EEF2 and DISC1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		EEF2	DISC1
Gene Name		eukaryotic translation elongation factor 2	disrupted in schizophrenia 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Polysome Plasma Membrane Membrane Aggresome Ribonucleoprotein Complex Extracellular Vesicular Exosome	Mitochondrion Centrosome Microtubule Postsynaptic Density Cell Junction Ciliary Basal Body Postsynaptic Membrane
	Molecular Function	Translation Elongation Factor Activity GTPase Activity Protein Binding GTP Binding Translation Activator Activity Protein Kinase Binding Poly(A) RNA Binding	Protein Binding
	Biological Process	Hematopoietic Progenitor Cell Differentiation Translation Translational Elongation Pathogenesis Gene Expression Positive Regulation Of Gene Expression Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Translation	Microtubule Cytoskeleton Organization Neuron Migration Positive Regulation Of Neuroblast Proliferation Regulation Of Neuron Projection Development Cerebral Cortex Radially Oriented Cell Migration Cell Proliferation In Forebrain Positive Regulation Of Wnt Signaling Pathway TOR Signaling Cellular Protein Localization Mitochondrial Calcium Ion Homeostasis Canonical Wnt Signaling Pathway Regulation Of Synapse Maturation Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Pathways		Synthesis of diphthamide-EEF2 Uptake and actions of bacterial toxins Translation Post-translational protein modification Peptide chain elongation Eukaryotic Translation Elongation Gamma carboxylation, hypusine formation and arylsulfatase activation Uptake and function of diphtheria toxin
Drugs
Diseases
GWAS			Alzheimer's disease ( 19118814) Amyotrophic lateral sclerosis ( 19451621) Neuranatomic and neurocognitive phenotypes ( 21483430) Response to antineoplastic agents ( 21659360) Response to statin therapy ( 20339536)
Protein-Protein Interactions		16 interactors: CCT2 CDKN2A DISC1 EEF2K EEF2KMT HNRNPD MAPKAPK3 MLH1 NDRG1 PPM1A PPP2CA PPP2R1A PPP2R1B TP53 TRPM7 UCHL5	113 interactors: ACTG1 ACTN2 AGTPBP1 AKAP6 AKAP9 ARIH2 ATF4 ATF5 ATF7IP BICD1 BZRAP1 C14orf166 CCDC136 CCDC141 CCDC24 CCDC88A CDC5L CDK5RAP3 CEP170 CEP57L1 CEP63 CIT CLU COL4A1 DCTN1 DCTN2 DMD DNAJC7 DPYSL2 DPYSL3 DST DYNC1H1 EEF2 EIF3H EXOC1 EXOC4 EXOC7 FBXO41 FEZ1 FRYL GNB1 GNPTAB GPRASP2 HERC2P2 IFT20 IMMT ITSN1 KALRN KANSL1 KCNQ5 KIAA1377 KIF3A KIF3C KIFAP3 MACF1 MAP1A MATR3 MEMO1 MLLT10 MPPED1 MVP MYO1A MYT1L NDE1 NDEL1 NEFM NUP160 OLFM1 PAFAH1B1 PCNT PCNXL4 PDE4B PGK1 PPM1E PPP4R1 PPP5C RABGAP1 RAD21 RANBP9 RASSF7 RBSN ROGDI SH3BP5 SMARCE1 SMC2 SMC3 SNX6 SPARCL1 SPTAN1 SPTBN1 SPTBN4 SRGAP2 SRGAP3 STX18 SYBU SYNE1 TFIP11 TIAM2 TNIK TNKS TRAF3IP1 TRIO TUBB TUBB2A UTRN XPNPEP1 XRN2 YWHAE YWHAG YWHAQ YWHAZ ZNF197 ZNF365
Entrez ID		1938	27185
HPRD ID		00561	05553
Ensembl ID		ENSG00000167658	ENSG00000162946
Uniprot IDs		B4DPU3 P13639	C4P094 C4P096 C4P098 C4P0A4 C4P0A5 C4P0C4 C4P0C8 C4P0D0 C4P0D1 C4P0D2 C4P0D3 Q9NRI5
PDB IDs		3J3A
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Programmed Cell Death Regulation Of Protein Metabolic Process Cell Death Death Negative Regulation Of Cell Growth Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein RNA Catabolic Process Positive Regulation Of Cell Aging Positive Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of Signal Transduction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Growth Mitotic Nuclear Envelope Reassembly Apoptotic Process Cell Cycle Process Nuclear Envelope Reassembly Regulation Of Signaling Regulation Of Protein Phosphorylation Regulation Of Wnt Signaling Pathway Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Replicative Senescence Regulation Of Cell Growth Gene Expression Positive Regulation Of Protein Metabolic Process Regulation Of DNA Replication Cellular Response To Organic Substance Signaling Cell Communication Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Catalytic Activity Negative Regulation Of JAK-STAT Cascade Transforming Growth Factor Beta Receptor Signaling Pathway Cell Cycle Arrest Nuclear-transcribed MRNA Catabolic Process Cell Cycle MRNA Catabolic Process Cellular Macromolecule Catabolic Process Negative Regulation Of Cellular Metabolic Process Aromatic Compound Catabolic Process	Organelle Organization Movement Of Cell Or Subcellular Component Cellular Localization Microtubule-based Process Nervous System Development Establishment Of Localization In Cell Neurogenesis G2/M Transition Of Mitotic Cell Cycle Generation Of Neurons Microtubule Cytoskeleton Organization Cytoskeleton-dependent Intracellular Transport Mitotic Cell Cycle Process Cellular Component Assembly Cell Projection Organization Mitotic Cell Cycle Microtubule-based Transport Cell Cycle Process Organelle Localization Cytoskeleton Organization Cell Cycle Cell Projection Morphogenesis Cell Part Morphogenesis Anatomical Structure Development System Development Membrane Organization Cell Differentiation Cell Morphogenesis Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Organelle Transport Along Microtubule Developmental Process Protein Localization Microtubule-based Movement Axonogenesis Mitotic Nuclear Division Locomotion Establishment Of Organelle Localization Axon Guidance Vesicle Localization Axon Development Neuron Development Cellular Process Regulation Of Cellular Component Organization Multicellular Organismal Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Neurogenesis Cell Projection Assembly Neuron Differentiation Intracellular Transport Spindle Organization
Tagcloud ?		4e acutely alleviation assembly bps consequence consequent dephosphorylation eif2b eif4e eif4f elongation glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts translation untranslated utrs	accelerate aggregated allosteric amplify appropriated assemblies assembly biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Difference) ?		4e acutely alleviation bps consequence consequent dephosphorylation eif2b eif4e eif4f elongation glycogen initiation involve mrnas p70 phosphatidylinositol polypyrimidine ribosomal s6 signalling steps stimulates termed tracts translation untranslated utrs	accelerate aggregated allosteric amplify appropriated assemblies biochemically capsid catalytically collections commonality conceptualized continuum crowded exploit governed labile machines multimers multiprotein pathologically prions replicating replicative reprogrammed reset suited transmissibility
Tagcloud (Intersection) ?		assembly