CAND2 and GLP1R

Number of citations of the paper that reports this interaction (PMID 23864651)
0

Data Source:
BioGRID (protein complementation assay, affinity chromatography technology)

		CAND2	GLP1R
Gene Name		cullin-associated and neddylation-dissociated 2 (putative)	glucagon-like peptide 1 receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding TBP-class Protein Binding	Transmembrane Signaling Receptor Activity Glucagon Receptor Activity
	Biological Process	Transcription, DNA-templated SCF Complex Assembly Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated	Energy Reserve Metabolic Process Response To Stress G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Learning Or Memory Regulation Of Heart Contraction CAMP-mediated Signaling Small Molecule Metabolic Process Regulation Of Insulin Secretion Cellular Response To Glucagon Stimulus
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Integration of energy metabolism G alpha (s) signalling events Regulation of insulin secretion Glucagon-type ligand receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs			Glucagon recombinant Exenatide Liraglutide
Diseases
GWAS
Protein-Protein Interactions		4 interactors: CNOT3 GLP1R TBP UBE3C	41 interactors: ACSF3 APH1A ARFRP1 ATP13A1 C14orf166 C18orf32 CALM1 CAND2 CEND1 CFI CYSTM1 ELOVL1 ERP29 GABBR2 GCG GPR37 GPRASP1 HPN IFITM3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 MFSD5 MRPL22 MYL6 NOTCH2NL NRGN NUCKS1 P4HTM PAQR6 PIGG SLC15A4 STMN1 STMN3 STOML2 SUMO1 SVOP SYNGR3 TMEM147 TSPAN13
Entrez ID		23066	2740
HPRD ID		19120	00677
Ensembl ID		ENSG00000144712	ENSG00000112164
Uniprot IDs		O75155	P43220
PDB IDs			3C59 3C5T 3IOL
Enriched GO Terms of Interacting Partners?		Gene Silencing	Microtubule Depolymerization Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Substantia Nigra Development Microtubule Polymerization Or Depolymerization Cerebellar Granular Layer Maturation Positive Regulation Of Cardiolipin Metabolic Process Protein Unfolding Positive Regulation Of Mitochondrial DNA Replication Stress-induced Mitochondrial Fusion Malonate Catabolic Process Molybdate Ion Transport
Tagcloud ?			2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Difference) ?			2a cardiac cardiomyopathies cardioprotective ccaat chaperone chemoattractant chop endoplasmic ex4 exendin fibrosis glucagon gluco grp78 homologous incretin infarction infiltration lipotoxicity mcp1 mhc monocyte reperfusion reticulum sarco serca2a viable
Tagcloud (Intersection) ?