ARID2 and CCNA1

Number of citations of the paper that reports this interaction (PMID 15159402)
12

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		ARID2	CCNA1
Gene Name		AT rich interactive domain 2 (ARID, RFX-like)	cyclin A1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Plasma Membrane	Nucleoplasm Cytosol Microtubule Cytoskeleton
	Molecular Function	DNA Binding Protein Binding Metal Ion Binding	Protein Binding Protein Kinase Binding
	Biological Process	Nucleosome Disassembly Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chromatin Modification	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Mitotic Nuclear Division Male Meiosis I Spermatogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Division
Pathways		Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines	Cellular Senescence G2/M Transition Cyclin E associated events during G1/S transition Orc1 removal from chromatin Cyclin A/B1 associated events during G2/M transition G2 Phase G1/S Transition G1/S-Specific Transcription Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication DNA Damage/Telomere Stress Induced Senescence Synthesis of DNA Regulation of DNA replication Senescence-Associated Secretory Phenotype (SASP) APC/C:Cdc20 mediated degradation of mitotic proteins G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes S Phase Regulation of APC/C activators between G1/S and early anaphase Cell Cycle, Mitotic APC/C-mediated degradation of cell cycle proteins SCF(Skp2)-mediated degradation of p27/p21 Orc1 removal from chromatin Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Regulation of mitotic cell cycle APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint SCF(Skp2)-mediated degradation of p27/p21 Cyclin A:Cdk2-associated events at S phase entry Mitotic G2-G2/M phases
Drugs
Diseases
GWAS		Hippocampal atrophy ( 19668339)
Protein-Protein Interactions		4 interactors: CCNA1 NFYC SMARCA4 SMARCE1	34 interactors: ARID2 BRCA1 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GNB2L1 GPS2 HIST1H1A HIST1H1B HIST1H2BA INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6
Entrez ID		196528	8900
HPRD ID		16505	04946
Ensembl ID		ENSG00000189079	ENSG00000133101
Uniprot IDs		Q68CP9	P78396
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleosome Disassembly Regulation Of Transcription From RNA Polymerase II Promoter ATP-dependent Chromatin Remodeling Nucleosome Organization Chromatin Assembly Or Disassembly Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Chromatin Remodeling Protein Complex Disassembly Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition DNA Methylation On Cytosine Within A CG Sequence Definitive Erythrocyte Differentiation Aortic Smooth Muscle Cell Differentiation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Glial Cell Fate Determination Methylation-dependent Chromatin Silencing Regulation Of RNA Metabolic Process Positive Regulation By Host Of Viral Transcription Regulation Of Mitotic Cell Cycle Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process DNA Methylation On Cytosine Negative Regulation Of Androgen Receptor Signaling Pathway Regulation Of Cell Cycle Process Blastocyst Hatching Heart Trabecula Formation Lens Fiber Cell Development Vascular Smooth Muscle Cell Differentiation Regulation Of Androgen Receptor Signaling Pathway Chromatin Modification Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Glial Cell Fate Commitment Definitive Hemopoiesis Heart Trabecula Morphogenesis Blastocyst Growth Male Meiosis I Chromatin Organization Interaction With Symbiont Chromatin Silencing Lens Fiber Cell Differentiation Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of DNA Binding Epidermis Morphogenesis Regulation Of G2/M Transition Of Mitotic Cell Cycle Histone H3 Acetylation Positive Regulation Of Viral Transcription Regulation Of Cell Cycle G2/M Phase Transition Trabecula Morphogenesis	Cell Cycle G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Mitotic Cell Cycle Regulation Of Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process Regulation Of Kinase Activity Chromosome Organization Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Organelle Organization Negative Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Cell Cycle Checkpoint Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Kinase Activity Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Negative Regulation Of Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression DNA Damage Checkpoint Positive Regulation Of Metabolic Process DNA Replication Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Gene Expression DNA Conformation Change Cell Division Mitotic Cell Cycle Checkpoint Positive Regulation Of Transcription, DNA-templated Regulation Of Protein Phosphorylation Positive Regulation Of Cell Cycle Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Cell Cycle Negative Regulation Of Transferase Activity Regulation Of Catalytic Activity Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Protein Metabolic Process
Tagcloud ?		aberrations applying axin1 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs	asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts
Tagcloud (Difference) ?		aberrations applying axin1 cdk15 cps1 creating deleterious disruptions drive driver fn1 fusions genomes hccs hnf4a integrations intronic mll4 recurrently rps6ka3 seq silent splice tert thrap3 transcriptomes transcriptomic tsc1 wgs	asparaginase axis clustered confirming cure dexamethasone enhancement harboring hoxa infant lineage lymphoblastic meis1 mll nutlin oncogene orally recapitulate regimen regressions remission rg7112 translocations uncommon utility vincristine warrants xenograft xenografts
Tagcloud (Intersection) ?