ESRRG and NR0B1

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid, two hybrid)

		ESRRG	NR0B1
Gene Name		estrogen-related receptor gamma	nuclear receptor subfamily 0, group B, member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Membrane Polysomal Ribosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Steroid Hormone Receptor Activity Retinoic Acid Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding AF-2 Domain Binding	DNA Binding Steroid Hormone Receptor Activity Transcription Corepressor Activity RNA Binding Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding DNA Hairpin Binding Steroid Hormone Receptor Binding Protein Homodimerization Activity Sequence-specific DNA Binding AF-2 Domain Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Gene Expression Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Retinoic Acid Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Steroid Biosynthetic Process Spermatogenesis Protein Localization Gonad Development Male Gonad Development Gene Expression Hypothalamus Development Pituitary Gland Development Male Sex Determination Adrenal Gland Development Intracellular Receptor Signaling Pathway Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Leydig Cell Differentiation Response To Immobilization Stress Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Sertoli Cell Differentiation
Pathways		Generic Transcription Pathway Nuclear Receptor transcription pathway
Drugs			Tretinoin Dexamethasone
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (all antimicrotubule drugs) ( 23648065) Alcohol consumption ( 23743675) Cardiac hypertrophy ( 21348951) Dialysis-related mortality ( 21546767) Major depressive disorder ( 23377640) Optic disc size (cup) ( 20395239)
Protein-Protein Interactions		30 interactors: APP ARHGEF15 CALM1 CCDC67 DAXX DPF2 DUT EBP EIF3I ESRRA HGS KIAA1598 KIFC3 MEOX2 NCOA1 NR0B1 NR0B2 NRIP1 NUP160 PNRC1 PNRC2 PPARGC1A PPARGC1B PROX1 SP1 SRA1 SRC SRPK1 SUMO1P1 TLE1	16 interactors: AR COPS2 ESR1 ESR2 ESRRA ESRRG NR3C1 NR5A1 NRIP1 PGR POU5F1 PPARG RNF31 RORA SNW1 SREBF1
Entrez ID		2104	190
HPRD ID		04274	08362
Ensembl ID		ENSG00000196482
Uniprot IDs		B7Z5E9 C0SQ93 F1D8R5 F1D8R6 P62508	F1D8P4 P51843
PDB IDs		1KV6 1TFC 1VJB 2E2R 2EWP 2GP7 2GPO 2GPP 2GPU 2GPV 2P7A 2P7G 2P7Z 2ZAS 2ZBS 2ZKC
Enriched GO Terms of Interacting Partners?		Intracellular Receptor Signaling Pathway Gene Expression RNA Metabolic Process RNA Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Transcription, DNA-templated Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Androgen Receptor Signaling Pathway Developmental Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Organ Development Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Cellular Biosynthetic Process Anatomical Structure Development Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription System Development Negative Regulation Of RNA Biosynthetic Process Response To Lipid Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Cyclic Compound DNA-templated Transcription, Initiation Regulation Of Cellular Process Signaling Response To Hormone Steroid Metabolic Process Regulation Of Receptor Activity Cell Communication	Intracellular Receptor Signaling Pathway Steroid Hormone Mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Hormone-mediated Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Lipid Cellular Response To Steroid Hormone Stimulus Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Response To Lipid Cellular Response To Organic Cyclic Compound Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Response To Organic Cyclic Compound Response To Hormone RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Signal Transduction Cellular Response To Organic Substance Signaling Positive Regulation Of Cellular Metabolic Process Cell Communication Nucleobase-containing Compound Metabolic Process Rhythmic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Organ Development Cellular Nitrogen Compound Metabolic Process Cellular Response To Stimulus System Development Response To Organic Substance Ovulation Cycle Process Nitrogen Compound Metabolic Process
Tagcloud ?		aging analyzing apoa apob apoe b10 block c3 c57br chr deposits evolvement glomerular glomeruli gpatch2 haplotype inbred influencing intracapillary kctd3 mapping nzw pas perilipin reponses spanning spata17 ush2a weakly	always cd99 chondrosarcoma comprising differentiate diffuse e2f3 es ewing ewsr1 exceptional extraskeletal fli1 gold immunohistochemical marker merkel mesenchymal myxoid neoplasm neuroblastomas nkx2 olfactory powerful reinforces round sarcoma singly srcts
Tagcloud (Difference) ?		aging analyzing apoa apob apoe b10 block c3 c57br chr deposits evolvement glomerular glomeruli gpatch2 haplotype inbred influencing intracapillary kctd3 mapping nzw pas perilipin reponses spanning spata17 ush2a weakly	always cd99 chondrosarcoma comprising differentiate diffuse e2f3 es ewing ewsr1 exceptional extraskeletal fli1 gold immunohistochemical marker merkel mesenchymal myxoid neoplasm neuroblastomas nkx2 olfactory powerful reinforces round sarcoma singly srcts
Tagcloud (Intersection) ?