FHL1 and CBX4

Number of citations of the paper that reports this interaction (PMID 15710417)
4

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		FHL1	CBX4
Gene Name		four and a half LIM domains 1	chromobox homolog 4
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion	Nucleus Nucleoplasm Nuclear Speck PcG Protein Complex PRC1 Complex
	Molecular Function	Molecular_function Protein Binding Zinc Ion Binding Ion Channel Binding	Chromatin Binding Transcription Corepressor Activity Single-stranded RNA Binding Protein Binding Ligase Activity Enzyme Binding SUMO Binding Methylated Histone Binding Transcription Regulatory Region DNA Binding Phosphoprotein Binding
	Biological Process	Regulation Of Membrane Depolarization Muscle Organ Development Organ Morphogenesis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of Potassium Ion Transport Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Chromatin Modification Protein Sumoylation Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS
Protein-Protein Interactions		19 interactors: AKAP12 CBX4 DBN1 DEAF1 EED FHL2 HES1 HIVEP3 MYBPC1 PDE4DIP PRNP RBPJ RING1 SRF SRPK1 TTN TXNIP UBE2E2 USP15	18 interactors: CBS CSNK2B CTBP1 CTBP2 FHL1 HIST3H3 KMT2A LNX2 MBD1 MED9 RB1 RING1 RNF2 SATB1 SKIL SUV39H1 UBE2I ZEB2
Entrez ID		2273	8535
HPRD ID		02157	04357
Ensembl ID		ENSG00000022267	ENSG00000141582
Uniprot IDs		B7Z9A1 Q13642	O00257
PDB IDs		1X63 2CUP 2CUR 2EGQ	2K28 3I8Z
Enriched GO Terms of Interacting Partners?		Cardiocyte Differentiation Heart Morphogenesis Aorta Morphogenesis Negative Regulation Of Transcription, DNA-templated Heart Trabecula Morphogenesis Aorta Development Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Muscle Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process Striated Muscle Tissue Development Negative Regulation Of Gene Expression RNA Biosynthetic Process Muscle Cell Differentiation Cardiac Chamber Development Negative Regulation Of Biosynthetic Process Muscle Tissue Development Trabecula Morphogenesis RNA Metabolic Process Auditory Receptor Cell Fate Commitment Dorsal Aorta Morphogenesis Regulation Of Gene Expression Muscle Cell Development Artery Morphogenesis Dorsal Aorta Development Cell Differentiation Negative Regulation Of Cellular Metabolic Process Cardiac Muscle Tissue Development Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Regulation Of Transcription, DNA-templated Artery Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cardiac Muscle Cell Development Tissue Development Regulation Of Metabolic Process Cardiac Muscle Cell Myoblast Differentiation Nucleobase-containing Compound Metabolic Process Cell Development Heart Development Regulation Of Transcription From RNA Polymerase II Promoter Cardioblast Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Anatomical Structure Development Heart Trabecula Formation Cellular Nitrogen Compound Metabolic Process	Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Chromatin Modification Histone Modification RNA Metabolic Process Chromosome Organization Cellular Nitrogen Compound Metabolic Process Chromatin Organization Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Viral Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Histone H2A Monoubiquitination Anterior/posterior Pattern Specification Histone H2A Ubiquitination Cellular Metabolic Process Regulation Of Metabolic Process White Fat Cell Differentiation Developmental Process Histone Methylation Histone Monoubiquitination Negative Regulation Of Cell Proliferation Viral Genome Replication Organelle Organization Peptidyl-lysine Trimethylation Protein Methylation Histone Ubiquitination Cell Cycle Cell Differentiation Pattern Specification Process
Tagcloud ?		764g atrophy biopsy bodies boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness	3p accordingly bodies brachyury cbx7 chemicals ectodermal embryoid endodermal fgf5 foxa2 ideal markers meanwhile mebs mesodermal nanog nestin oct4 pcg perfluorooctane pfos pluripotency polycomb poses sma sox17 sox2 sulfonate
Tagcloud (Difference) ?		764g atrophy biopsy boy cardiomyopathy distal dreifuss dystrophy echocardiogram emery exon hemizygous hypertrophic linked missense muscle muscular myopathy occurring pathology postural predominantly reducing scapuloperoneal sequencing vacuolar wasting weakness	3p accordingly brachyury cbx7 chemicals ectodermal embryoid endodermal fgf5 foxa2 ideal markers meanwhile mebs mesodermal nanog nestin oct4 pcg perfluorooctane pfos pluripotency polycomb poses sma sox17 sox2 sulfonate
Tagcloud (Intersection) ?		bodies