RASA3 and FES

Number of citations of the paper that reports this interaction (PMID 7691175)
5

Data Source:
HPRD (in vitro)

		RASA3	FES
Gene Name		RAS p21 protein activator 3	FES proto-oncogene, tyrosine kinase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Intrinsic Component Of The Cytoplasmic Side Of The Plasma Membrane	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Microtubule Cytoskeleton Cytoplasmic Membrane-bounded Vesicle Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cytoplasmic Vesicle
	Molecular Function	GTPase Activator Activity Ras GTPase Activator Activity Calcium-release Channel Activity Metal Ion Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Immunoglobulin Receptor Binding Phosphatidylinositol Binding
	Biological Process	Signal Transduction Positive Regulation Of Ras GTPase Activity Intracellular Signal Transduction Negative Regulation Of Ras Protein Signal Transduction Calcium Ion Transmembrane Transport	Protein Phosphorylation Chemotaxis Epidermal Growth Factor Receptor Signaling Pathway Multicellular Organismal Development Axon Guidance Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Microtubule Polymerization Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Mast Cell Degranulation Innate Immune Response Regulation Of Cell Differentiation Positive Regulation Of Myeloid Cell Differentiation Protein Autophosphorylation Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways			Signaling by SCF-KIT Axon guidance Semaphorin interactions Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling
Drugs
Diseases
GWAS			Blood pressure ( 21909110) Diastolic blood pressure ( 21909115) Hypertension ( 21909115) Systolic blood pressure ( 21909115)
Protein-Protein Interactions		5 interactors: APP FES GNB2L1 HCK RAP1A	31 interactors: BCAR1 BCR CSF2RB DOK1 DPYSL5 EGFR FKBP4 FKBP5 HSH2D HSPA4 IL4R IRS1 IRS2 JAK1 JAK2 JAK3 MDFI NEDD4 PDE4DIP PIK3R1 PLXNA1 POT1 PPID PTGES3 RASA1 RASA3 STAT3 TERF1 TRIM28 ZNF746 ZNF775
Entrez ID		22821	2242
HPRD ID		05537	01814
Ensembl ID		ENSG00000185989	ENSG00000182511
Uniprot IDs		F8W6X8 Q14644	P07332
PDB IDs			1WQU 2DCR 3BKB 3CBL 3CD3 4DYL 4E93
Enriched GO Terms of Interacting Partners?		Regulation Of Vesicle-mediated Transport Positive Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Component Biogenesis Peptidyl-tyrosine Autophosphorylation Regulation Of Actin Cytoskeleton Reorganization Regulation Of Protein Complex Assembly Cell Differentiation Regulation Of Protein Tyrosine Kinase Activity Regulation Of Phagocytosis Regulation Of Neuron Differentiation Respiratory Burst After Phagocytosis Regulation Of Cellular Component Organization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Neurogenesis Positive Regulation Of Protein Polymerization Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Peptidase Activity Anatomical Structure Development Leukocyte Migration Involved In Immune Response Synaptic Growth At Neuromuscular Junction Positive Regulation Of CAMP Catabolic Process Regulation Of Exocytosis Regulation Of Cell Development Regulation Of Cell Shape Enzyme Linked Receptor Protein Signaling Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Endocytosis Platelet Activation Developmental Process Positive Regulation Of Cytoskeleton Organization Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Hydrolase Activity Protein Autophosphorylation Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Neuron Projection Development Positive Regulation Of Cellular Protein Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Respiratory Burst Involved In Defense Response Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Translation Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Negative Regulation Of Oxidative Stress-induced Neuron Death	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Organonitrogen Compound Cellular Response To Peptide JAK-STAT Cascade Positive Regulation Of Transport Intracellular Signal Transduction Cellular Response To Hormone Stimulus Regulation Of Cellular Localization Regulation Of Cell Migration Signal Transduction Regulation Of Protein Transport Regulation Of Cell Motility Regulation Of Immune Response Response To Peptide Hormone Cellular Response To Stimulus Response To Organic Substance Regulation Of Establishment Of Protein Localization Regulation Of Locomotion Response To Peptide Regulation Of Cellular Component Movement Response To Stimulus Response To Hormone Positive Regulation Of Protein Transport Cellular Response To Organic Substance Signaling Regulation Of Cell Death Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Nucleocytoplasmic Transport Neurotrophin TRK Receptor Signaling Pathway Cell Communication Neurotrophin Signaling Pathway Regulation Of Protein Localization Response To Organonitrogen Compound Response To Stress Cytokine-mediated Signaling Pathway Chaperone-mediated Protein Folding Insulin Receptor Signaling Pathway Protein Import Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-amino Acid Modification ERBB Signaling Pathway Locomotion
Tagcloud ?			1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Difference) ?			1d4 counterpart e1c3 electrophoretic epsilon germline heavy hela iepsilon immunoglobulin initiating irs jak1 jak3 lysates mediating mobility parental promotor pronounced radiolabeled reconstitution restored shift stat6 tyrosine undergo utilized utilizing
Tagcloud (Intersection) ?