SPATS1 and SPG7

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SPATS1	SPG7
Gene Name		spermatogenesis associated, serine-rich 1	spastic paraplegia 7 (pure and complicated autosomal recessive)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Mitochondrion Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function		Metalloendopeptidase Activity Protein Binding ATP Binding Peptidase Activity Zinc Ion Binding Unfolded Protein Binding
	Biological Process		Proteolysis Mitochondrion Organization Nervous System Development Anterograde Axon Cargo Transport
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: CFLAR GPHN SPG7	23 interactors: CCNDBP1 HNRNPK KHDRBS2 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP4-12 LRIF1 LZTS2 MAPK6 MDFI MTUS2 NOTCH2NL PLSCR1 PNMA1 PSME3 PSTPIP1 RALY RBPMS SPATS1 STAMBP TRIM28
Entrez ID		221409	6687
HPRD ID		10248	04149
Ensembl ID		ENSG00000249481	ENSG00000197912
Uniprot IDs		Q496A3	Q9UQ90
PDB IDs			2QZ4
Enriched GO Terms of Interacting Partners?		Glycine Receptor Clustering Molybdenum Incorporation Into Molybdenum-molybdopterin Complex Establishment Of Synaptic Specificity At Neuromuscular Junction Negative Regulation Of Myoblast Fusion Skeletal Muscle Atrophy Striated Muscle Atrophy Muscle Atrophy Regulation Of Satellite Cell Proliferation Skeletal Myofibril Assembly Skeletal Muscle Adaptation Negative Regulation Of Syncytium Formation By Plasma Membrane Fusion Molybdopterin Cofactor Biosynthetic Process Molybdopterin Cofactor Metabolic Process Mo-molybdopterin Cofactor Biosynthetic Process Negative Regulation Of Myotube Differentiation Regulation Of Necroptotic Process Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Myoblast Fusion Regulation Of Necrotic Cell Death Skeletal Muscle Tissue Regeneration Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Anterograde Axon Cargo Transport Postsynaptic Membrane Organization System Development Negative Regulation Of Muscle Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Axon Cargo Transport Receptor Clustering Tissue Regeneration Neuromuscular Junction Development Regulation Of Myotube Differentiation Multicellular Organismal Development Anatomical Structure Development Myofibril Assembly Synapse Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Water-soluble Vitamin Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Proteolysis Regulation Of Striated Muscle Cell Differentiation Developmental Process Protein Metabolic Process Zymogen Activation	Regulation Of Protein Localization To Nucleus Regulation Of Protein Import Into Nucleus Negative Regulation Of Wnt Signaling Pathway Regulation Of Cellular Process Regulation Of Nucleocytoplasmic Transport Regulation Of Intracellular Protein Transport Gene Expression Regulation Of Wnt Signaling Pathway Negative Regulation Of Viral Process Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of DNA Demethylation Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Regulation Of Protein Localization Regulation Of Transcription Factor Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Cytokinesis Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Embryonic Placenta Development Transcription, DNA-templated Inflammatory Response Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Regulation Of Intracellular Transport RNA Metabolic Process RNA Biosynthetic Process Convergent Extension Involved In Axis Elongation Regulation Of Genetic Imprinting Phosphatidylserine Biosynthetic Process DNA Methylation Involved In Embryo Development Regulation Of Cellular Localization Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Viral Process Response To Stimulus Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Positive Regulation Of Intracellular Protein Transport RNA Processing Negative Regulation Of Signaling Regulation Of Signal Transduction Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor Biosynthetic Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Spindle Midzone Assembly Placenta Development Positive Regulation Of Protein Metabolic Process Phospholipid Scrambling Regulation Of Protein Transport
Tagcloud ?			ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness
Tagcloud (Difference) ?			ablated accumulates axons biogenesis corticospinal defines exposes hereditary implication isoform knock lacks limbs lumen microsomal name owing paraplegia paraplegin performs proteases recessive resides retina retrograde spastic spasticity usage weakness
Tagcloud (Intersection) ?