EXT2 and GSKIP

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		EXT2	GSKIP
Gene Name		exostosin glycosyltransferase 2	GSK3B interacting protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Membrane UDP-N-acetylglucosamine Transferase Complex Extracellular Vesicular Exosome	Cytoplasm
	Molecular Function	Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity
	Biological Process	Ossification Mesoderm Formation Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Signal Transduction Pathogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Cell Differentiation Glycosaminoglycan Metabolic Process Cellular Polysaccharide Biosynthetic Process Small Molecule Metabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B Metabolism of carbohydrates MPS VII - Sly syndrome HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ANXA7 CDKN1A EXT1 GALNT5 GSKIP PFDN1 SLC22A2 SMN1 TK1 TRAP1	3 interactors: EXT2 GSK3A PEX19
Entrez ID		2132	51527
HPRD ID		00599	16601
Ensembl ID		ENSG00000151348	ENSG00000100744
Uniprot IDs		Q93063	Q9P0R6
PDB IDs			1SGO
Enriched GO Terms of Interacting Partners?		Fetal Process Involved In Parturition Cellular Metabolic Process Glycosaminoglycan Biosynthetic Process Skeletal Muscle Cell Proliferation Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Negative Regulation Of Cellular Respiration Digestive Tract Development Digestive System Development Regulation Of Reactive Oxygen Species Metabolic Process Response To Glucocorticoid Response To Corticosteroid Intestinal Epithelial Cell Maturation Glycosaminoglycan Metabolic Process Response To Toxic Substance Response To Cortisol Thymidine Metabolic Process Cellular Response To UV-B Deoxyribonucleoside Monophosphate Biosynthetic Process Choline Transport Pyrimidine Nucleoside Salvage Pyrimidine-containing Compound Salvage Anatomical Structure Development Response To Organic Cyclic Compound	Polysaccharide Metabolic Process Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Lipid Binding Negative Regulation Of Type B Pancreatic Cell Development Cellular Carbohydrate Metabolic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Positive Regulation Of Adrenergic Receptor Signaling Pathway Hypermethylation Of CpG Island Peroxisome Membrane Biogenesis Cellular Response To Interleukin-3 Positive Regulation Of Glycogen (starch) Synthase Activity Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Regulation Of Adrenergic Receptor Signaling Pathway Negative Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Protein Import Into Peroxisome Membrane Chaperone-mediated Protein Transport Peroxisomal Membrane Transport Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Glycogen Biosynthetic Process Negative Regulation Of Muscle Hypertrophy Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Glucose Import Peroxisome Fission Regulation Of Type B Pancreatic Cell Development Cardiac Left Ventricle Morphogenesis Positive Regulation Of Peptidyl-threonine Phosphorylation Negative Regulation Of Glucose Transport Cellular Response To Lithium Ion Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of DNA Methylation Negative Regulation Of Cardiac Muscle Tissue Development Protein Targeting To Peroxisome Establishment Of Protein Localization To Peroxisome Heparan Sulfate Proteoglycan Biosynthetic Process Membrane Biogenesis Regulation Of Gene Expression By Genetic Imprinting Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Heart Contraction Response To Lithium Ion Regulation Of Cardiac Muscle Hypertrophy Regulation Of Glycogen Biosynthetic Process Negative Regulation Of TOR Signaling Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Heparan Sulfate Proteoglycan Metabolic Process Genetic Imprinting Negative Regulation Of Epithelial Cell Differentiation Negative Regulation Of Organ Growth
Tagcloud ?		alters benign cartilaginous chondrocytes chondrogenesis chondrosarcoma chondrosarcomas druggable ext1 hit idh1 idh2 ihh involve late malignant notion outlining prb predisposing pthrp sarcoma scenario shifted stage summarizes thereby transformation underlies	altogether axons cadherin catenin characterize dendrites depletion differentiate downregulates emerging gsk3beta inhibiting interfering interplay negatively neurite neuroblastoma neuron outgrowth pivotal pool prevents propose raises ser396 sh specification sy5y wnt
Tagcloud (Difference) ?		alters benign cartilaginous chondrocytes chondrogenesis chondrosarcoma chondrosarcomas druggable ext1 hit idh1 idh2 ihh involve late malignant notion outlining prb predisposing pthrp sarcoma scenario shifted stage summarizes thereby transformation underlies	altogether axons cadherin catenin characterize dendrites depletion differentiate downregulates emerging gsk3beta inhibiting interfering interplay negatively neurite neuroblastoma neuron outgrowth pivotal pool prevents propose raises ser396 sh specification sy5y wnt
Tagcloud (Intersection) ?