F12 and UBE2E1

Number of citations of the paper that reports this interaction (PMID 18838541)
31

Data Source:
BioGRID (enzymatic study)

		F12	UBE2E1
Gene Name		coagulation factor XII (Hageman factor)	ubiquitin-conjugating enzyme E2E 1
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Vesicular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Misfolded Protein Binding Serine-type Aminopeptidase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity ISG15 Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Plasma Kallikrein-kinin Cascade Factor XII Activation Proteolysis Blood Coagulation Blood Coagulation, Intrinsic Pathway Positive Regulation Of Plasminogen Activation Protein Processing Protein Autoprocessing Positive Regulation Of Blood Coagulation Zymogen Activation Fibrinolysis Innate Immune Response Response To Misfolded Protein Positive Regulation Of Fibrinolysis	Protein Polyubiquitination Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Assembly Checkpoint Histone Monoubiquitination Protein Ubiquitination Cytokine-mediated Signaling Pathway Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ISG15-protein Conjugation Histone H2B Ubiquitination Negative Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Protein K48-linked Ubiquitination
Pathways		Intrinsic Pathway Formation of Fibrin Clot (Clotting Cascade)	Phosphorylation of the APC/C APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Antigen processing: Ubiquitination & Proteasome degradation Separation of Sister Chromatids Inactivation of APC/C via direct inhibition of the APC/C complex Cellular Senescence Mitotic Anaphase APC/C:Cdc20 mediated degradation of Securin M Phase Inactivation of APC/C via direct inhibition of the APC/C complex Autodegradation of Cdh1 by Cdh1:APC/C Mitotic Spindle Checkpoint Class I MHC mediated antigen processing & presentation ISG15 antiviral mechanism Interferon Signaling Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Cytokine Signaling in Immune system APC/C:Cdc20 mediated degradation of mitotic proteins Senescence-Associated Secretory Phenotype (SASP) Regulation of APC/C activators between G1/S and early anaphase Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins Antiviral mechanism by IFN-stimulated genes APC/C:Cdc20 mediated degradation of Cyclin B Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Regulation of mitotic cell cycle Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Cell Cycle Checkpoints APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881 20303064) Chronic kidney disease ( 20383146) Circulating vasoactive peptide levels ( 23381795) Metabolite levels ( 22286219 22916037) Nephrolithiasis ( 22396660) Platelet function and related traits ( 21546496)
Protein-Protein Interactions		15 interactors: APOH APP CD93 EPAS1 GP1BA KLKB1 KRT1 MMP12 MMP13 MMP14 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2N	100 interactors: ARIH2 BARD1 BIRC7 BIRC8 BRCA1 CADPS2 CBWD5 CHFR CNOT4 CUL3 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXO2 HDAC6 IPO11 ITCH JADE1 LRSAM1 MAP3K1 MARCH3 MARCH5 MARCH7 MGRN1 MID1 MKRN3 MUL1 NEDD4 NEDD4L NHLRC1 PAEP PARK2 PBX2 POLL POLM RELA RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF128 RNF13 RNF130 RNF14 RNF150 RNF152 RNF165 RNF166 RNF167 RNF168 RNF169 RNF181 RNF185 RNF2 RNF20 RNF25 RNF26 RNF4 RNF40 RNF43 RNF5 RNF8 STUB1 TOPORS TRAF6 TRIM17 TRIM2 TRIM23 TRIM27 TRIM28 TRIM32 TRIM33 TRIM37 TRIM38 TRIM39 TRIM45 TRIM50 TRIM7 UBA1 UBASH3B UBE2G1 UBE3A UBOX5 UFM1 USP7 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4
Entrez ID		2161	7324
HPRD ID		01992	04225
Ensembl ID		ENSG00000131187	ENSG00000170142
Uniprot IDs		P00748 Q8IZZ5	B7Z306 P51965
PDB IDs		4BDW 4BDX	1XR9 3BZH 4JJQ
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Blood Coagulation Negative Regulation Of Coagulation Protein Polyubiquitination Proteolysis Negative Regulation Of Wound Healing Blood Coagulation, Intrinsic Pathway Toll-like Receptor 4 Signaling Pathway Extracellular Matrix Disassembly Regulation Of Blood Coagulation Cellular Response To Hypoxia Protein Metabolic Process Cellular Response To Decreased Oxygen Levels Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Response To Hypoxia Fibrinolysis Regulation Of Wound Healing Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Extracellular Matrix Organization Extracellular Structure Organization Protein Activation Cascade Catabolic Process Positive Regulation Of Innate Immune Response Innate Immune Response Defense Response Collagen Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Plasminogen Activation Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Innate Immune Response Positive Regulation Of Ligase Activity Collagen Metabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Immune System Process Multicellular Organismal Macromolecule Metabolic Process Cellular Protein Catabolic Process Regulation Of Body Fluid Levels Protein Ubiquitination Multicellular Organismal Metabolic Process	Protein Modification By Small Protein Conjugation Protein Ubiquitination Cellular Protein Modification Process Protein Polyubiquitination Cellular Protein Metabolic Process Protein Metabolic Process Protein Autoubiquitination Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Cellular Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein K48-linked Ubiquitination Cellular Metabolic Process Protein Monoubiquitination Proteolysis Catabolic Process Metabolic Process Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Proteasomal Protein Catabolic Process Cellular Response To Stress Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Histone H2A Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Protein Ubiquitination Cellular Response To DNA Damage Stimulus Histone H2A Monoubiquitination Response To Misfolded Protein Regulation Of Signal Transduction Histone Modification Positive Regulation Of Metabolic Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Response To DNA Damage Stimulus Regulation Of Cellular Protein Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Cellular Process Positive Regulation Of Protein Catabolic Process
Tagcloud ?		amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination
Tagcloud (Difference) ?		amphotropic cem cemss clones deprived engineered episomal geneticin gp160 gp41 hut ltrs neo neomycin nonproducer packaging peculiar plj provirus retroviral retrovirus retroviruses sense ssti superinfecting superinfection syncytia therein uncleaved	array c9orf72 carriers conjugating consisting deregulation discovery displays encode except expansion frontotemporal ftd generalized grn matched preliminary proteasomal proteasome sabiosciences sporadic statistically ube2i ube2n ube2z ubiquitin ubiquitination
Tagcloud (Intersection) ?