FGF2 and SDC3

Number of citations of the paper that reports this interaction (PMID 16982797)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		FGF2	SDC3
Gene Name		fibroblast growth factor 2 (basic)	syndecan 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus	Golgi Lumen Plasma Membrane Membrane Integral Component Of Membrane Lysosomal Lumen
	Molecular Function	Fibroblast Growth Factor Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Heparin Binding Ligand-dependent Nuclear Receptor Transcription Coactivator Activity Chemoattractant Activity
	Biological Process	Activation Of MAPK Activity Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Phosphatidylinositol Biosynthetic Process Chemotaxis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Ras Protein Signal Transduction Nervous System Development Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Organ Morphogenesis Negative Regulation Of Fibroblast Migration Positive Regulation Of Phospholipase C Activity Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Extracellular Matrix Organization Hyaluronan Catabolic Process Inositol Phosphate Biosynthetic Process Somatic Stem Cell Maintenance Fc-epsilon Receptor Signaling Pathway Wound Healing Positive Regulation Of Cell Fate Specification Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Angiogenesis Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Embryonic Morphogenesis Positive Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cell Division Positive Regulation Of Cardiac Muscle Cell Proliferation Negative Regulation Of Cell Death Chondroblast Differentiation Negative Regulation Of Wound Healing Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Sprouting Angiogenesis Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor	Retinoid Metabolic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Glycosaminoglycan Catabolic Process Phototransduction, Visible Light Pathogenesis Extracellular Matrix Organization Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Small Molecule Metabolic Process
Pathways		Signaling by the B Cell Receptor (BCR) Phospholipase C-mediated cascade Signaling by FGFR in disease SHC-mediated cascade Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Signaling by FGFR2 mutants Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade Signaling by activated point mutants of FGFR1 Signaling by FGFR1 mutants PI3K Cascade Negative regulation of FGFR signaling Signaling by PDGF DAP12 interactions GAB1 signalosome Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer Activated point mutants of FGFR2 PI3K events in ERBB4 signaling Signaling by ERBB2 FGFR4 ligand binding and activation Syndecan interactions Signaling by EGFR Signaling by FGFR3 mutants Downstream signal transduction Signaling by activated point mutants of FGFR3 Fc epsilon receptor (FCERI) signaling Signaling by FGFR mutants Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade IRS-related events triggered by IGF1R Transcriptional regulation of pluripotent stem cells PI3K events in ERBB2 signaling FGFR1b ligand binding and activation Downstream signaling of activated FGFR FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR ligand binding and activation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Non-integrin membrane-ECM interactions FGFR3 ligand binding and activation Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR FGFR2 ligand binding and activation FRS2-mediated cascade IRS-mediated signalling FGFR1 ligand binding and activation Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PI3K Cascade	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIID - Sanfilippo syndrome D A tetrasaccharide linker sequence is required for GAG synthesis MPS IIIC - Sanfilippo syndrome C Retinoid metabolism and transport Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Non-integrin membrane-ECM interactions Diseases associated with visual transduction Defective EXT1 causes exostoses 1, TRPS2 and CHDS Syndecan interactions MPS IV - Morquio syndrome A Visual phototransduction MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates HS-GAG biosynthesis HS-GAG degradation MPS VI - Maroteaux-Lamy syndrome
Drugs		Sucralfate Pentosan Polysulfate Sirolimus 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
Diseases
GWAS
Protein-Protein Interactions		29 interactors: API5 CASP1 CD44 CEP57 CRYAB CSNK2A1 CSNK2A2 CSNK2B CXCL13 FGFBP1 FGFR1 FGFR3 FGFR4 FGFRL1 GPC3 GPC4 HSPG2 NRP1 PF4 PRMT1 PTX3 RPL6 RPS19 RPS6KA3 SDC1 SDC2 SDC3 THBS1 VTN	15 interactors: CASK COL5A1 CSK CTTN CUX1 EPHB4 FGF2 FYN KRTAP10-3 KRTAP5-9 MDK PTN TUBA1A TUBB TUBB2A
Entrez ID		2247	9672
HPRD ID		00622	01719
Ensembl ID		ENSG00000138685
Uniprot IDs		P09038	O75056
PDB IDs		1BAS 1BFB 1BFC 1BFF 1BFG 1BLA 1BLD 1CVS 1EV2 1FGA 1FQ9 1II4 1IIL 2BFH 2FGF 4FGF
Enriched GO Terms of Interacting Partners?		Response To External Stimulus Glycosaminoglycan Catabolic Process Anatomical Structure Morphogenesis Anatomical Structure Development Response To Stimulus Cellular Response To Stimulus Signal Transduction Chondroitin Sulfate Metabolic Process Regulation Of Proteolysis Negative Regulation Of Proteolysis Developmental Process Negative Regulation Of Protein Processing Signaling Phototransduction, Visible Light Retinoid Metabolic Process Cell Communication Locomotion Cellular Response To Growth Factor Stimulus Regulation Of Protein Processing Positive Regulation Of Signal Transduction Diterpenoid Metabolic Process Response To Growth Factor Detection Of Visible Light Regulation Of Cellular Component Organization Chemotaxis System Development Glycosaminoglycan Metabolic Process Multicellular Organismal Development Phototransduction Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Glycosaminoglycan Biosynthetic Process Regulation Of Cellular Process Proteoglycan Metabolic Process Detection Of Light Stimulus Response To Organic Substance Cell Differentiation Pathogenesis Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Isoprenoid Metabolic Process Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Hydrolase Activity Defense Response Regulation Of Peptidase Activity Protein Metabolic Process Negative Regulation Of Peptidase Activity Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity	Cell Migration Cell Motility Protein Polymerization Movement Of Cell Or Subcellular Component Nervous System Development Locomotion Anatomical Structure Development Organ Development System Development Developmental Process Response To Wounding Cellular Protein Complex Assembly Multicellular Organismal Development Positive Regulation Of Cell Division Cell Migration Involved In Sprouting Angiogenesis Enzyme Linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Blood Vessel Endothelial Cell Migration Neurogenesis Protein Autophosphorylation Cell Differentiation Peptidyl-tyrosine Autophosphorylation Tissue Development Epithelium Development Neuron Differentiation Wound Healing Chemotaxis Cellular Macromolecular Complex Assembly Neuron Projection Morphogenesis Cell Adhesion Regulation Of Cell Division Learning Or Memory Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Peptidyl-tyrosine Phosphorylation Sprouting Angiogenesis 'de Novo' Posttranslational Protein Folding Cognition 'de Novo' Protein Folding Defecation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Integrin Biosynthetic Process Cellular Response To Peptide Hormone Stimulus Defense Response Negative Regulation Of Wound Healing Cellular Response To Peptide T Cell Costimulation Innate Immune Response Neuron Projection Development Endothelial Cell Migration
Tagcloud ?		accumulated altering bdnf believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Difference) ?		accumulated altering bdnf believed ca2 causally cerebellar correlates dependency downregulating downregulation elicited evoked excitotoxic excitotoxicity fibroblast fura granule neurotrophic nmda nr1 nr2a nr2c prevent protect rnase trauma trophic vulnerable	artemin artn benign carcinoma diverse gfralpha1 gfralpha3 herein invasiveness largely malignancies mammary mediating metastases namely node oncogenicity outcome positively positivity predictors promoting relapse restricted significance syndecan synergistic univariate upstream
Tagcloud (Intersection) ?