PPP6R1 and PRKDC

Number of citations of the paper that reports this interaction (PMID 20065038)
37

Data Source:
BioGRID (pull down)

		PPP6R1	PRKDC
Gene Name		protein phosphatase 6, regulatory subunit 1	protein kinase, DNA-activated, catalytic polypeptide
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm	Nucleoplasm Transcription Factor Complex Nucleolus Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex Membrane Nonhomologous End Joining Complex
	Molecular Function	Protein Binding Protein Phosphatase Binding	DNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity DNA-dependent Protein Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Enzyme Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Phosphoprotein Phosphatase Activity	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Somitogenesis Negative Regulation Of Protein Phosphorylation B Cell Lineage Commitment Pro-B Cell Differentiation T Cell Lineage Commitment DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cellular Protein Modification Process Brain Development Heart Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Gamma Radiation Peptidyl-serine Phosphorylation Protein Destabilization Positive Regulation Of Type I Interferon Production Cellular Response To Insulin Stimulus T Cell Differentiation In Thymus Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination Ectopic Germ Cell Programmed Cell Death Regulation Of Circadian Rhythm Positive Regulation Of Apoptotic Process Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Pathways			Nonhomologous End-joining (NHEJ) Cytosolic sensors of pathogen-associated DNA Processing of DNA ends prior to end rejoining STING mediated induction of host immune responses Double-Strand Break Repair IRF3-mediated induction of type I IFN Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: PRKDC SH3GL2	83 interactors: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CHEK1 CHEK2 CHUK CIB1 CTDP1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 ERG GSK3A GSK3B GZMB H2AFX HDAC3 HIST1H1A HIST1H1C HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11A NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R2 PPP6R3 PRKCD PTS RAD17 RBBP8 RNF144A RPA1 RPA2 SGOL1 SP1 SRF THRA THRB TP53 TREX1 UBC USF1 VPRBP WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ
Entrez ID		22870	5591
HPRD ID		17207	02941
Ensembl ID		ENSG00000105063	ENSG00000253729
Uniprot IDs		Q9UPN7	P78527
PDB IDs
Enriched GO Terms of Interacting Partners?		Pro-B Cell Differentiation Immunoglobulin V(D)J Recombination T Cell Receptor V(D)J Recombination B Cell Lineage Commitment Lymphoid Progenitor Cell Differentiation Ectopic Germ Cell Programmed Cell Death Central Nervous System Development Double-strand Break Repair Via Nonhomologous End Joining Protein Destabilization T Cell Lineage Commitment V(D)J Recombination Regulation Of Receptor Internalization Somatic Recombination Of Immunoglobulin Gene Segments Synaptic Vesicle Endocytosis Somatic Diversification Of Immunoglobulins Synaptic Vesicle Recycling Developmental Programmed Cell Death Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Response To Gamma Radiation Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Immunoglobulin Production T Cell Differentiation In Thymus Cell Development Mitotic G1 DNA Damage Checkpoint Mitotic G1/S Transition Checkpoint G1 DNA Damage Checkpoint Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Telomere Maintenance Positive Regulation Of Type I Interferon Production Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of ERBB Signaling Pathway Somitogenesis Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Signal Transduction In Response To DNA Damage Regulation Of Circadian Rhythm Mitotic DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Somite Development Immune System Process Mitotic DNA Integrity Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle B Cell Differentiation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II	Cellular Response To Stress DNA Repair Cellular Response To DNA Damage Stimulus DNA Recombination DNA Metabolic Process Double-strand Break Repair Response To Stress Immune System Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Response To Abiotic Stimulus Positive Regulation Of Metabolic Process Cellular Response To Stimulus Response To Organic Substance Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Immune System Development Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cell Cycle Cellular Response To Organic Substance Regulation Of Nitrogen Compound Metabolic Process Apoptotic Process Organelle Organization Cellular Metabolic Process Programmed Cell Death Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Process Cell Death Death Telomere Maintenance Developmental Process Immune Response Regulation Of Transcription From RNA Polymerase II Promoter Intrinsic Apoptotic Signaling Pathway DNA Damage Checkpoint Cellular Macromolecule Biosynthetic Process Response To Stimulus Mitotic Cell Cycle Macromolecule Biosynthetic Process Response To Radiation Organ Development Mitotic Cell Cycle Process
Tagcloud ?			1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?			1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic il2rg loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?