FCGR2A and CRYAB

Number of citations of the paper that reports this interaction (PMID 21357544)
7

Data Source:
BioGRID (pull down, affinity chromatography technology)

		FCGR2A	CRYAB
Gene Name		Fc fragment of IgG, low affinity IIa, receptor (CD32)	crystallin, alpha B
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrion Golgi Apparatus Cytosol Plasma Membrane Cell Surface Microtubule Cytoskeleton Z Disc Actin Filament Bundle Extracellular Vesicular Exosome
	Molecular Function	IgG Binding	Structural Constituent Of Eye Lens Protein Binding Microtubule Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Innate Immune Response	Response To Hypoxia Lens Development In Camera-type Eye Protein Folding Muscle Contraction Tubulin Complex Assembly Muscle Organ Development Aging Regulation Of Cell Death Negative Regulation Of Cell Growth Microtubule Polymerization Or Depolymerization Response To Estradiol Negative Regulation Of Intracellular Transport Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Protein Homooligomerization Stress-activated MAPK Cascade Apoptotic Process Involved In Morphogenesis Cellular Response To Gamma Radiation Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Regulation of actin dynamics for phagocytic cup formation Innate Immune System
Drugs
Diseases
GWAS		Helicobacter pylori serologic status ( 23652523) Inflammatory bowel disease ( 23128233) Kawasaki disease ( 22081228) Lipid metabolism phenotypes ( 22286219) Ulcerative colitis ( 19915573 20228799 21297633)
Protein-Protein Interactions		13 interactors: BLK CRP CRYAB FYN GP6 HCK LAT LGALS3 LYN PIK3R1 SHC1 SYK UBQLN1	44 interactors: ACOT7 APOC2 APP AVP B2M BAG3 BCL2L1 BMPR2 CASP3 CCL22 CCND1 CRYAA CRYBA1 CRYBB2 CRYGC CRYGD CS DDX20 DES EPB41 FCGR2A FGF2 GFAP HBA1 HSPB1 HSPB2 HSPB8 INS KRTAP19-5 KRTAP8-1 LALBA MDH2 MIP MRPL11 NGF PRKAG3 PSMA3 SNCA SOD1 TNPO2 TRAPPC6A TTN UBE2D1 VEGFA
Entrez ID		2212	1410
HPRD ID		00906	00428
Ensembl ID		ENSG00000143226	ENSG00000109846
Uniprot IDs		P12318	P02511
PDB IDs		1FCG 1H9V 3D5O 3RY4 3RY5 3RY6	2KLR 2WJ7 2Y1Y 2Y1Z 2Y22 2YGD 3L1G 3SGM 3SGN 3SGO 3SGP 3SGR 3SGS
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Regulation Of Immune Response Platelet Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Stress Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Positive Regulation Of Immune System Process Wound Healing Immune System Process Positive Regulation Of Immune Response Cell Activation Response To Wounding Blood Coagulation Hemostasis Fc-epsilon Receptor Signaling Pathway Cell Migration Phagocytosis Peptidyl-tyrosine Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Cell Motility Regulation Of T Cell Activation Cellular Response To Peptide Hormone Stimulus Regulation Of Body Fluid Levels Cellular Response To Peptide Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Protein Autophosphorylation Locomotion Response To Peptide Hormone Cellular Response To Stimulus Cellular Response To Organonitrogen Compound Regulation Of Cell Activation Leukocyte Activation Response To Peptide Response To Hormone Movement Of Cell Or Subcellular Component Transcription Factor Import Into Nucleus Cellular Response To Hormone Stimulus	Response To Stress Negative Regulation Of Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Cell Death Response To External Stimulus Negative Regulation Of Apoptotic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Response To Abiotic Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Endothelial Cell Chemotaxis Positive Regulation Of Transferase Activity Regulation Of Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Regulation Of Apoptotic Process Negative Regulation Of Catalytic Activity Regulation Of Lipid Metabolic Process Response To Stimulus Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Cellular Response To Oxidative Stress Regulation Of Proteolysis Regulation Of Protein Metabolic Process Positive Regulation Of Cell Growth Positive Regulation Of Growth Response To Wounding Neuron Apoptotic Process Camera-type Eye Development Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Protein Phosphorylation Regulation Of Neuron Apoptotic Process Regulation Of Lipid Biosynthetic Process Organ Development Neuron Death Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Eye Development Programmed Cell Death Sensory Organ Development Response To Oxidative Stress Platelet Degranulation Sensory Perception
Tagcloud ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Difference) ?		arm arms benefit carriers concurrently deriving dfs equivocal fcgammar genotypes genotypic genotyping i232t igg1 killer log n9831 polymorphisms pooled portion proportional r131h rank sequentially superior trastuzumab v158f	adaptive aggregated antiapoptotic assisting cardiomyocyte cardiomyocytes chaperons confers correct crystallin elicit emphasizing folding hsp hsps interplay lumen mini misfolded mitigate myocardium myocytes referred stressed stresses undergo unfolded upr worldwide
Tagcloud (Intersection) ?