic Vesicle Membrane BLOC-1 Complex Melanosome Membrane Sarcolemma Neuron Projection Dendritic Spine Postsynaptic Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Protein Binding
	Biological Process	Protein Ubiquitination Regulation Of Neuron Apoptotic Process	Positive Regulation Of Neurotransmitter Secretion Post-Golgi Vesicle-mediated Transport Blood Coagulation Anterograde Axon Cargo Transport Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Neuron Projection Development Actin Cytoskeleton Reorganization Melanosome Organization Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Membrane Organization
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system	Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Multiple sclerosis ( 21654844)
Protein-Protein Interactions		23 interactors: BCL2L11 CIB3 DTNBP1 GJB5 MNAT1 MYO5A OTUB2 SIRPA TNFAIP3 TNIK TRIM8 UBAC1 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2K UBE2U UBE2W	53 interactors: ABI3 AKAP6 ARFIP2 BLOC1S5 BLOC1S6 BRF1 BRK1 C19orf66 CCDC146 CCDC153 CCDC53 CCHCR1 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DST DTNA DTNB ELOVL7 EXOC4 EXOC7 GLTSCR1L HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 MACF1 NBEA NDN NUF2 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SNAPIN SRGAP3 SSC5D SYBU SYNE1 TRAF3IP1 TRIM2 TRIM27 TRIM32 TRIM9 TXLNB ZNF490
Entrez ID		23321	84062
HPRD ID		10279	06190
Ensembl ID		ENSG00000109654	ENSG00000047579
Uniprot IDs		Q9C040	D6RJC6 Q96EV8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein K11-linked Ubiquitination Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Response To Stress Cellular Macromolecule Catabolic Process Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Response To Stress Proteolysis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K63-linked Ubiquitination Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Protein Monoubiquitination Activation Of Innate Immune Response Catabolic Process ISG15-protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Innate Immune Response Protein K11-linked Deubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Innate Immune Response Cellular Response To DNA Damage Stimulus Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Protein K48-linked Deubiquitination Negative Regulation Of Protein Ubiquitination Protein K63-linked Deubiquitination Toll-like Receptor Signaling Pathway Regulation Of Cell Cycle Cellular Response To Oxygen Levels Cellular Response To Organic Substance Pigmentation Cellular Metabolic Process Response To Stimulus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Establishment Of Localization In Cell Movement Of Cell Or Subcellular Component Cellular Pigmentation Cellular Localization Endosomal Transport Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Organelle Organization Intracellular Transport Melanosome Transport Pigment Granule Transport Establishment Of Melanosome Localization Melanosome Localization Organelle Localization Microtubule-based Process Vesicle-mediated Transport Microtubule-based Movement Establishment Of Vesicle Localization Establishment Of Organelle Localization Pigmentation Vesicle Localization Protein Localization Protein Transport Anterograde Synaptic Vesicle Transport Establishment Of Protein Localization Melanosome Organization Pigment Granule Organization Anterograde Axon Cargo Transport Exocytosis Secretion By Cell Cell Projection Organization Synaptic Vesicle Transport Positive Regulation Of Cell Growth Endosome To Melanosome Transport Pigment Granule Maturation Axon Cargo Transport Small GTPase Mediated Signal Transduction Secretion Synaptic Vesicle Exocytosis Cellular Pigment Accumulation Nervous System Development Regulation Of Calcineurin-NFAT Signaling Cascade Cytoplasmic Transport Transport Positive Regulation Of Pigment Cell Differentiation Mitotic Nuclear Division Neuron Development Positive Regulation Of Developmental Pigmentation Negative Regulation Of Viral Release From Host Cell Generation Of Neurons
Tagcloud ?		acc adenoid aetiology bbc col9a3 constitutes driver drivers foxa1 gpm6b insidious lacks massive mel metastasise metastasises mia myoepithelial neuroblastomaand oestrogen recur ropn1 ropn1b segregated shares signatures silico sox10 visualisation	additive alleles cc convergent correction dysbindin glutamatergic heterozygotes homozygotes india irrespective morphometry neuregulin noted nrg1 pathophysiological polymorphism polymorphisms preliminary reductions rs1011313 rs35753505 schizophrenia tc trend uncorrected viz volumetric voxel
Tagcloud (Difference) ?		acc adenoid aetiology bbc col9a3 constitutes driver drivers foxa1 gpm6b insidious lacks massive mel metastasise metastasises mia myoepithelial neuroblastomaand oestrogen recur ropn1 ropn1b segregated shares signatures silico sox10 visualisation	additive alleles cc convergent correction dysbindin glutamatergic heterozygotes homozygotes india irrespective morphometry neuregulin noted nrg1 pathophysiological polymorphism polymorphisms preliminary reductions rs1011313 rs35753505 schizophrenia tc trend uncorrected viz volumetric voxel
Tagcloud (Intersection) ?