EXT1 and TRAP1

Number of citations of the paper that reports this interaction (PMID 10545594)
10

Data Source:
HPRD (two hybrid, in vitro)

		EXT1	TRAP1
Gene Name		exostosin glycosyltransferase 1	TNF receptor-associated protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Lipid Particle Membrane Extracellular Vesicular Exosome
	Molecular Function	Acetylglucosaminyltransferase Activity Glucuronosyltransferase Activity Transferase Activity, Transferring Glycosyl Groups Heparan Sulfate N-acetylglucosaminyltransferase Activity Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase Activity N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase Activity	Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Poly(A) RNA Binding Unfolded Protein Binding
	Biological Process	Skeletal System Development Ossification Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Signal Transduction Gastrulation Axon Guidance Endoderm Development Mesoderm Development Pathogenesis Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Olfactory Bulb Development Glycosaminoglycan Metabolic Process Cellular Polysaccharide Biosynthetic Process Small Molecule Metabolic Process Embryonic Skeletal Joint Development	Response To Stress Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type Heparan sulfate/heparin (HS-GAG) metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Glycosaminoglycan metabolism Defective SLC26A2 causes chondrodysplasias Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Defective CHSY1 causes TPBS MPS IV - Morquio syndrome B Metabolism of carbohydrates MPS VII - Sly syndrome HS-GAG biosynthesis MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Height ( 19893584) Obesity-related traits ( 23251661)	Metabolite levels (HVA/5-HIAA ratio) ( 23319000)
Protein-Protein Interactions		2 interactors: EXT2 TRAP1	14 interactors: APP ESX1 EXT1 EXT2 HGS PSMC4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3
Entrez ID		2131	10131
HPRD ID		00598	05868
Ensembl ID			ENSG00000126602
Uniprot IDs		Q16394	B4DR68 F5H897 Q12931 Q53FS6
PDB IDs
Enriched GO Terms of Interacting Partners?		Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Negative Regulation Of Cellular Respiration Regulation Of Cellular Respiration Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Oxidative Stress-induced Cell Death Heparan Sulfate Proteoglycan Biosynthetic Process Heparan Sulfate Proteoglycan Metabolic Process Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Response To Oxidative Stress Proteoglycan Biosynthetic Process Chaperone-mediated Protein Folding Regulation Of Reactive Oxygen Species Biosynthetic Process Regulation Of Generation Of Precursor Metabolites And Energy Polysaccharide Metabolic Process Mesoderm Formation Mesoderm Morphogenesis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Glycosaminoglycan Biosynthetic Process Proteoglycan Metabolic Process Formation Of Primary Germ Layer Mesoderm Development Carbohydrate Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Glycosaminoglycan Metabolic Process Gastrulation Pathogenesis	Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cellular Localization Signal Transduction Embryonic Morphogenesis Regulation Of Protein Phosphorylation Heparan Sulfate Proteoglycan Biosynthetic Process, Polysaccharide Chain Biosynthetic Process Embryo Development Signaling Positive Regulation Of Metabolic Process Cell Communication Positive Regulation Of Cellular Metabolic Process Detection Of Bacterial Lipoprotein Chordate Embryonic Development Regulation Of Protein Localization Embryo Development Ending In Birth Or Egg Hatching Gastrulation Regulation Of Phosphorylation Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Protein Modification Process In Utero Embryonic Development Endothelial Cell Activation Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Cellular Response To Stimulus Regulation Of Signaling Positive Regulation Of Interleukin-6 Biosynthetic Process Programmed Cell Death Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of SMAD Protein Import Into Nucleus Cell Death Death Detection Of Molecule Of Bacterial Origin Cellular Response To Bacterial Lipopeptide Regulation Of Protein Transport Anatomical Structure Morphogenesis Positive Regulation Of Protein Import Into Nucleus Regulation Of SMAD Protein Import Into Nucleus Regulation Of Interleukin-6 Production Pathway-restricted SMAD Protein Phosphorylation Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Proliferation Palate Development Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Activation Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport
Tagcloud ?		alters benign cartilaginous chondrocytes chondrogenesis chondrosarcoma chondrosarcomas druggable ext2 hit idh1 idh2 ihh involve late malignant notion outlining prb predisposing pthrp sarcoma scenario shifted stage summarizes thereby transformation underlies	apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic
Tagcloud (Difference) ?		alters benign cartilaginous chondrocytes chondrogenesis chondrosarcoma chondrosarcomas druggable ext2 hit idh1 idh2 ihh involve late malignant notion outlining prb predisposing pthrp sarcoma scenario shifted stage summarizes thereby transformation underlies	apg1 forelimb forelimbs grp94 hindlimb hindlimbs hsp10 hsp105 hsp110 hsp20 hsp22 hsp25 hsp47 hsp60 hspa12a hspa12b hspa13 hspa14 hspa1l hspb10 hspb2 hspb3 hspb4 hspb7 hspb9 hsps oligodactylic performs phocomelic
Tagcloud (Intersection) ?