E2F1 and RNF144A

Number of citations of the paper that reports this interaction (PMID 12411495)
72

Data Source:
BioGRID (two hybrid)

		E2F1	RNF144A
Gene Name		E2F transcription factor 1	ring finger protein 144A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Rb-E2F Complex	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Core Promoter Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Sequence-specific DNA Binding	Zinc Ion Binding Ligase Activity
	Biological Process	DNA Damage Checkpoint G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Notch Signaling Pathway Spermatogenesis Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Gene Expression Forebrain Development Anoikis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fibroblast Proliferation MRNA Stabilization Cellular Response To Fatty Acid Cellular Response To Hypoxia Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Lens Fiber Cell Apoptotic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle	Protein Ubiquitination
Pathways		Cellular Senescence Activation of BH3-only proteins Oncogene Induced Senescence Assembly of the pre-replicative complex Pre-NOTCH Transcription and Translation G2 Phase G1/S Transition G1/S-Specific Transcription Programmed Cell Death Pre-NOTCH Expression and Processing Mitotic G1-G1/S phases Intrinsic Pathway for Apoptosis E2F mediated regulation of DNA replication Signaling by NOTCH DNA Replication Pre-Initiation G1 Phase M/G1 Transition Regulation of DNA replication G0 and Early G1 CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Activation of NOXA and translocation to mitochondria Cyclin D associated events in G1 Oxidative Stress Induced Senescence Activation of PUMA and translocation to mitochondria Association of licensing factors with the pre-replicative complex Mitotic G2-G2/M phases Inhibition of replication initiation of damaged DNA by RB1/E2F1
Drugs
Diseases
GWAS			Response to antipsychotic treatment ( 20195266)
Protein-Protein Interactions		70 interactors: ARID3A ATAD2 ATM ATR BRCA1 BRD2 BTRC CCNA1 CCNA2 CDK1 CDK2 CDK3 CDK7 CDKN2A CEBPE CHEK2 CREBBP CTDP1 CUL1 DDB2 E2F6 ERCC3 FHL2 GSK3B GTF2H1 HCFC1 IGF1 KAT5 KDM1A MDM2 MDM4 MGA MNAT1 MYBL2 NCOA3 NCOA6 NCOR2 NDN NDNL2 NFKB1 NPDC1 NRIP1 PARP1 PHB PKIB PRDM2 PURA RARA RB1 RNF144A SERTAD2 SETD7 SKP2 SP1 SP2 SP3 SP4 SPIB STAT1 STOML1 TBP TEAD3 TFDP1 TFDP2 TOPBP1 TP53 TP53BP1 TRRAP VHL YWHAQ	13 interactors: E2F1 E2F2 E2F3 E2F4 PRKDC UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32
Entrez ID		1869	9781
HPRD ID		01806	11510
Ensembl ID		ENSG00000101412	ENSG00000151692
Uniprot IDs		Q01094 Q9BSD8	P50876
PDB IDs		1H24 1O9K 2AZE	1WIM
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of Metabolic Process Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Regulation Of Cell Cycle Negative Regulation Of Biosynthetic Process Cellular Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Process Cell Cycle Phase Transition Cellular Response To DNA Damage Stimulus Transcription Initiation From RNA Polymerase II Promoter Mitotic Cell Cycle Negative Regulation Of Transcription, DNA-templated Cell Cycle Mitotic Cell Cycle Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Cellular Process DNA Repair Cellular Response To Stress DNA-templated Transcription, Initiation Intracellular Steroid Hormone Receptor Signaling Pathway G1/S Transition Of Mitotic Cell Cycle	Protein Polyubiquitination Cellular Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Catabolic Process Lens Fiber Cell Apoptotic Process Intrinsic Apoptotic Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Catabolic Process Cellular Metabolic Process Apoptotic Signaling Pathway Mitotic Cell Cycle Positive Regulation Of Transcription, DNA-templated Cell Cycle Regulation Of Protein Catabolic Process Postreplication Repair Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein K11-linked Ubiquitination Positive Regulation Of Macromolecule Biosynthetic Process Proteolysis Cellular Protein Metabolic Process Positive Regulation Of Gene Expression Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Protein K63-linked Ubiquitination Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Protein K48-linked Ubiquitination Regulation Of Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Cellular Nitrogen Compound Metabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Proteasomal Protein Catabolic Process Cell Cycle Phase Transition Regulation Of Proteolysis Nitrogen Compound Metabolic Process Regulation Of DNA Repair Protein Metabolic Process
Tagcloud ?		box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike	catalytic cytoplasmic damage damaging dna e3 finger fingers induces insults interacts joining ligase ligases nonhomologous parc parkin persistent pk pkcs promotes prosurvival rbr reversed ring suffer ubiquitination vesicles
Tagcloud (Difference) ?		box coexpression consensus delays displaying dp dps e2fs ectopic emphasizes exit heterodimerization heterodimers lacks members namely pocket possesses possessing preference quiescent refer shares suppresses transactivational tttcccgc tttcgcgc unlike	catalytic cytoplasmic damage damaging dna e3 finger fingers induces insults interacts joining ligase ligases nonhomologous parc parkin persistent pk pkcs promotes prosurvival rbr reversed ring suffer ubiquitination vesicles
Tagcloud (Intersection) ?