EPAS1 and BBS2

Number of citations of the paper that reports this interaction (PMID 18000879)
5

Data Source:
BioGRID (two hybrid)

		EPAS1	BBS2
Gene Name		endothelial PAS domain protein 1	Bardet-Biedl syndrome 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex Cytosol	Cytosol Motile Cilium BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Signal Transducer Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Protein Heterodimerization Activity	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding
	Biological Process	Angiogenesis Response To Hypoxia Embryonic Placenta Development Blood Vessel Remodeling Regulation Of Heart Rate Transcription From RNA Polymerase II Promoter Mitochondrion Organization Signal Transduction Visual Perception Erythrocyte Differentiation Lung Development Somatic Stem Cell Maintenance Norepinephrine Metabolic Process Surfactant Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Maturation Myoblast Fate Commitment Iron Ion Homeostasis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia	Organelle Organization Sperm Axoneme Assembly Visual Perception Protein Localization Negative Regulation Of Gene Expression Artery Smooth Muscle Contraction Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Melanosome Transport Protein Localization To Organelle Nonmotile Primary Cilium Assembly Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Vasodilation Golgi To Plasma Membrane Protein Transport Fat Cell Differentiation Photoreceptor Cell Maintenance Brain Morphogenesis Cartilage Development Cilium Morphogenesis Regulation Of Cilium Beat Frequency Involved In Ciliary Motility
Pathways		Cellular response to hypoxia Transcriptional regulation of pluripotent stem cells Regulation of Hypoxia-inducible Factor (HIF) by oxygen Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent asparagine hydroxylation of Hypoxia-inducible Factor Alpha Regulation of gene expression by Hypoxia-inducible Factor	Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Assembly of the primary cilium BBSome-mediated cargo-targeting to cilium
Drugs
Diseases
GWAS		Renal cell carcinoma ( 21131975)
Protein-Protein Interactions		32 interactors: APC ARNT ARNT2 ARNTL ARNTL2 BATF BATF2 BATF3 BBS1 BBS2 BBS4 DBP DDIT3 EGLN1 EGLN2 EGLN3 EIF3E EP300 EWSR1 F12 HSP90AA1 JUN KLHL20 MAX MEF2C NDN PRKD1 SMAD3 SPP1 STAT5A TERF2IP VHL	11 interactors: BHMT EEF1A1 EPAS1 EXOC7 FHOD1 HSCB KRT18 MDFI PAX2 PSME3 RBPMS
Entrez ID		2034	583
HPRD ID		06787	05855
Ensembl ID		ENSG00000116016	ENSG00000125124
Uniprot IDs		B3KW07 Q99814	Q9BXC9
PDB IDs		1P97 2A24 3F1N 3F1O 3F1P 3H7W 3H82 4GHI 4GS9
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stress Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Stress Response To Stimulus Anatomical Structure Development Transcription, DNA-templated Regulation Of RNA Metabolic Process RNA Biosynthetic Process System Development Developmental Process Nitrogen Compound Metabolic Process RNA Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Response To Hypoxia Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Cellular Response To Oxygen Levels Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Response To Organic Substance Positive Regulation Of Gene Expression Cellular Response To Stimulus Positive Regulation Of Metabolic Process Organ Development Negative Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process Leukocyte Activation Biosynthetic Process Leukocyte Differentiation Response To External Stimulus Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Myeloid Leukocyte Differentiation	Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Optic Chiasma Development Positive Regulation Of Optic Nerve Formation Golgi To Plasma Membrane CFTR Protein Transport Pronephric Field Specification Optic Nerve Structural Organization Negative Regulation Of Apoptotic Process Involved In Metanephric Collecting Duct Development Negative Regulation Of Apoptotic Process Involved In Metanephric Nephron Tubule Development Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephric Nephron Morphogenesis Positive Regulation Of Metanephric DCT Cell Differentiation Regulation Of Metanephros Size S-methylmethionine Cycle S-methylmethionine Metabolic Process Embryonic Organ Development Embryonic Placenta Development Amino-acid Betaine Catabolic Process Regulation Of Homocysteine Metabolic Process Negative Regulation Of Cytolysis Kidney Rudiment Formation Paramesonephric Duct Development Vestibulocochlear Nerve Formation Metanephric Nephron Tubule Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Nephron Morphogenesis Regulation Of Kidney Size Positive Regulation Of Metabolic Process Positive Regulation Of Metanephric Glomerulus Development Nephric Duct Formation Metanephric Mesenchymal Cell Differentiation Ureter Morphogenesis Metanephric Tubule Formation Ureter Maturation Regulation Of Protein Import Into Nucleus Visual Perception Sensory Perception Of Light Stimulus Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Mesodermal Cell Fate Specification Myoblast Fate Commitment Placenta Development Negative Regulation Of Wnt Signaling Pathway Metanephric Distal Convoluted Tubule Development Metanephric Nephron Tubule Morphogenesis Regulation Of Protein Localization To Nucleus Cellular Response To Oxidative Stress Cellular Response To Stress Developmental Process Involved In Reproduction Optic Cup Morphogenesis Involved In Camera-type Eye Development
Tagcloud ?		2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	actr1a backgrounds bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Difference) ?		2alpha adaptation adapted altitude another approaches basis concert egln1 encodes hif hif2a humans hydroxylase hypoxia inducible locations offer orchestrates phd2 populations prolyl regulators signatures tibetans toward treating unraveling wide	actr1a backgrounds bovines c2orf29 cnot7 cq cycling dnajc17 endometrium establishes friesian gapdh genorm holstein normalise normalised normfinder oestrus oxtr oxytocin ppia ranbp10 rps15a rps9 slc30a6 suitability suz12 uxt znf131
Tagcloud (Intersection) ?