ARHGEF15 and C11orf49

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		ARHGEF15	C11orf49
Gene Name		Rho guanine nucleotide exchange factor (GEF) 15	chromosome 11 open reading frame 49
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Dendrite	Nucleoplasm
	Molecular Function	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Positive Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Stress Fiber Assembly Retina Vasculature Morphogenesis In Camera-type Eye Negative Regulation Of Synapse Maturation
Pathways
Drugs
Diseases
GWAS			D-dimer levels ( 21502573)
Protein-Protein Interactions		8 interactors: C11orf49 CEP55 EPHA4 ESR1 ESRRG LASP1 MOB4 PIN1	12 interactors: ARHGEF15 CDC16 GSR PNMA5 PSMA1 RAB17 RAB29 RBM48 RPL8 RPS3A UBE3A UBQLN4
Entrez ID		22899	79096
HPRD ID		10535	08332
Ensembl ID		ENSG00000198844	ENSG00000149179
Uniprot IDs		O94989	B4DUV7 Q9H6J7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rho Guanyl-nucleotide Exchange Factor Activity Steroid Hormone Mediated Signaling Pathway Fasciculation Of Motor Neuron Axon Hormone-mediated Signaling Pathway Fasciculation Of Sensory Neuron Axon Prostate Epithelial Cord Elongation Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Negative Regulation Of Axon Regeneration Epithelial Cell Proliferation Involved In Mammary Gland Duct Elongation Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Branch Elongation Involved In Mammary Gland Duct Branching Antral Ovarian Follicle Growth DNA-templated Transcription, Initiation Regulation Of Branching Involved In Prostate Gland Morphogenesis Mammary Gland Branching Involved In Pregnancy Regulation Of Rho GTPase Activity Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Positive Regulation Of Cellular Metabolic Process Regulation Of Rho Protein Signal Transduction Corticospinal Tract Morphogenesis Vagina Development Positive Regulation Of Signal Transduction Regulation Of Axon Regeneration Uterus Development Regulation Of Signal Transduction Cellular Response To Organic Cyclic Compound Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Cell Separation After Cytokinesis Regulation Of Rap GTPase Activity Cellular Response To Estradiol Stimulus Prostate Gland Growth Regulation Of Rac GTPase Activity Branching Involved In Prostate Gland Morphogenesis Negative Regulation Of Intracellular Signal Transduction Cellular Response To Lipid Mammary Gland Epithelial Cell Proliferation Female Genitalia Development Axonal Fasciculation Regulation Of Rap Protein Signal Transduction Regulation Of Signaling Positive Regulation Of Monooxygenase Activity Branch Elongation Of An Epithelium	Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Polyubiquitination Viral Process Regulation Of Protein Ubiquitination Regulation Of Proteolysis Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Rab Protein Signal Transduction Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Cellular Pigmentation Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Negative Regulation Of Ubiquitin-protein Transferase Activity Sperm Entry Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Ligase Activity Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Synapse Organization Regulation Of Ubiquitin-protein Transferase Activity Catabolic Process Viral Transcription Regulation Of Synapse Structure Or Activity Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay SRP-dependent Cotranslational Protein Targeting To Membrane Negative Regulation Of Synapse Maturation Immunoglobulin Transcytosis In Epithelial Cells Mediated By Polymeric Immunoglobulin Receptor Cotranslational Protein Targeting To Membrane Protein Targeting To ER Negative Regulation Of Protein Ubiquitination Establishment Of Protein Localization To Endoplasmic Reticulum Pigmentation Ubiquitin-dependent Protein Catabolic Process Retrograde Transport, Plasma Membrane To Golgi Modification-dependent Protein Catabolic Process Protein Localization To Endoplasmic Reticulum Positive Regulation Of Protein Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Immunoglobulin Transcytosis In Epithelial Cells Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Translational Termination Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Protein Ubiquitination Nuclear-transcribed MRNA Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process MRNA Catabolic Process Protein Modification By Small Protein Conjugation Protein Catabolic Process
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