EGF and ERBB2

Number of citations of the paper that reports this interaction (PMID 12093292)
1

Data Source:
HPRD (in vitro)

		EGF	ERBB2
Gene Name		epidermal growth factor	erb-b2 receptor tyrosine kinase 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Platelet Alpha Granule Lumen Extracellular Vesicular Exosome	Nucleus Cytoplasm Plasma Membrane Endosome Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cytoplasmic Vesicle Receptor Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Growth Factor Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity	RNA Polymerase I Core Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Transmembrane Signaling Receptor Activity Protein Binding ATP Binding Protein C-terminus Binding Growth Factor Binding Protein Phosphatase Binding Identical Protein Binding ErbB-3 Class Receptor Binding Protein Heterodimerization Activity Protein Dimerization Activity
	Biological Process	Activation Of MAPKK Activity Angiogenesis Platelet Degranulation DNA Replication Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway STAT Protein Import Into Nucleus Blood Coagulation Positive Regulation Of Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-threonine Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Platelet Activation Positive Regulation Of Catenin Import Into Nucleus Fc-epsilon Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of DNA Binding Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Secretion Mammary Gland Alveolus Development ERK1 And ERK2 Cascade Regulation Of Calcium Ion Import Negative Regulation Of Cholesterol Efflux Positive Regulation Of Hyaluronan Biosynthetic Process Regulation Of Protein Localization To Cell Surface Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Positive Regulation Of Protein Phosphorylation Transcription, DNA-templated Protein Phosphorylation Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Peripheral Nervous System Development Heart Development Neuromuscular Junction Development Motor Neuron Axon Guidance Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Cell Growth Positive Regulation Of Rho GTPase Activity Regulation Of Microtubule-based Process Negative Regulation Of Immature T Cell Proliferation In Thymus Fc-epsilon Receptor Signaling Pathway Wound Healing Myelination Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of Translation Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase III Promoter Protein Autophosphorylation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Oligodendrocyte Differentiation Positive Regulation Of Epithelial Cell Proliferation Regulation Of ERK1 And ERK2 Cascade
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease PIP3 activates AKT signaling Platelet degranulation Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants GRB2 events in ERBB2 signaling PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Response to elevated platelet cytosolic Ca2+ Innate Immune System Signaling by PDGF EGFR downregulation Signalling by NGF DAP12 interactions GAB1 signalosome GRB2 events in EGFR signaling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Inhibition of Signaling by Overexpressed EGFR Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR EGFR interacts with phospholipase C-gamma Signaling by ERBB2 Signaling by EGFR SHC1 events in EGFR signaling Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Constitutive Signaling by EGFRvIII Platelet activation, signaling and aggregation Adaptive Immune System	Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Axon guidance PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Signaling by SCF-KIT SHC1 events in ERBB2 signaling Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Sema4D in semaphorin signaling Sema4D induced cell migration and growth-cone collapse Innate Immune System Signaling by PDGF Downregulation of ERBB2:ERBB3 signaling Signalling by NGF DAP12 interactions GAB1 signalosome Semaphorin interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs		Sucralfate Alpha-Aminobutyric Acid	Trastuzumab Lapatinib ado-trastuzumab emtansine Pertuzumab Afatinib
Diseases
GWAS		Hair morphology ( 19896111)
Protein-Protein Interactions		12 interactors: ADAM12 ADRBK1 CPM DUSP3 EGFR ERBB2 ERBB3 GRB2 LMNA NRG1 PIK3R2 VTN	110 interactors: ABL1 ABL2 ACPP ANKS1A ANKS1B APBB1 APBB3 BCAR3 BLK BLNK BMX BTC CAV1 CBL CD82 CHN1 CISH CLNK CRK CRKL CTNNB1 DAB1 DLG4 DOK1 DOK4 DOK6 EGF EGFR ERBB2IP ERBB3 ERBB4 ERRFI1 ESR1 FER FGR GRAP2 GRB2 GRB7 HDAC6 HLA-A HSP90AA1 HSP90B1 IL6ST IRS1 IRS4 ITGA5 ITGB4 ITK JAK1 JAK2 JUP MAPK8IP1 MAPK8IP2 MATK MUC1 MUC4 NCK2 NF2 NRG1 PAK1 PICK1 PIK3C2A PIK3C2B PIK3R1 PIK3R2 PIK3R3 PLCG1 PLCG2 PTK2 PTK2B PTPN11 PTPN18 RASA1 RIN1 RIN2 SERPINA3 SH2B2 SH2B3 SH2D1B SH2D2A SH2D3A SH2D5 SH3BGRL3 SH3BP2 SHC1 SHC2 SHC3 SLA SLA2 SOCS1 SOS1 SRC SRPK1 STAT1 STAT3 STUB1 SUPT6H SYK TEC TGFA TLN1 TNS2 TNS3 TOB1 TXK UBB USP2 VAV1 VAV2 VAV3
Entrez ID		1950	2064
HPRD ID		00578	01281
Ensembl ID		ENSG00000138798	ENSG00000141736
Uniprot IDs		P01133	P04626
PDB IDs		1IVO 1JL9 1NQL 1P9J 2KV4 3NJP	1MFG 1MFL 1MW4 1N8Z 1OVC 1QR1 1S78 2A91 2JWA 2KS1 2L4K 3BE1 3H3B 3MZW 3N85 3PP0 3RCD 4GFU
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Innate Immune Response Enzyme Linked Receptor Protein Signaling Pathway Phosphatidylinositol-mediated Signaling Cellular Response To Growth Factor Stimulus Response To Growth Factor Fc-epsilon Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Phosphorylation Defense Response Regulation Of Immune Response Fc Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Cellular Response To Organic Substance Regulation Of Signal Transduction Regulation Of Kinase Activity Regulation Of Immune System Process Regulation Of Signaling Immune System Process Regulation Of Catalytic Activity Phosphatidylinositol 3-kinase Signaling Response To Stress Regulation Of Protein Phosphorylation Regulation Of Cell Adhesion Negative Regulation Of Signal Transduction Response To Organic Substance Anatomical Structure Development Negative Regulation Of Signaling Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Developmental Process Glial Cell Differentiation Positive Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process Positive Regulation Of Kinase Activity Regulation Of Peptidyl-tyrosine Phosphorylation Heart Development Positive Regulation Of Metabolic Process Gliogenesis	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Cell Communication Signaling Cell Surface Receptor Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Cellular Response To Stimulus Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Response To Stimulus Regulation Of Immune Response Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response Regulation Of Immune System Process Defense Response Immune System Process Cellular Response To Organic Substance Regulation Of Kinase Activity Regulation Of Phosphorylation Response To Stress Peptidyl-tyrosine Autophosphorylation Regulation Of Catalytic Activity Response To Organic Substance Cellular Response To Organonitrogen Compound Fc-epsilon Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Peptide Hormone Stimulus Regulation Of Cellular Process Cellular Response To Peptide Neurotrophin TRK Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Locomotion Neurotrophin Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Catalytic Activity Movement Of Cell Or Subcellular Component Cell Motility Cell Migration Wound Healing Response To Peptide Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cellular Response To Hormone Stimulus
Tagcloud ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prl prolactin pronounced putative rodents stat1 stat5 take ways	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Difference) ?		adulthood already autocrine cloned gh hyperplasia islet islets lactogen man mitotic motifs mutational neogenesis pancreas pl place placental preadipocyte pref pregnancy prl prolactin pronounced putative rodents stat1 stat5 take ways	12q 12q21 14q31 15q25 16q23 18p 19q13 20p12 20pq 20q12 21q21 3p14 4pq 5p14 5q14 6p12 7p12 8q23 cardia cdkn2 fist gej mlvi2 mts1 nrasl3 parentheses ptpn1 rca1 xpq xq25
Tagcloud (Intersection) ?