CLN8 and ZUFSP

Number of citations of the paper that reports this interaction (PMID 23142642)
0

Data Source:
BioGRID (two hybrid)

		CLN8	ZUFSP
Gene Name		ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation)	zinc finger with UFM1-specific peptidase domain
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function		Metal Ion Binding
	Biological Process	Age-dependent Response To Oxidative Stress Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Regulation Of Cell Size Lipid Biosynthetic Process Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Apoptotic Process Cellular Protein Catabolic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Negative Regulation Of Transferase Activity L-glutamate Uptake Involved In Synaptic Transmission Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization
Pathways
Drugs
Diseases
GWAS		Gaucher disease severity ( 22388998)
Protein-Protein Interactions		29 interactors: ARL6IP5 BNIP3 BNIP3L C14orf1 CD9 CYB5B GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC YIPF6 ZUFSP	4 interactors: CLN8 PRMT5 RPS21 SHCBP1
Entrez ID		2055	221302
HPRD ID		06383	12840
Ensembl ID		ENSG00000182372	ENSG00000153975
Uniprot IDs		Q9UBY8	Q96AP4
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Protein Catabolic Process Transport Membrane Organization Apoptotic Signaling Pathway Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Establishment Of Localization In Cell Negative Regulation Of Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Membrane Fusion Apoptotic Process Cellular Localization Programmed Cell Death Cell Death Death Mitochondrial Transport Organelle Organization Intracellular Transport Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Oligodendrocyte Development Substantia Nigra Development Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway Response To Stress Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Neural Nucleus Development Gliogenesis Mitochondrial Membrane Organization Protein Transport Dense Core Granule Maturation Apoptotic Mitochondrial Changes Positive Regulation Of Apoptotic Process Oligodendrocyte Differentiation Establishment Of Protein Localization Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Cellular Response To Stress Regulation Of Branching Morphogenesis Of A Nerve Negative Regulation Of Serotonin Uptake Midbrain Development Glial Cell Development Cellular Response To Hypoxia Cell Communication Cellular Response To Decreased Oxygen Levels Negative Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Fusion Granzyme-mediated Apoptotic Signaling Pathway	Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine L-glutamate Uptake Involved In Synaptic Transmission Endonucleolytic Cleavage To Generate Mature 3'-end Of SSU-rRNA From (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Endonucleolytic Cleavage In ITS1 To Separate SSU-rRNA From 5.8S RRNA And LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Age-dependent Response To Oxidative Stress RRNA 3'-end Processing Ribonucleoprotein Complex Biogenesis Somatic Motor Neuron Differentiation L-glutamate Import Histone H4-R3 Methylation Endothelial Cell Activation Neurotransmitter Uptake Maturation Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) NcRNA Metabolic Process Neurofilament Cytoskeleton Organization Neuromuscular Process Controlling Posture Peptidyl-arginine N-methylation Amino Acid Import Maturation Of 5.8S RRNA MRNA Metabolic Process Histone Arginine Methylation RNA Processing Peptidyl-arginine Methylation Maturation Of SSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) L-glutamate Transport Maturation Of SSU-rRNA Photoreceptor Cell Maintenance Ribosomal Small Subunit Biogenesis Intermediate Filament Cytoskeleton Organization Social Behavior Spliceosomal SnRNP Assembly Intermediate Filament-based Process Musculoskeletal Movement Cellular Macromolecule Catabolic Process Membrane Organization Spinal Cord Motor Neuron Differentiation Adult Walking Behavior Ceramide Biosynthetic Process Lysosome Organization Ventral Spinal Cord Development Retina Homeostasis Mitochondrial Membrane Organization
Tagcloud ?		brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Difference) ?		brainstem ceroid cln6 connectivity displayed epilepsy exclusively flurothyl generalized infantile kindled kindling latencies latency lipofuscinoses mnd nclf neuronal northern phenotypes plasticity postnatal posture reexposed repeated retesting seizure seizures shared
Tagcloud (Intersection) ?