FLT3 and SH3BP2

Number of citations of the paper that reports this interaction (PMID 10409713)
3

Data Source:
HPRD (two hybrid)

		FLT3	SH3BP2
Gene Name		fms-related tyrosine kinase 3	SH3-domain binding protein 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Cytosol Integral Component Of Plasma Membrane External Side Of Plasma Membrane Protein Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Cytokine Receptor Activity Vascular Endothelial Growth Factor-activated Receptor Activity Protein Binding ATP Binding Protein Complex Binding Glucocorticoid Receptor Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding
	Biological Process	Leukocyte Homeostasis Myeloid Progenitor Cell Differentiation Pro-B Cell Differentiation Pro-T Cell Differentiation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Organonitrogen Compound Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Hemopoiesis B Cell Differentiation Organ Regeneration Common Myeloid Progenitor Cell Proliferation Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of B Cell Differentiation Lymphocyte Proliferation Protein Autophosphorylation Cellular Response To Cytokine Stimulus Cellular Response To Glucocorticoid Stimulus Dendritic Cell Differentiation	Signal Transduction Positive Regulation Of Signal Transduction
Pathways
Drugs		Sorafenib Sunitinib Ponatinib
Diseases
GWAS
Protein-Protein Interactions		14 interactors: CBL CBLB FIZ1 FLT3LG GRB2 IKBKG INPP5D NCK1 PTPN12 PTPN6 SH3BP2 SLA SOCS1 UBE2L6	21 interactors: ABL1 DBNL ERBB2 FGFR1 FLT3 FYN GRB2 LAT LCK PDLIM7 PLCG1 PLCG2 SH3KBP1 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70
Entrez ID		2322	6452
HPRD ID		00635	03657
Ensembl ID		ENSG00000122025	ENSG00000087266
Uniprot IDs		P36888	D6R919 P78314
PDB IDs		1RJB 3QS7 3QS9	2CR4 3TWR
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Signal Transduction Regulation Of Lymphocyte Activation Negative Regulation Of Signaling Regulation Of Cell Activation Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Positive Regulation Of Cell Activation Regulation Of Signaling Antigen Receptor-mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Innate Immune Response Immune Response-regulating Signaling Pathway Regulation Of Immune Response Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Immune Response Signaling Cell Communication Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Activation T Cell Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lymphocyte Activation Defense Response Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of T Cell Proliferation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Stimulus Dephosphorylation Regulation Of B Cell Differentiation	Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc-epsilon Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Blood Coagulation Innate Immune Response Wound Healing Hemostasis Platelet Activation Regulation Of Immune Response Enzyme Linked Receptor Protein Signaling Pathway Cell Activation Antigen Receptor-mediated Signaling Pathway Response To Wounding Positive Regulation Of Signal Transduction Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Body Fluid Levels Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of Immune Response Endocytosis Neurotrophin TRK Receptor Signaling Pathway Regulation Of Signaling Neurotrophin Signaling Pathway Immune Response Defense Response Immune System Process Regulation Of Lymphocyte Activation Phagocytosis Cell Migration Vesicle-mediated Transport Cell Motility Positive Regulation Of Immune System Process Regulation Of Cell Activation Locomotion Cell Surface Receptor Signaling Pathway Protein Autophosphorylation Regulation Of Intracellular Signal Transduction Leukocyte Migration Regulation Of Cell-cell Adhesion Cellular Response To Growth Factor Stimulus Response To Growth Factor Lymphocyte Activation
Tagcloud ?		action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated	bilateral boy calcineurin candidates cherubism copyright disfigurement facial giant granuloma immunohistological intra jaw jaws multinucleated nfatc1 operative opg osseous osteoclastogenesis osteoclasts osteogenesis protected radiological rankl reserved rights stabilization tacrolimus
Tagcloud (Difference) ?		action clonal clone contrasts differentiate divisions enforced evident flk2 interfered leukemic lif m1 macrophage morphologic overcame parental perturbed physiologic renewal renewing rescued responsiveness satisfies stimulating striking suppression unstimulated	bilateral boy calcineurin candidates cherubism copyright disfigurement facial giant granuloma immunohistological intra jaw jaws multinucleated nfatc1 operative opg osseous osteoclastogenesis osteoclasts osteogenesis protected radiological rankl reserved rights stabilization tacrolimus
Tagcloud (Intersection) ?