FOXO1 and TXNRD1

Number of citations of the paper that reports this interaction (PMID 11353774)
49

Data Source:
BioGRID (pull down)

		FOXO1	TXNRD1
Gene Name		forkhead box O1	thioredoxin reductase 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Transcription Factor Binding Transcription Factor Activity RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription Chromatin Binding Protein Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding	Thioredoxin-disulfide Reductase Activity Protein Binding Electron Carrier Activity Protein Disulfide Oxidoreductase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Blood Vessel Development Temperature Homeostasis Cellular Glucose Homeostasis Transcription From RNA Polymerase II Promoter Protein Acetylation Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Starvation Positive Regulation Of Autophagy Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Cold Cellular Response To Hyperoxia Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Maintenance Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Energy Homeostasis	Response To Reactive Oxygen Species Signal Transduction Nucleobase-containing Small Molecule Interconversion Cellular Lipid Metabolic Process Small Molecule Metabolic Process Cell Redox Homeostasis Nucleobase-containing Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT DAP12 signaling Downstream signaling events of B Cell Receptor (BCR) PI3K/AKT activation Regulation of beta-cell development PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF DAP12 interactions Signalling by NGF GAB1 signalosome AKT-mediated inactivation of FOXO1A Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR AKT phosphorylates targets in the nucleus Downstream signal transduction Fc epsilon receptor (FCERI) signaling Regulation of gene expression in beta cells Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System	PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Uptake and actions of bacterial toxins Metabolism of lipids and lipoproteins Detoxification of Reactive Oxygen Species Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Metabolism of nucleotides Synthesis and interconversion of nucleotide di- and triphosphates Uptake and function of diphtheria toxin
Drugs			Arsenic trioxide Nadph Dihydro-Nicotinamide-Adenine-Dinucleotidephosphate Flavin-Adenine Dinucleotide Spermidine Fotemustine
Diseases
GWAS		Central corneal thickness ( 20485516 20719862) Corneal structure ( 23291589)
Protein-Protein Interactions		31 interactors: AKT1 AR CEBPB CREBBP CSNK1G1 CTNNB1 DYRK1A EP300 ESR1 FHL2 FOXG1 G6PC GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 PAK1 PARP1 PPARG RARA SIRT1 SMAD3 SMAD4 SRC THRB TXNRD1 YWHAG YWHAZ	8 interactors: DMRTC2 FOXO1 GLRX2 POU2F1 POU2F2 PPP1R16A TXNDC17 TXNIP
Entrez ID		2308	7296
HPRD ID		00645	03068
Ensembl ID		ENSG00000150907	ENSG00000198431
Uniprot IDs		Q12778	B7Z1F4 B7Z2S5 B7Z904 E7EW10 Q16881
PDB IDs		3CO6 3CO7 3COA	1W1C 2CFY 2J3N 2ZZ0 2ZZB 2ZZC 3QFA 3QFB
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Response To Hormone Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Death Multicellular Organismal Development Cellular Response To Organic Substance Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Cellular Response To Hormone Stimulus Anatomical Structure Development Regulation Of RNA Metabolic Process Transcription, DNA-templated DNA-templated Transcription, Initiation Regulation Of Apoptotic Process RNA Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Cellular Metabolic Process System Development Response To Organic Substance Negative Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Developmental Process Organ Development Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Gene Expression Regulation Of Signaling Tissue Development Regulation Of Protein Localization Regulation Of Metabolic Process Reproductive Structure Development Epithelium Development Reproductive System Development Transcription From RNA Polymerase II Promoter Regulation Of Establishment Of Protein Localization Epithelial Cell Differentiation Cellular Nitrogen Compound Metabolic Process	Response To Reactive Oxygen Species Cell Differentiation Transcription, DNA-templated RNA Biosynthetic Process Response To Oxidative Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Inorganic Substance Regulation Of RNA Metabolic Process Cellular Response To Tumor Cell Positive Regulation Of Histone H3-K9 Dimethylation Positive Regulation Of Histone H3-K9 Trimethylation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Immunoglobulin Secretion Involved In Immune Response DNA Protection Response To Hydrogen Peroxide RNA Metabolic Process Developmental Process Nitrogen Compound Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Response To Temperature Stimulus Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Extracellular Stimulus Response To Tumor Cell Immunoglobulin Secretion Olfactory Placode Formation Cellular Response To Cold Spermatid Nucleus Elongation Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hyperoxia Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Lens Induction In Camera-type Eye Positive Regulation Of Histone H3-K9 Methylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of Energy Homeostasis Positive Regulation Of Cellular Metabolic Process Cellular Response To Nitric Oxide Response To Redox State Response To Nitric Oxide
Tagcloud ?		adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction subcellular transfections woundhealing wst	bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3
Tagcloud (Difference) ?		adipocytes aggressiveness bd box controversial cytoplasm du145 exclusion forkhead immunocytochemistry inactivation invasion leptin lncap longterm ly294002 matrigel nonobese obesity obr pc3 pca pi3k restriction subcellular transfections woundhealing wst	bring btg1 cyr61 dcs e7 epha1 hla idc idcs igfbp3 igsf6 il8 kpna7 mdc mdcs mrps11 ncr3 nfkb1a nfkbia padre pgf pidc pulsed pulsing rad21 sema6a srgn trem2 tubal3
Tagcloud (Intersection) ?