PTK2B and SORBS2

Number of citations of the paper that reports this interaction (PMID 15128873)
19

Data Source:
HPRD (in vitro)

		PTK2B	SORBS2
Gene Name		protein tyrosine kinase 2 beta	sorbin and SH3 domain containing 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Focal Adhesion Cell Cortex Postsynaptic Density N-methyl-D-aspartate Selective Glutamate Receptor Complex Lamellipodium Axon Dendrite Growth Cone Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuronal Cell Body Cell Body Membrane Raft Perinuclear Region Of Cytoplasm Apical Dendrite	Nucleus Plasma Membrane Actin Cytoskeleton Z Disc Perinuclear Region Of Cytoplasm
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Transducer Activity N-methyl-D-aspartate Selective Glutamate Receptor Activity Receptor Binding Protein Binding ATP Binding Protein Complex Binding 3-phosphoinositide-dependent Protein Kinase Binding	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Structural Constituent Of Muscle Protein Domain Specific Binding Poly(A) RNA Binding Metal Ion Binding
	Biological Process	MAPK Cascade Angiogenesis Oocyte Maturation Response To Hypoxia Positive Regulation Of Cell-matrix Adhesion Sprouting Angiogenesis Marginal Zone B Cell Differentiation Protein Complex Assembly Protein Phosphorylation Apoptotic Process Response To Stress Cellular Defense Response Response To Osmotic Stress Signal Transduction Cell Surface Receptor Signaling Pathway Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Response To Mechanical Stimulus Response To Hormone Response To Glucose Response To Lithium Ion Positive Regulation Of Endothelial Cell Migration Negative Regulation Of Muscle Cell Apoptotic Process Regulation Of CGMP-mediated Signaling Regulation Of Macrophage Chemotaxis Positive Regulation Of Neuron Projection Development Glial Cell Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Regulation Of CGMP Biosynthetic Process Positive Regulation Of Actin Filament Polymerization Neuron Projection Development Activation Of Rac GTPase Activity Regulation Of Inositol Trisphosphate Biosynthetic Process Tumor Necrosis Factor-mediated Signaling Pathway Ionotropic Glutamate Receptor Signaling Pathway Response To Immobilization Stress Peptidyl-tyrosine Autophosphorylation Response To Cocaine Response To Drug Response To Hydrogen Peroxide Activation Of Janus Kinase Activity Negative Regulation Of Apoptotic Process Stress Fiber Assembly Negative Regulation Of Potassium Ion Transport Positive Regulation Of JUN Kinase Activity Negative Regulation Of Neuron Apoptotic Process Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Regulation Of Nitric Oxide Biosynthetic Process Bone Resorption Response To Ethanol Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Calcium-mediated Signaling Positive Regulation Of Nitric-oxide Synthase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To CAMP Response To Calcium Ion Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Establishment Of Cell Polarity Regulation Of Actin Cytoskeleton Reorganization Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of B Cell Chemotaxis	Actin Filament Organization Cell Adhesion Biological_process Cell Migration
Pathways		Signaling by Interleukins Signaling by VEGF Cytokine Signaling in Immune system Interleukin-2 signaling Signal regulatory protein (SIRP) family interactions VEGFA-VEGFR2 Pathway
Drugs		Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Diseases
GWAS		Dental caries ( 23259602)	Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		70 interactors: ARHGAP21 ARHGAP5 ASAP1 ASAP2 BCAR1 CBL CCR5 CRK DCC DLG3 DLG4 DLGAP3 EFS EGFR ERBB2 ERBB3 EWSR1 FGFR2 FGFR3 FLT1 FYN GNA13 GRB2 GRIN2A GSN IL7R ITGB2 ITGB3 JAK1 JAK2 JAK3 KCNA2 LCK LPXN LYN MAP3K4 MAPT MATK MCAM MYH2 NEDD9 NPHP1 PDCD6IP PDPK1 PIK3R1 PITPNM1 PITPNM2 PITPNM3 PRKCD PTK2 PTPN11 PTPN12 PTPN6 PXN RASA1 RB1CC1 SH2D3C SHC1 SKAP2 SLC2A1 SNCA SORBS2 SRC STAP1 STAT3 SYK TGFB1I1 TLN1 VAV1 ZAP70	35 interactors: ABL1 ABL2 ACTN1 ADAM15 AKT1 AKT2 ATPAF2 CBL DLGAP1 DLGAP2 DLGAP4 EFS EGFR FLOT1 MDM2 MLLT4 NCK2 NR1H2 PAK1 PAK2 PALLD PKM PTK2B PTPN12 RPL9 SEMA6A SH2D4A SYNJ1 TRAF4 VCL VPS37C WAS WASF1 YWHAE YWHAZ
Entrez ID		2185	8470
HPRD ID		03131	12473
Ensembl ID		ENSG00000120899	ENSG00000154556
Uniprot IDs		Q14289	B7Z3D7 B7Z997 O94875
PDB IDs		2FO6 2LK4 3CC6 3ET7 3FZO 3FZP 3FZR 3FZS 3FZT 3GM1 3GM2 3GM3 3H3C 3U3C 3U3F 4EKU 4H1J 4H1M	4IGZ
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Signaling Movement Of Cell Or Subcellular Component Epidermal Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation ERBB Signaling Pathway Response To Wounding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Locomotion Wound Healing Immune Response-regulating Signaling Pathway Innate Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Signal Transduction Platelet Activation Regulation Of Immune Response Cell Migration Cellular Response To Stimulus Neurotrophin TRK Receptor Signaling Pathway Cell Activation Cellular Response To Fibroblast Growth Factor Stimulus Neurotrophin Signaling Pathway Response To Fibroblast Growth Factor Cell Motility Protein Autophosphorylation Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Blood Coagulation Cellular Response To Peptide Hormone Stimulus Hemostasis Cell Surface Receptor Signaling Pathway Response To Growth Factor Cellular Response To Peptide Immune Response Regulation Of Immune System Process Cellular Response To Organonitrogen Compound Defense Response Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Catalytic Activity Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Cell Adhesion Vascular Endothelial Growth Factor Receptor Signaling Pathway Leukocyte Migration Response To Organonitrogen Compound	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Movement Signaling Positive Regulation Of Transport Cell Communication Positive Regulation Of Organelle Organization Programmed Cell Death Regulation Of Cell Motility Cell Death Death Protein Autophosphorylation Regulation Of Cellular Component Organization Cell Activation Regulation Of Locomotion Regulation Of Cellular Ketone Metabolic Process Regulation Of Organelle Organization Positive Regulation Of Intracellular Transport Regulation Of Signaling Axonogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Catalytic Activity Cellular Localization Regulation Of Signal Transduction Apoptotic Process Regulation Of Oxidoreductase Activity Cell Development Axon Development Positive Regulation Of Signal Transduction Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cellular Localization Regulation Of Intracellular Transport Neuron Projection Development Innate Immune Response Actin Filament Organization Neuron Projection Morphogenesis Neurogenesis Positive Regulation Of Oxidoreductase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Establishment Of Protein Localization Cell Projection Organization Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Cell Adhesion Movement Of Cell Or Subcellular Component Neuron Development Regulation Of Actin Cytoskeleton Organization
Tagcloud ?		advent broadly cass4 debilitating driving emphasized fact genotypic gwas inform interacting intriguingly limit load microtubule nedd9 occurrences oncogenesis options paralogous partners pathophysiology phenotypic reciprocally reflects scaffolding snps stabilization viable
Tagcloud (Difference) ?		advent broadly cass4 debilitating driving emphasized fact genotypic gwas inform interacting intriguingly limit load microtubule nedd9 occurrences oncogenesis options paralogous partners pathophysiology phenotypic reciprocally reflects scaffolding snps stabilization viable
Tagcloud (Intersection) ?