NFASC and SCN3B

Number of citations of the paper that reports this interaction (PMID 11470829)
35

Data Source:
HPRD (in vivo)

		NFASC	SCN3B
Gene Name		neurofascin	sodium channel, voltage gated, type III beta subunit
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Plasma Membrane Focal Adhesion Integral Component Of Membrane Paranodal Junction Node Of Ranvier Paranode Region Of Axon Axon Initial Segment Extracellular Vesicular Exosome	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Membrane Z Disc
	Molecular Function	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion	Voltage-gated Sodium Channel Activity Sodium Channel Regulator Activity Ion Channel Binding Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
	Biological Process	Protein Localization To Paranode Region Of Axon Axon Guidance Peripheral Nervous System Development Transmission Of Nerve Impulse Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Myelination Clustering Of Voltage-gated Sodium Channels Synapse Organization Protein Localization To Juxtaparanode Region Of Axon	Sodium Ion Transport Nervous System Development Positive Regulation Of Heart Rate Positive Regulation Of Sodium Ion Transport Sensory Perception Of Pain Sodium Ion Transmembrane Transport Membrane Depolarization Cardiac Muscle Contraction Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Protein Localization To Plasma Membrane Cardiac Muscle Cell Action Potential Involved In Contraction Ventricular Cardiac Muscle Cell Action Potential Membrane Depolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Interaction between L1 and Ankyrins Axon guidance Neurofascin interactions L1CAM interactions	Interaction between L1 and Ankyrins Axon guidance L1CAM interactions
Drugs
Diseases
GWAS		Dental caries ( 23064961)
Protein-Protein Interactions		10 interactors: ANK1 CNTNAP1 DCX NRCAM SCN1B SCN3B SCNN1B SDCBP SDCBP2 TNR	1 interactors: NFASC
Entrez ID		23114	55800
HPRD ID		12372	10497
Ensembl ID		ENSG00000163531	ENSG00000166257
Uniprot IDs		B4DRH7 O94856	Q9NY72
PDB IDs		3P3Y 3P40
Enriched GO Terms of Interacting Partners?		Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuronal Action Potential Propagation Neuron Projection Development Nervous System Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Locomotion Movement Of Cell Or Subcellular Component Generation Of Neurons Neurogenesis System Development Transmission Of Nerve Impulse Cell Development Response To External Stimulus Neurological System Process Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization Multicellular Organismal Development Anatomical Structure Development Membrane Depolarization During Cardiac Muscle Cell Action Potential Anatomical Structure Morphogenesis Developmental Process Cell-cell Signaling Involved In Cardiac Conduction Regulation Of Heart Rate By Cardiac Conduction Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Sodium Ion Transmembrane Transporter Activity Sodium Ion Transmembrane Transport Membrane Depolarization During Action Potential Regulation Of Membrane Depolarization Cardiac Muscle Cell Action Potential Cell Differentiation Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Sodium Ion Transport Monovalent Inorganic Cation Transport Central Nervous System Projection Neuron Axonogenesis Sodium Ion Transport Regulation Of Cardiac Muscle Cell Contraction Cardiac Conduction Cardiac Muscle Contraction Cell Migration Signaling	Clustering Of Voltage-gated Sodium Channels Neuronal Ion Channel Clustering Protein Localization To Paranode Region Of Axon Protein Localization To Juxtaparanode Region Of Axon Paranodal Junction Assembly Heterotypic Cell-cell Adhesion Neuron Maturation Myelin Assembly Transmission Of Nerve Impulse Peripheral Nervous System Development Cell-cell Junction Assembly Myelination Axon Ensheathment Cell Maturation Synapse Organization Cell Junction Assembly Cell-cell Junction Organization Axon Guidance
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