E2F2 and BCAR1

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		E2F2	BCAR1
Gene Name		E2F transcription factor 2	breast cancer anti-estrogen resistance 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Transcription Factor Complex	Ruffle Nucleolus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Lamellipodium
	Molecular Function	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding	Signal Transducer Activity Protein Binding SH3 Domain Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Lens Fiber Cell Apoptotic Process	Regulation Of Cell Growth Actin Filament Organization Cell Adhesion Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Blood Coagulation Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Migration Cell Migration Platelet Activation Positive Regulation Of Cell Migration Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Apoptotic Process Platelet-derived Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Antigen Receptor-mediated Signaling Pathway T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Cell Division Cell Chemotaxis
Pathways		DNA Replication Pre-Initiation Cellular Senescence G1 Phase M/G1 Transition Regulation of DNA replication CDC6 association with the ORC:origin complex Oncogene Induced Senescence Cell Cycle, Mitotic Assembly of the pre-replicative complex Cyclin D associated events in G1 Oxidative Stress Induced Senescence Association of licensing factors with the pre-replicative complex Mitotic G1-G1/S phases	Signaling by PDGF Signaling by VEGF Downstream signal transduction p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling Platelet activation, signaling and aggregation Platelet Aggregation (Plug Formation) VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS			Crohn's disease (time to surgery) ( 23665963)
Protein-Protein Interactions		17 interactors: ARID3A ATAD2 BCAR1 BRD2 CDK3 FHL2 GIT2 GNB5 RB1 RNF144A RYBP SETD8 SP1 SPIB TFDP1 TFDP2 YY1	52 interactors: ABL1 AJUBA ARHGAP32 BMX CASP3 CD2AP CRK CRKL CSPG4 DOCK1 E2F2 EFS ESR1 FES FXYD6 FYB FYN GRB2 GSN HCK HSPA5 INPPL1 LCK LYN MMP14 NCK1 NEDD9 NPHP1 PIK3R1 PKD1 PPAP2B PPP1R15A PTK2 PTK2B PTPN1 PTPN12 PTPRA PTPRF PTPRH PXN RAN RAPGEF1 SH2D3A SH2D3C SH3KBP1 SRC SRCIN1 TRIP6 TUBA4A UHRF2 VPS11 YWHAZ
Entrez ID		1870	9564
HPRD ID		02692	04248
Ensembl ID		ENSG00000007968	ENSG00000050820
Uniprot IDs		Q14209	B2RBL9 B3KWE2 F5H855 P56945
PDB IDs		1N4M	1WYX 3T6G
Enriched GO Terms of Interacting Partners?		Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Enucleate Erythrocyte Differentiation Positive Regulation Of Cellular Biosynthetic Process Mitotic Cell Cycle Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cellular Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Division Positive Regulation Of Metabolic Process Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Androgen Receptor Signaling Pathway DNA-templated Transcription, Initiation Chromosome Organization Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Growth Factor Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Chromatin Modification Response To Growth Factor Negative Regulation Of Transcription, DNA-templated Sequestering Of Nodal From Receptor Via Nodal Binding Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Signal Transduction Peptidyl-tyrosine Autophosphorylation Signaling Cell Communication Cellular Response To Stimulus Response To Stimulus Cell Migration Cell Motility Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Platelet Activation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Locomotion Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Wounding ERBB Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Wound Healing Regulation Of Protein Kinase Activity Regulation Of Signal Transduction Cell Adhesion Regulation Of Cellular Component Organization Blood Coagulation Regulation Of Catalytic Activity Hemostasis Protein Autophosphorylation Positive Regulation Of Protein Metabolic Process Fc Receptor Signaling Pathway Innate Immune Response Response To Organonitrogen Compound Cellular Response To Organonitrogen Compound Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Phosphorylation Cellular Response To Peptide Hormone Stimulus Signal Complex Assembly Regulation Of Signaling
Tagcloud ?		accordingly acting collectively documented downregulates escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate stk40 subgroup supporting suppressive te undetectable upstream virtually	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		accordingly acting collectively documented downregulates escc esophageal exerted harbor heterogeneity inactive microrna micrornas mir negatively oncogenes p21 personalized pleiotropically reversed speculate stk40 subgroup supporting suppressive te undetectable upstream virtually	aldh1a1 anxa1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 mtdh ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?