E4F1 and UPF2

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		E4F1	UPF2
Gene Name		E4F transcription factor 1	UPF2 regulator of nonsense transcripts homolog (yeast)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Spindle	Nucleus Cytoplasm Cytosol Exon-exon Junction Complex Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Ligase Activity CAMP Response Element Binding Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Replication Transcription, DNA-templated Mitotic Nuclear Division Cell Proliferation Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Cell Cycle Process Viral Process Protein Ubiquitination Regulation Of Growth Cell Division Mitotic Cell Cycle Arrest	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Liver Development MRNA Export From Nucleus Gene Expression Organ Regeneration
Pathways			Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS			Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		14 interactors: ANP32A ATM ATR CDKN2A EHMT2 HMGA2 KRTAP10-4 KRTAP10-7 PRKDC RASSF1 RB1 SMAD9 TP53 UPF2	75 interactors: ABCF2 AGPAT1 ART4 ATP1B3 BLM CALR CENPU CIZ1 COMTD1 CYBA DCP1B DCP2 DPF2 E4F1 EIF1 EIF4A1 EIF4G1 ENO1 EXOSC1 EXOSC10 EXOSC4 EXOSC6 EXOSC8 GADD45GIP1 GLTSCR2 HBZ HMGA1 HS3ST3A1 HSF2BP ITGB1 KRT18 LDHA LSM1 MAP1A MAP1LC3B MIF MRPL40 MTERF3 MYB NDUFA7 NOB1 NOMO1 PHB2 PITX1 PUF60 RNPS1 RPL13 RPL5 RPL8 RPS15 RPS25 RPS6 RPS7 RRP7A RSRC2 SERBP1 SERF2 SKIV2L2 SMG1 SUMO3 TK1 TNNI2 TOP3B TUBB2A TYMS UPF1 UPF3B WNK1 XRN1 XRN2 ZBTB48 ZFP36 ZGPAT ZNF408 ZNF44
Entrez ID		1877	26019
HPRD ID		04317	10405
Ensembl ID		ENSG00000167967	ENSG00000151461
Uniprot IDs		Q66K89	Q9HAU5
PDB IDs			1UW4 2WJV
Enriched GO Terms of Interacting Partners?		Replicative Senescence Cell Cycle Process Cell Aging Cell Cycle Checkpoint Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Arrest Regulation Of Cell Cycle Process Cell Cycle Positive Regulation Of Cell Aging Regulation Of Signal Transduction By P53 Class Mediator Cell Cycle Arrest DNA Damage Checkpoint Response To Gamma Radiation Mitotic Cell Cycle Checkpoint Regulation Of Mitotic Cell Cycle Positive Regulation Of Response To DNA Damage Stimulus Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Cell Cycle Arrest Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Positive Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Cell Cycle Mitotic DNA Damage Checkpoint Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Mitotic DNA Integrity Checkpoint Nucleobase-containing Compound Metabolic Process Chromosome Organization Positive Regulation Of Cell Cycle Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Peptidyl-serine Phosphorylation Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Aging Cellular Senescence Cellular Nitrogen Compound Metabolic Process Regulation Of Response To DNA Damage Stimulus Mitotic Cell Cycle Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Response To Ionizing Radiation Intracellular Signal Transduction Chromatin Organization Negative Regulation Of Mitotic Cell Cycle Phase Transition Senescence-associated Heterochromatin Focus Assembly Double-strand Break Repair Mitotic Cell Cycle Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Senescence	Nuclear-transcribed MRNA Catabolic Process RNA Catabolic Process MRNA Catabolic Process Aromatic Compound Catabolic Process MRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Macromolecule Catabolic Process Gene Expression Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Catabolic Process Histone MRNA Catabolic Process RRNA Processing Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Translational Initiation Viral Process Ribosome Biogenesis Biosynthetic Process Histone MRNA Metabolic Process Cellular Metabolic Process Translational Termination Protein Complex Disassembly Translational Elongation RNA Biosynthetic Process Ribonucleoprotein Complex Biogenesis Cellular Protein Complex Disassembly Viral Transcription NcRNA Metabolic Process SRP-dependent Cotranslational Protein Targeting To Membrane Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Protein Localization To Endoplasmic Reticulum Viral Life Cycle Cytoplasmic Transport Metabolic Process Establishment Of Protein Localization To Membrane Translation Protein Targeting To Membrane Nuclear MRNA Surveillance Protein Localization To Membrane
Tagcloud ?		adenoviral arrest autophagy contributing coprecipitation databases derivative directed downregulate downregulation e1a g1 hbv hbx hcc hepatitis hepatocellular hepatocyte hepg2 interference marked multifunctional neutralize oncoprotein possibly public vacuolation vesicles viability	achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi
Tagcloud (Difference) ?		adenoviral arrest autophagy contributing coprecipitation databases derivative directed downregulate downregulation e1a g1 hbv hbx hcc hepatitis hepatocellular hepatocyte hepg2 interference marked multifunctional neutralize oncoprotein possibly public vacuolation vesicles viability	achieves bridge cenp centromere centromeres counteracted decay delocalization dispensable ebs1 extragenic fission interphase massive mis16 mis18 mis19 mis20 missegregation pombe recruiting schizosaccharomyces segregation sense snf snf22 snf5 sol1 swi
Tagcloud (Intersection) ?