DPP4 and CXCR4

Number of citations of the paper that reports this interaction (PMID 11278278)
10

Data Source:
HPRD (in vivo)

		DPP4	CXCR4
Gene Name		dipeptidyl-peptidase 4	chemokine (C-X-C motif) receptor 4
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Focal Adhesion Cell Surface Membrane Integral Component Of Membrane Apical Plasma Membrane Lamellipodium Endocytic Vesicle Lamellipodium Membrane Membrane Raft Intercellular Canaliculus Extracellular Vesicular Exosome Invadopodium Membrane	Cytoplasm Lysosome Early Endosome Late Endosome Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Growth Cone Cell Leading Edge Cytoplasmic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protease Binding Serine-type Endopeptidase Activity Receptor Binding Protein Binding Serine-type Peptidase Activity Dipeptidyl-peptidase Activity Identical Protein Binding Protein Homodimerization Activity	Virus Receptor Activity Actin Binding G-protein Coupled Receptor Activity Protein Binding Coreceptor Activity C-X-C Chemokine Receptor Activity Cytokine Binding Ubiquitin Protein Ligase Binding Myosin Light Chain Binding Ubiquitin Binding
	Biological Process	Response To Hypoxia Proteolysis Positive Regulation Of Cell Proliferation Negative Regulation Of Extracellular Matrix Disassembly T Cell Costimulation Regulation Of Cell-cell Adhesion Mediated By Integrin T Cell Activation Endothelial Cell Migration	Activation Of MAPK Activity Patterning Of Blood Vessels Response To Hypoxia Ameboidal-type Cell Migration Neuron Migration Dendritic Cell Chemotaxis Apoptotic Process Inflammatory Response G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Germ Cell Development Brain Development Motor Neuron Axon Guidance Germ Cell Migration Response To Virus Viral Process Calcium-mediated Signaling Entry Into Host Cell Regulation Of Cell Migration T Cell Proliferation Neutrophil Activation Myelin Maintenance Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Chemotaxis Neural Precursor Cell Proliferation Chemokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus
Pathways		Peptide hormone metabolism Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Incretin synthesis, secretion, and inactivation	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR HIV Infection Class A/1 (Rhodopsin-like receptors) GPCR ligand binding Metabolic disorders of biological oxidation enzymes Early Phase of HIV Life Cycle GPCR downstream signaling HIV Life Cycle Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events Binding and entry of HIV virion
Drugs		Atorvastatin Sitagliptin 2-Amino-3-Methyl-1-Pyrrolidin-1-Yl-Butan-1-One 5-(Aminomethyl)-6-(2,4-Dichlorophenyl)-2-(3,5-Dimethoxyphenyl)Pyrimidin-4-Amine Alpha-D-Mannose (2s)-Pyrrolidin-2-Ylmethylamine Iodo-Phenylalanine Diisopropylphosphono Group 1-(1-phenylcyclopentyl)methylamine (S)-2-[(R)-3-amino-4-(2-fluorophenyl)butyryl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide Vildagliptin Alogliptin Saxagliptin (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-PROP-1-YN-1-YLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE N-(TRANS-4-{(1S,2S)-2-AMINO-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-1-METHYL-3-OXOPROPYL}CYCLOHEXYL)-N-METHYLACETAMIDE (2S,3S)-4-cyclopropyl-3-{(3R,5R)-3-[2-fluoro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazolidin-5-yl}-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxobutan-2-amine (2S,3S)-3-{3-[2-chloro-4-(methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-cyclopentylidene-4-cyclopropyl-1-fluorobutan-2-amine (3R,4R)-4-(pyrrolidin-1-ylcarbonyl)-1-(quinoxalin-2-ylcarbonyl)pyrrolidin-3-amine (7R,8R)-8-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydroimidazo[1,2-a:4,5-c\']dipyridin-7-amine (2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE (1S,2R,5S)-5-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-2-(2,4,5-TRIFLUOROPHENYL)CYCLOHEXANAMINE (2R)-4-[(8R)-8-METHYL-2-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[1,5-A]PYRAZIN-7(8H)-YL]-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE (2S,3S)-3-AMINO-4-(3,3-DIFLUOROPYRROLIDIN-1-YL)-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-6-YLCYCLOHEXYL)BUTANAMIDE (2S,3S)-3-AMINO-4-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-N,N-DIMETHYL-4-OXO-2-(TRANS-4-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-5-YLCYCLOHEXYL)BUTANAMIDE (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE 4\'-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide (2R,3R)-7-(methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine 7-(aminomethyl)-6-(2-chlorophenyl)-1-methyl-1H-benzimidazole-5-carbonitrile (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-(2,2,2-TRIFLUOROETHYL)-1,4-DIAZEPAN-2-ONE METHYL 4-{[({[(2R,5S)-5-{[(2S)-2-(AMINOMETHYL)PYRROLIDIN-1-YL]CARBONYL}PYRROLIDIN-2-YL]METHYL}AMINO)CARBONYL]AMINO}BENZOATE (1S)-2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-1-CYCLOPENTYL-2-OXOETHANAMINE 1-biphenyl-2-ylmethanamine (1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile (2R)-N-[(2R)-2-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-N-[(5R)-5-(DIHYDROXYBORYL)-1-L-PROLYLPYRROLIDIN-2-YL]-L-PROLINAMIDE (3R,4S)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE N-({(2S)-1-[(3R)-3-AMINO-4-(2-FLUOROPHENYL)BUTANOYL]PYRROLIDIN-2-YL}METHYL)BENZAMIDE (4R,5R)-5-AMINO-1-[2-(1,3-BENZODIOXOL-5-YL)ETHYL]-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-2-ONE (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE 1-[2-(S)-AMINO-3-BIPHENYL-4-YL-PROPIONYL]-PYRROLIDINE-2-(S)-CARBONITRILE (1S,6R)-3-{[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]CARBONYL}-6-(2,4,5-TRIFLUOROPHENYL)CYCLOHEX-3-EN-1-AMINE (2R)-4-(2-BENZOYL-1,2-DIAZEPAN-1-YL)-4-OXO-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE (3R,4R)-1-{6-[3-(METHYLSULFONYL)PHENYL]PYRIMIDIN-4-YL}-4-(2,4,5-TRIFLUOROPHENYL)PIPERIDIN-3-AMINE 2-(4-{(3S,5S)-5-[(3,3-difluoropyrrolidin-1-yl)carbonyl]pyrrolidin-3-yl}piperazin-1-yl)pyrimidine N-({(2S)-1-[(3R)-3-amino-4-(3-chlorophenyl)butanoyl]pyrrolidin-2-yl}methyl)-3-(methylsulfonyl)benzamide (3R,4S)-1-[6-(6-METHOXYPYRIDIN-3-YL)PYRIMIDIN-4-YL]-4-(2,4,5-TRIFLUOROPHENYL)PYRROLIDIN-3-AMINE 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM 7-BENZYL-1,3-DIMETHYL-8-PIPERAZIN-1-YL-3,7-DIHYDRO-PURINE-2,6-DIONE 2-({2-[(3R)-3-AMINOPIPERIDIN-1-YL]-4-OXOQUINAZOLIN-3(4H)-YL}METHYL)BENZONITRILE 4-[(3R)-3-{[2-(4-FLUOROPHENYL)-2-OXOETHYL]AMINO}BUTYL]BENZAMIDE 2-({8-[(3R)-3-AMINOPIPERIDIN-1-YL]-1,3-DIMETHYL-2,6-DIOXO-1,2,3,6-TETRAHYDRO-7H-PURIN-7-YL}METHYL)BENZONITRILE Linagliptin	Framycetin Plerixafor
Diseases
GWAS		Hippocampal volume ( 22504421)	Multiple sclerosis ( 19525953) Telomere length ( 20421499)
Protein-Protein Interactions		16 interactors: ADA CCL11 CCL22 CCL3L1 CCL5 CD4 CPAMD8 CXCL10 CXCL11 CXCL12 CXCL9 CXCR4 DKK1 FAP GRP PTPRC	32 interactors: ADRBK2 ARRB2 ATP13A2 CCR5 CD4 CTSG CXCL12 DPP4 ELANE GNA13 GNAI1 HLA-C HSPA8 ITCH JAK1 JAK2 JAK3 MYBL2 MYH9 PTK2 PTPN11 PTPN6 PTPRC SDC4 SOCS1 SOCS3 STAT1 STAT2 STAT3 STAT5B USP14 VAV1
Entrez ID		1803	7852
HPRD ID		02187	01217
Ensembl ID		ENSG00000197635	ENSG00000121966
Uniprot IDs		P27487	P61073
PDB IDs		1J2E 1N1M 1NU6 1NU8 1PFQ 1R9M 1R9N 1RWQ 1TK3 1TKR 1U8E 1W1I 1WCY 1X70 2AJL 2BGN 2BGR 2BUB 2FJP 2G5P 2G5T 2G63 2HHA 2I03 2I78 2IIT 2IIV 2JID 2OAG 2OGZ 2OLE 2ONC 2OPH 2OQI 2OQV 2P8S 2QJR 2QKY 2QOE 2QT9 2QTB 2RGU 2RIP 3BJM 3C43 3C45 3CCB 3CCC 3D4L 3EIO 3F8S 3G0B 3G0C 3G0D 3G0G 3H0C 3HAB 3HAC 3KWF 3KWJ 3NOX 3O95 3O9V 3OC0 3OPM 3Q0T 3Q8W 3QBJ 3SWW 3SX4 3VJK 3VJL 3VJM 3W2T 4A5S 4DSA 4DSZ 4DTC 4G1F 4JH0 4KR0 4L72 4LKO	2K03 2K04 2K05 3ODU 3OE0 3OE6 3OE8 3OE9
Enriched GO Terms of Interacting Partners?		Cell Chemotaxis Cell Migration Locomotion Chemotaxis Cell Motility Chemokine-mediated Signaling Pathway Response To Virus Response To Other Organism Response To Biotic Stimulus Regulation Of Behavior Regulation Of Cell Migration Leukocyte Chemotaxis Response To External Stimulus Regulation Of Cell Motility Regulation Of Leukocyte Migration Inflammatory Response Regulation Of Locomotion Regulation Of Cellular Component Movement Movement Of Cell Or Subcellular Component Regulation Of Chemotaxis Immune System Process Positive Regulation Of Leukocyte Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Immune Response Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Defense Response Positive Regulation Of Leukocyte Migration Positive Regulation Of Calcium Ion Transport Regulation Of Cell Proliferation Leukocyte Migration Positive Regulation Of Chemotaxis Positive Regulation Of Behavior Positive Regulation Of Intracellular Signal Transduction T Cell Chemotaxis Regulation Of Intracellular Signal Transduction Leukocyte Cell-cell Adhesion Positive Regulation Of Immune System Process Response To Stress Positive Regulation Of CAMP-mediated Signaling Regulation Of Calcium Ion Transport Regulation Of Signal Transduction Positive Regulation Of Ion Transport Lymphocyte Chemotaxis Response To Cytokine T Cell Migration Positive Regulation Of T Cell Migration Cytokine-mediated Signaling Pathway Regulation Of T Cell Migration	Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Immune Response Regulation Of Immune System Process Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Stress Defense Response JAK-STAT Cascade Cytokine-mediated Signaling Pathway Immune System Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Immune Response Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Innate Immune Response Regulation Of Cell-cell Adhesion Locomotion Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Cytokine Regulation Of Type I Interferon-mediated Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Response To Organic Substance Response To Peptide Hormone Regulation Of Cell Adhesion Innate Immune Response Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Peptide Signaling Movement Of Cell Or Subcellular Component Response To Type I Interferon Cell Migration Positive Regulation Of Cell Adhesion Cell Communication Response To External Stimulus Cell Activation Positive Regulation Of Immune System Process Interferon-gamma-mediated Signaling Pathway Cell Motility Response To Stimulus Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Cellular Response To Interferon-gamma Regulation Of Signal Transduction Signal Transduction Cellular Response To Organic Substance Response To Interferon-gamma
Tagcloud ?		albuminuria ameliorate bioavailability capability dipeptidyl english experimentally glp indirectly insufficient interfere journals language march microalbuminuria microangiopathy microvascular modifying nephropathy neuropathy nonincretin peer peptidase preliminary retinopathy retrieved scanned ulcer	capture ccr1 ccr2 ccr5 ccr7 cd40 chemokine chemokines cxcr1 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Difference) ?		albuminuria ameliorate bioavailability capability dipeptidyl english experimentally glp indirectly insufficient interfere journals language march microalbuminuria microangiopathy microvascular modifying nephropathy neuropathy nonincretin peer peptidase preliminary retinopathy retrieved scanned ulcer	capture ccr1 ccr2 ccr5 ccr7 cd40 chemokine chemokines cxcr1 dc dendritic ebi1 elc immature inflamed insight lost lymphoid marginally maturation mature maturing migrate nodes organs phases respective responded responsiveness
Tagcloud (Intersection) ?