EIF4G2 and EIF4E

Number of citations of the paper that reports this interaction (PMID 10394359)
93

Data Source:
HPRD (in vitro)

		EIF4G2	EIF4E
Gene Name		eukaryotic translation initiation factor 4 gamma, 2	eukaryotic translation initiation factor 4E
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex	Cytoplasmic MRNA Processing Body Cytoplasm Cytosol MRNA Cap Binding Complex Cytoplasmic Stress Granule Eukaryotic Translation Initiation Factor 4F Complex RISC Complex Chromatoid Body Extracellular Vesicular Exosome
	Molecular Function	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding	RNA Cap Binding Translation Initiation Factor Activity Protein Binding Eukaryotic Initiation Factor 4G Binding Poly(A) RNA Binding
	Biological Process	Translational Initiation Regulation Of Translational Initiation Cell Cycle Arrest Cell Death Cytokine-mediated Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Export From Nucleus Translation Translational Initiation Regulation Of Translation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Lung Development Cellular Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Translation initiation complex formation IRS-mediated signalling mTOR signalling Transport of the SLBP independent Mature mRNA mTOR signalling mTORC1-mediated signalling IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation Release of eIF4E Transport of Mature Transcript to Cytoplasm Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Transport of Mature mRNA Derived from an Intronless Transcript Processing of Capped Intron-Containing Pre-mRNA Transport of the SLBP Dependant Mature mRNA Insulin receptor signalling cascade Deadenylation of mRNA Translation Transport of Mature mRNA derived from an Intron-Containing Transcript ISG15 antiviral mechanism Transport of Mature mRNAs Derived from Intronless Transcripts Interferon Signaling Cytokine Signaling in Immune system IRS-related events Release of eIF4E L13a-mediated translational silencing of Ceruloplasmin expression Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade
Drugs			7-Methyl-Gpppa 7n-Methyl-8-Hydroguanosine-5\'-Diphosphate 7-Methyl-Guanosine-5\'-Triphosphate 2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL
Diseases
GWAS
Protein-Protein Interactions		11 interactors: CASP3 EIF2S2 EIF3A EIF4A1 EIF4A2 EIF4E EIF5 MKNK1 NCBP1 RPA2 SKIL	25 interactors: APP CD83 EIF4B EIF4EBP1 EIF4EBP2 EIF4EBP3 EIF4ENIF1 EIF4G1 EIF4G2 EIF4G3 EMX2 GEMIN5 KANK2 MAPKAPK5 MKNK1 MKNK2 PML PRDM4 PRKCA PRKCB PRKCG RPS6KA5 TDO2 TRIM27 UBXN11
Entrez ID		1982	1977
HPRD ID		09084	00591
Ensembl ID		ENSG00000110321
Uniprot IDs		P78344 Q2TU89	P06730 Q32Q75
PDB IDs		3D3M 3L6A 4IUL	1IPB 1IPC 1WKW 2GPQ 2V8W 2V8X 2V8Y 2W97 3AM7 3TF2 3U7X 4AZA 4DT6 4DUM
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Translational Initiation Regulation Of Translation Aromatic Compound Catabolic Process Posttranscriptional Regulation Of Gene Expression MRNA 3'-end Processing RNA 3'-end Processing Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Cellular Macromolecule Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Cellular Protein Metabolic Process Response To Cytokine Regulation Of Protein Metabolic Process Nuclear Export Gene Expression Biosynthetic Process MRNA Processing Catabolic Process MRNA Metabolic Process Cellular Response To Organic Substance Viral Process Cellular Metabolic Process RNA Processing Nucleocytoplasmic Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Nuclear Transport Response To Organic Substance MRNA Export From Nucleus Lymphocyte Homeostasis Negative Regulation Of RNA-directed RNA Polymerase Activity RNA Export From Nucleus Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Cycle Protein Metabolic Process Leukocyte Homeostasis Regulation Of Metabolic Process Negative Regulation Of Cell Cycle Cytokine-mediated Signaling Pathway Extrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Cell Surface Receptor Signaling Pathway MRNA Transport Nucleobase-containing Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus	Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Response To Organic Substance Regulation Of Gene Expression Cell Surface Receptor Signaling Pathway Cellular Protein Metabolic Process Signal Transduction Protein Phosphorylation Signaling Cell Communication Regulation Of Metabolic Process Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Translational Initiation Histone H3-T6 Phosphorylation Gene Expression Negative Regulation Of Translation Negative Regulation Of Protein Metabolic Process Protein Metabolic Process Translational Initiation Cellular Response To Stimulus Cell Death Death Phosphorylation Intracellular Signal Transduction Histone Phosphorylation Insulin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cellular Metabolic Process Response To Growth Factor Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Apoptotic Process Platelet Activation Translation Programmed Cell Death Regulation Of Mitotic Cell Cycle Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Cytokine Neurotrophin Signaling Pathway MRNA 3'-end Processing Cytokine-mediated Signaling Pathway
Tagcloud ?		11p15 4f backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo	4g amount bp1 corticosterone decreases deficiency diazoxide diminished dramatic efficiency eif4g epitrochlearis eukaryotic fractional gastrocnemius glucagon hormones initiation injection lowered modulating muscle postprandial ribosomal skeletal soleus synthesis translation
Tagcloud (Difference) ?		11p15 4f backcross blot casein codes conserved contains copy exhibits frame germ glycosylation homology interspecific iso northern p82 polypeptide reading segment similarity southern syntenic ubiquitously vertebrates wheat zoo	amount bp1 corticosterone decreases deficiency diazoxide diminished dramatic efficiency eif4g epitrochlearis eukaryotic fractional gastrocnemius glucagon hormones initiation injection lowered modulating muscle postprandial ribosomal skeletal soleus synthesis translation
Tagcloud (Intersection) ?		4g