DTX1 and UBE2U

Number of citations of the paper that reports this interaction (PMID 19690564)
33

Data Source:
BioGRID (two hybrid)

		DTX1	UBE2U
Gene Name		deltex 1, E3 ubiquitin ligase	ubiquitin-conjugating enzyme E2U (putative)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nuclear Chromatin Cytoplasm HULC Complex
	Molecular Function	Transcription Coactivator Activity Notch Binding Protein Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ubiquitin Protein Ligase Binding	ATP Binding Ligase Activity Ubiquitin-like Protein Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Regulation Of Notch Signaling Pathway Glial Cell Differentiation Protein Ubiquitination Negative Regulation Of T Cell Differentiation Negative Regulation Of Neuron Differentiation Regulation Of Nucleic Acid-templated Transcription	Protein Polyubiquitination DNA Repair Histone Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Activated NOTCH1 Transmits Signal to the Nucleus Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer FBXW7 Mutants and NOTCH1 in Cancer	Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System
Drugs
Diseases
GWAS		Visceral adipose tissue adjusted for BMI ( 22589738)
Protein-Protein Interactions		20 interactors: DEFA5 DTX2 DTX3 DTX3L EP300 G3BP1 GRB2 ITCH MAP3K1 NOTCH1 NOTCH2 TAX1BP3 UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2N UBE2U	66 interactors: ANAPC11 BARD1 BFAR CADPS2 CGRRF1 DTX1 DZIP3 GOLGA2 KAT6A MDM2 MIB1 MIB2 MID2 MKRN3 MUL1 PCGF1 PCGF2 PCGF6 PJA1 PML RBCK1 RNF10 RNF11 RNF113A RNF113B RNF114 RNF125 RNF139 RNF14 RNF144B RNF150 RNF166 RNF17 RNF170 RNF181 RNF2 RNF25 RNF26 RNF41 RNF5 RNFT1 SYVN1 TRAIP TRIM15 TRIM2 TRIM23 TRIM24 TRIM27 TRIM28 TRIM3 TRIM32 TRIM34 TRIM35 TRIM37 TRIM38 TRIM46 TRIM47 TRIM5 TRIM54 TRIM63 TRIM65 TRIM68 TRIM74 VPS11 VPS41 ZSWIM2
Entrez ID		1840	148581
HPRD ID		03991	14599
Ensembl ID		ENSG00000135144	ENSG00000177414
Uniprot IDs		Q86Y01	Q5VVX9
PDB IDs			1YRV
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Ubiquitination Protein Polyubiquitination Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Pattern Recognition Receptor Signaling Pathway Notch Signaling Pathway Innate Immune Response-activating Signal Transduction Immune Response Activation Of Innate Immune Response Defense Response Ubiquitin-dependent Protein Catabolic Process Cellular Protein Metabolic Process Modification-dependent Protein Catabolic Process Toll-like Receptor 4 Signaling Pathway Innate Immune Response Positive Regulation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Cellular Response To Hypoxia Protein Catabolic Process Cellular Response To Decreased Oxygen Levels Histone Ubiquitination Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Regulation Of Innate Immune Response Immune Response-regulating Signaling Pathway Cell Surface Receptor Signaling Pathway Cellular Response To Stress Protein Metabolic Process Cellular Response To Stimulus Cellular Macromolecule Catabolic Process Immune System Process Response To Stress Positive Regulation Of Ubiquitin-protein Transferase Activity Response To Stimulus Positive Regulation Of Ligase Activity Positive Regulation Of Immune Response Signal Transduction Regulation Of Ubiquitin-protein Transferase Activity Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Signaling Proteasomal Protein Catabolic Process Cell Communication Protein K63-linked Ubiquitination Mitotic Spindle Assembly Checkpoint	Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Protein Metabolic Process Regulation Of Viral Release From Host Cell Protein Polyubiquitination Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Viral Process Protein Catabolic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Innate Immune Response Proteasomal Protein Catabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Macromolecule Catabolic Process Regulation Of Protein Stability Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Histone H2A Monoubiquitination Regulation Of Gene Expression Histone H2A Ubiquitination Histone H2A-K119 Monoubiquitination Immune Response Regulation Of Intracellular Transport Cellular Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Defense Response Interferon-gamma-mediated Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Histone Monoubiquitination Negative Regulation Of Cellular Metabolic Process Regulation Of Viral Entry Into Host Cell Response To Stress Negative Regulation Of Viral Transcription Regulation Of Apoptotic Process Regulation Of RNA Metabolic Process Cellular Response To Interferon-gamma Protein Destabilization Regulation Of Signal Transduction
Tagcloud ?		algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx2 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Difference) ?		algae bioconversion diarrhetic dinophysistoxin dinophysistoxins distinctive distinguished dsp dtx2 dtxs eluted featured fragmentation imperative isomers mrm oa okadaic orbitrap poisoning polyether quick shellfish spectra toxins transitions unequivocal unless z
Tagcloud (Intersection) ?