EPB41L2 and SPTAN1

Number of citations of the paper that reports this interaction (PMID 12044158)
17

Data Source:
HPRD (in vitro)

		EPB41L2	SPTAN1
Gene Name		erythrocyte membrane protein band 4.1-like 2	spectrin, alpha, non-erythrocytic 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Focal Adhesion Spectrin COP9 Signalosome Extrinsic Component Of Membrane Cell Junction Extracellular Vesicular Exosome	Cytosol Fascia Adherens Spectrin Microtubule Cytoskeleton Membrane Lateral Plasma Membrane Z Disc Vesicle Cuticular Plate Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome
	Molecular Function	Actin Binding Structural Molecule Activity PH Domain Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Spectrin Binding Protein Heterodimerization Activity
	Biological Process	Cortical Actin Cytoskeleton Organization	Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Axon Guidance Actin Filament Capping
Pathways			Interaction between L1 and Ankyrins Apoptotic cleavage of cellular proteins Axon guidance Programmed Cell Death Apoptotic execution phase Nephrin interactions L1CAM interactions Caspase-mediated cleavage of cytoskeletal proteins NCAM signaling for neurite out-growth
Drugs
Diseases
GWAS		Lentiform nucleus volume ( 22903471) Response to statin therapy (LDL-C) ( 22331829)
Protein-Protein Interactions		13 interactors: ACTA1 ADORA1 APP ATXN1L DRD1 DRD3 FKBP2 GRIA1 NUMA1 SPTAN1 YWHAG YWHAH YWHAZ	48 interactors: ABI1 ABL1 ACP1 ACTA1 ACTB ADD1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES DISC1 EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D MAPK6 NEFL PIN4 PLEC PLEKHA5 PRKCB PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SRC STAT1 SYN1 TANC1 TES TSSC4
Entrez ID		2037	6709
HPRD ID		09126	01684
Ensembl ID		ENSG00000079819	ENSG00000197694
Uniprot IDs		B4DJ76 E9PHY5 E9PII3 I6L9B1 O43491 O60642 Q59FD8	Q13813
PDB IDs			2FOT 3F31 3FB2
Enriched GO Terms of Interacting Partners?		Regulation Of Synaptic Transmission Regulation Of Synaptic Plasticity Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Cognition Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Transport Positive Regulation Of Mitochondrion Organization System Development Visual Learning Negative Regulation Of Synaptic Transmission Visual Behavior Neuron-neuron Synaptic Transmission Apoptotic Process Positive Regulation Of Intracellular Transport Programmed Cell Death Regulation Of Cellular Localization Cell Death Death Learning Or Memory Regulation Of Dopamine Uptake Involved In Synaptic Transmission Associative Learning Multicellular Organismal Development Regulation Of Mitochondrion Organization Anatomical Structure Development Synaptic Transmission, Dopaminergic Behavioral Response To Cocaine Apoptotic Signaling Pathway Regulation Of Neurotransmitter Uptake Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Establishment Of Localization In Cell Prepulse Inhibition Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Regulation Of Circadian Sleep/wake Cycle, Sleep Long Term Synaptic Depression Regulation Of Synaptic Transmission, Dopaminergic Neuromuscular Process Positive Regulation Of Organelle Organization Learning Regulation Of Signaling Regulation Of Anion Transport Protein Targeting Developmental Process Regulation Of Renal Sodium Excretion G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Intracellular Transport Nervous System Development Intracellular Transport Cell-cell Signaling Regulation Of Excretion	Cell Morphogenesis Neuron Projection Morphogenesis Neuron Projection Development Cell Projection Organization Axon Development Cell Projection Morphogenesis Cell Development Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Morphogenesis Involved In Neuron Differentiation Cytoskeleton Organization Neuron Differentiation Neuron Development Axon Guidance Cell Differentiation Neurogenesis Anatomical Structure Morphogenesis Generation Of Neurons Axonogenesis Neuromuscular Process Movement Of Cell Or Subcellular Component Ionotropic Glutamate Receptor Signaling Pathway Chemotaxis Organelle Organization System Development Synaptic Transmission, Glutamatergic Response To External Stimulus Anatomical Structure Development Homeostatic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Locomotion Glutamate Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nervous System Development Membrane Depolarization Synaptic Transmission Neuron-neuron Synaptic Transmission Cellular Component Assembly Startle Response Actin Filament-based Process Developmental Process Regulation Of Excitatory Postsynaptic Membrane Potential Learning Multicellular Organismal Development Regulation Of Postsynaptic Membrane Potential Signaling Response To Wounding Cell Communication Cellular Response To Stimulus
Tagcloud ?			adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Difference) ?			adenocarcinomas atxn2 biology consistently couple deregulation dhx9 driver exome hundreds kras mutations myof never overlap preferentially ptpn13 recurrent respective rps6kb2 seq sequenced smokers somatic sp1 stratification targetable ten thousands
Tagcloud (Intersection) ?