EGR1 and NAB1

Number of citations of the paper that reports this interaction (PMID 7624335)
58

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		EGR1	NAB1
Gene Name		early growth response 1	NGFI-A binding protein 1 (EGR1 binding protein 1)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm	Nucleus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Metal Ion Binding	Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Amphetamine Transcription From RNA Polymerase II Promoter Learning Or Memory Circadian Rhythm Response To Glucose Cytokine-mediated Signaling Pathway T Cell Differentiation BMP Signaling Pathway Response To Nutrient Levels Cellular Response To Insulin Stimulus Regulation Of Protein Sumoylation Response To Carbon Monoxide Cellular Response To Drug Skeletal Muscle Cell Differentiation Response To Cocaine Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Long-term Neuronal Synaptic Plasticity Oligodendrocyte Differentiation Response To Electrical Stimulus Long-term Synaptic Potentiation Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Cellular Response To Antibiotic Cellular Response To Mechanical Stimulus Cellular Response To Isoquinoline Alkaloid Cellular Response To CAMP Cellular Response To Growth Factor Stimulus Cellular Response To Gonadotropin Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Steroid Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Hypoxia Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Response To Norepinephrine Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Endochondral Ossification Transcription, DNA-templated Regulation Of Transcription, DNA-templated Schwann Cell Differentiation Myelination Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated
Pathways		Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: CDKN2A CEBPB CREBBP CSNK2A1 EP300 ERBB3 IL1B JUN NAB1 NAB2 NFATC1 NFATC2 PITX1 PSMA3 RELA SP1 SRA1 SREBF2 TP53 WT1	2 interactors: EGR1 POU2AF1
Entrez ID		1958	4664
HPRD ID		00549	02881
Ensembl ID		ENSG00000120738	ENSG00000138386
Uniprot IDs		P18146 Q546S1	B8ZZS2 Q13506
PDB IDs			2YUF
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Gene Expression Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Metabolic Process RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Macromolecule Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Apoptotic Process Cell Differentiation Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Regulation Of Cell Death Developmental Process Negative Regulation Of Apoptotic Process Immune System Process Negative Regulation Of Programmed Cell Death Immune Response Negative Regulation Of Cell Death Cellular Metabolic Process Positive Regulation By Host Of Viral Transcription Anatomical Structure Morphogenesis	Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Cellular Response To Mycophenolic Acid Response To Carbon Monoxide Positive Regulation Of Glomerular Mesangial Cell Proliferation Glomerular Mesangial Cell Proliferation Cellular Response To Heparin Cellular Response To Isoquinoline Alkaloid Positive Regulation Of Metanephric Glomerulus Development Response To Heparin Response To Norepinephrine Positive Regulation Of Cell Proliferation Involved In Kidney Development Regulation Of Glomerular Mesangial Cell Proliferation Cellular Response To Hyperoxia Positive Regulation Of Glomerulus Development Cell Proliferation Involved In Kidney Development Cellular Response To Follicle-stimulating Hormone Stimulus Transcription From RNA Polymerase II Promoter Interleukin-1-mediated Signaling Pathway Cellular Response To Gamma Radiation Regulation Of Protein Sumoylation Cellular Response To Antibiotic Glomerulus Vasculature Development Response To Follicle-stimulating Hormone Cellular Response To Toxic Substance Cellular Response To Gonadotropin Stimulus Regulation Of Long-term Neuronal Synaptic Plasticity Response To Hyperoxia Response To Amphetamine Immune Response Positive Regulation Of Kidney Development Cellular Response To Alkaloid Response To Gonadotropin Response To Electrical Stimulus Cellular Response To CAMP Response To Cocaine Long-term Synaptic Potentiation Response To Amine Response To Gamma Radiation Cellular Response To Drug Regulation Of Neuronal Synaptic Plasticity Cellular Response To Interleukin-1 Cellular Response To Ionizing Radiation Response To Antibiotic Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Apoptotic Process Glomerulus Development Cellular Response To Mechanical Stimulus Positive Regulation Of Neuron Death BMP Signaling Pathway Oligodendrocyte Differentiation
Tagcloud ?		acidic acts astrocyte astrocytes astrocytosis capable cascade controlling decreases exhibits fibrillary gfap glial hiv immunodeficiency importantly indirect nervous neurological neurotoxicity pathogenic roles sequential stat3 tat transactivation transducer upstream	acetylated actinomycin construct correlates downregulation egr egr3 h4 histones ifn ifngr ifngr1 ifns luc macrophage macrophages myeloid ngfi pol prevented promoter rapid reductions reflect repressive responsiveness silences silencing
Tagcloud (Difference) ?		acidic acts astrocyte astrocytes astrocytosis capable cascade controlling decreases exhibits fibrillary gfap glial hiv immunodeficiency importantly indirect nervous neurological neurotoxicity pathogenic roles sequential stat3 tat transactivation transducer upstream	acetylated actinomycin construct correlates downregulation egr3 h4 histones ifn ifngr ifngr1 ifns luc macrophage macrophages myeloid ngfi pol prevented promoter rapid reductions reflect repressive responsiveness silences silencing
Tagcloud (Intersection) ?		egr