GGA2 and BACE1

Number of citations of the paper that reports this interaction (PMID 12135764)
28

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		GGA2	BACE1
Gene Name		golgi-associated, gamma adaptin ear containing, ARF binding protein 2	beta-site APP-cleaving enzyme 1
Image
Gene Ontology Annotations	Cellular Component	Golgi Apparatus Trans-Golgi Network Endosome Membrane Clathrin Adaptor Complex Clathrin-coated Vesicle	Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Axon Cytoplasmic Vesicle Membrane
	Molecular Function	Protein Binding ADP-ribosylation Factor Binding	Beta-amyloid Binding Aspartic-type Endopeptidase Activity Protein Binding Beta-aspartyl-peptidase Activity Enzyme Binding
	Biological Process	Intracellular Protein Transport Vesicle-mediated Transport	Proteolysis Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process
Pathways
Drugs			MMI-175 N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide 4-(4-FLUOROBENZYL)PIPERIDINE N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE 6-[2-(3\'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE N~3~-BENZYLPYRIDINE-2,3-DIAMINE N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE 4-(2-aminoethyl)-2-cyclohexylphenol 4-(2-aminoethyl)-2-ethylphenol 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine (6R)-2-amino-6-[2-(3\'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide (6S)-2-amino-6-(3\'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
Diseases
GWAS			Cardiovascular disease risk factors ( 21779381)
Protein-Protein Interactions		30 interactors: AFTPH APP ARF1 ARF3 ATXN1 BACE1 BACE2 CA8 CCDC91 CLINT1 CLTC GGA1 GGA3 HGS HTT IGF2R LRP3 M6PR PIN1 RAB5A RABEP1 RABGEF1 RNF11 SORL1 SORT1 SPG21 STAB1 SYNRG TRIM23 VPS18	22 interactors: APP ATP1B1 BRI3 CMPK1 CSNK1D FBXO2 FURIN GGA1 GGA2 GGA3 ITM2C KHSRP LRP1 MMP2 NCSTN PCSK9 PDIA3 PLSCR1 PSAP PSEN1 RANBP9 SELPLG
Entrez ID		23062	23621
HPRD ID		09347	07255
Ensembl ID		ENSG00000103365	ENSG00000186318
Uniprot IDs		Q9UJY4	B7Z3K2 B7Z3Z4 P56817 Q5W9H2
PDB IDs		1MHQ	1FKN 1M4H 1PY1 1SGZ 1TQF 1UJJ 1UJK 1W50 1W51 1XN2 1XN3 1XS7 1YM2 1YM4 2B8L 2B8V 2F3E 2F3F 2FDP 2G94 2HIZ 2HM1 2IQG 2IRZ 2IS0 2NTR 2OAH 2OF0 2OHK 2OHL 2OHM 2OHN 2OHP 2OHQ 2OHR 2OHS 2OHT 2OHU 2P4J 2P83 2P8H 2PH6 2PH8 2Q11 2Q15 2QK5 2QMD 2QMF 2QMG 2QP8 2QU2 2QU3 2QZK 2QZL 2VA5 2VA6 2VA7 2VIE 2VIJ 2VIY 2VIZ 2VJ6 2VJ7 2VJ9 2VKM 2VNM 2VNN 2WEZ 2WF0 2WF1 2WF2 2WF3 2WF4 2WJO 2XFI 2XFJ 2XFK 2ZDZ 2ZE1 2ZHR 2ZHS 2ZHT 2ZHU 2ZHV 2ZJH 2ZJI 2ZJJ 2ZJK 2ZJL 2ZJM 2ZJN 3BRA 3BUF 3BUG 3BUH 3CIB 3CIC 3CID 3CKP 3CKR 3DM6 3DUY 3DV1 3DV5 3EXO 3FKT 3H0B 3HVG 3HW1 3I25 3IGB 3IN3 3IN4 3IND 3INE 3INF 3INH 3IVH 3IVI 3IXJ 3IXK 3K5C 3K5D 3K5F 3K5G 3KMX 3KMY 3KN0 3KYR 3L38 3L3A 3L58 3L59 3L5B 3L5C 3L5D 3L5E 3L5F 3LHG 3LNK 3LPI 3LPJ 3LPK 3MSJ 3MSK 3MSL 3N4L 3NSH 3OHF 3OHH 3OOZ 3PI5 3QBH 3QI1 3R1G 3R2F 3RSV 3RSX 3RTH 3RTM 3RTN 3RU1 3RVI 3S2O 3S7L 3S7M 3SKF 3SKG 3TPJ 3TPL 3TPP 3TPR 3U6A 3UDH 3UDJ 3UDK 3UDM 3UDN 3UDP 3UDQ 3UDR 3UDY 3UFL 3UQP 3UQR 3UQU 3UQW 3UQX 3VEU 3VF3 3VG1 3VV6 3VV7 3VV8 3WB4 3WB5 3ZMG 3ZOV 4ACU 4ACX 4AZY 4B00 4B05 4B0Q 4B1C 4B1D 4B1E 4B70 4B72 4B77 4B78 4BEK 4BFD 4D83 4D85 4D88 4D89 4D8C 4DH6 4DI2 4DJU 4DJV 4DJW 4DJX 4DJY 4DPF 4DPI 4DUS 4DV9 4DVF 4EWO 4EXG 4FCO 4FGX 4FM7 4FM8 4FRI 4FRJ 4FRK 4FRS 4FS4 4FSE 4FSL 4GID 4GMI 4H1E 4H3F 4H3G 4H3I 4H3J 4HA5 4HZT 4I0E 4I0F 4I0G 4I0H 4I0J 4I0Z 4I10 4I11 4I12 4I1C 4J0T 4J0V 4J0Y 4J0Z 4J17 4J1C 4J1E 4J1F 4J1H 4J1I 4J1K 4JOO 4JP9 4JPC 4JPE 4K8S 4K9H 4KE0 4KE1 4L7G 4L7H 4L7J 4LC7 4LXA 4LXK 4LXM
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Endocytosis Intracellular Transport Protein Transport Establishment Of Protein Localization Transport Establishment Of Localization In Cell Protein Localization Cellular Localization Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Lysosomal Transport Golgi Vesicle Transport Vacuolar Transport Cellular Protein Localization Endosomal Transport Regulation Of Vesicle-mediated Transport Endosome To Lysosome Transport Cytoplasmic Transport Visual Learning Membrane Organization Visual Behavior Protein Targeting To Lysosome Protein Localization To Lysosome Associative Learning Cellular Copper Ion Homeostasis Membrane Protein Ectodomain Proteolysis Signaling Protein Targeting To Vacuole Copper Ion Homeostasis Cell Communication Negative Regulation Of Signaling Establishment Of Protein Localization To Vacuole Learning Transition Metal Ion Homeostasis Membrane Protein Proteolysis Regulation Of Exocytosis Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Synaptic Plasticity Regulation Of Protein Catabolic Process Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Phosphorylation Neural Plate Formation Negative Regulation Of Kit Signaling Pathway Positive Regulation Of Early Endosome To Recycling Endosome Transport Negative Regulation Of Tau-protein Kinase Activity Negative Regulation Of Aspartic-type Endopeptidase Activity Involved In Amyloid Precursor Protein Catabolic Process Negative Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Choline O-acetyltransferase Activity	Neuron Differentiation Establishment Of Localization In Cell Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cell Death Regulation Of Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Extracellular Matrix Disassembly Protein Processing Transport Cellular Localization Intracellular Transport Generation Of Neurons Positive Regulation Of Proteolysis Notch Signaling Pathway Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Neurogenesis Regulation Of Signal Transduction Extracellular Matrix Organization Extracellular Structure Organization Protein Transport Vesicle-mediated Transport Amyloid Precursor Protein Catabolic Process Cell Activation Establishment Of Protein Localization Negative Regulation Of Neuron Differentiation Regulation Of Apoptotic Process Regulation Of Signaling Blood Coagulation Hemostasis Regulation Of Cell Death Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Locomotion Amyloid Precursor Protein Metabolic Process Nervous System Development Intracellular Protein Transport Negative Regulation Of Neurogenesis Response To External Stimulus Membrane Protein Ectodomain Proteolysis Beta-amyloid Metabolic Process Notch Receptor Processing Regulation Of Body Fluid Levels Regulation Of Receptor Activity Cholesterol Metabolic Process Neuron Development Negative Regulation Of Neuron Projection Development
Tagcloud ?		addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true	abca1 administrated amplitudes aspartic bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave
Tagcloud (Difference) ?		addressed adulthood allele attributable byg c57bl c57bl6 disrupted ear establishes gga1 gga3 ggas harbors homozygous hypomorphic insertional knockout lethality mutagenesis neonatal ola129sv placement redundancy ribosylation runted survive tigm true	abca1 administrated amplitudes aspartic bax erg excitotoxicity gcl injection inl inner intravitreal lxr lxralpha lxrbeta lxrs neuroprotective neurotoxicity nevertheless nmda orally preserved protects retinal speculate to90 to901317 upregulated wave
Tagcloud (Intersection) ?