DNMT3A and ZBTB18

Number of citations of the paper that reports this interaction (PMID 11350943)
103

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		DNMT3A	ZBTB18
Gene Name		DNA (cytosine-5-)-methyltransferase 3 alpha	zinc finger and BTB domain containing 18
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Chromosome, Centromeric Region Euchromatin XY Body Nucleus Nucleoplasm Nuclear Heterochromatin Cytoplasm Nuclear Matrix	Nuclear Chromosome Nucleus Nucleoplasm Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	DNA Binding Chromatin Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding DNA-methyltransferase Activity Identical Protein Binding Unmethylated CpG Binding Metal Ion Binding DNA (cytosine-5-)-methyltransferase Activity, Acting On CpG Substrates	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Methylation-dependent Chromatin Silencing Regulation Of Gene Expression By Genetic Imprinting Spermatogenesis DNA Methylation On Cytosine Within A CG Sequence Gene Expression DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Hypermethylation Of CpG Island Negative Regulation Of Gene Expression, Epigenetic S-adenosylhomocysteine Metabolic Process S-adenosylmethioninamine Metabolic Process Cellular Response To Amino Acid Stimulus C-5 Methylation Of Cytosine	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription, DNA-templated Skeletal Muscle Tissue Development Cerebellum Development Hippocampus Development Cerebral Cortex Development Negative Regulation Of Transcription, DNA-templated Neuron Development Homeostasis Of Number Of Cells Regulation Of Cell Division
Pathways		Chromatin modifying enzymes Chromatin organization Epigenetic regulation of gene expression PRC2 methylates histones and DNA RMTs methylate histone arginines DNA methylation
Drugs
Diseases
GWAS		Crohn's disease ( 21102463) Height ( 18391951) Type 1 diabetes ( 21980299)
Protein-Protein Interactions		31 interactors: CBX1 DNMT1 DNMT3B DNMT3L EED EHMT1 EHMT2 EZH2 F8A1 HDAC1 HIST1H3A HIST1H3E MYC NRIP1 PIAS1 PRMT5 PTGES3 RB1 RPS8 SETDB1 SP100 SPI1 SUMO1 SUV39H1 TCL1A TERF2IP UBE2I UHRF1 USP7 ZBTB17 ZBTB18	7 interactors: CTBP1 CTBP2 DNMT3A DNMT3B PAK1 POMGNT1 TSN
Entrez ID		1788	10472
HPRD ID		04141	12231
Ensembl ID		ENSG00000119772	ENSG00000179456
Uniprot IDs		Q9Y6K1	Q99592
PDB IDs		2QRV 3A1A 3A1B 3LLR 3SVM
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Chromosome Organization Chromatin Organization Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression, Epigenetic DNA Methylation On Cytosine Chromatin Modification DNA Methylation Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression, Epigenetic Nucleobase-containing Compound Metabolic Process Methylation DNA Modification Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Organelle Organization Regulation Of Transcription From RNA Polymerase II Promoter Histone Modification Gene Expression DNA Metabolic Process Peptidyl-lysine Modification RNA Biosynthetic Process Histone Methylation Regulation Of Metabolic Process Transcription, DNA-templated Histone H3-K9 Modification Protein Methylation Cellular Macromolecule Biosynthetic Process RNA Metabolic Process Regulation Of Chromosome Organization Macromolecule Biosynthetic Process Histone H3-K9 Methylation Maintenance Of DNA Methylation Cellular Metabolic Process Histone Lysine Methylation Peptidyl-lysine Methylation Chromatin Silencing Peptidyl-amino Acid Modification	S-adenosylmethioninamine Metabolic Process DNA Methylation On Cytosine Within A CG Sequence C-5 Methylation Of Cytosine S-adenosylhomocysteine Metabolic Process Methylation-dependent Chromatin Silencing DNA Methylation On Cytosine White Fat Cell Differentiation Chromatin Modification Viral Genome Replication Chromatin Organization Regulation Of Gene Expression By Genetic Imprinting Chromatin Silencing Genetic Imprinting Regulation Of Transcription From RNA Polymerase II Promoter Gene Expression Chromosome Organization DNA Methylation Cellular Response To Amino Acid Stimulus Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Organelle Organization Positive Regulation Of Histone Modification Negative Regulation Of Gene Expression, Epigenetic Cellular Response To Organonitrogen Compound DNA Modification Negative Regulation Of Chromosome Organization Negative Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter By Histone Modification Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Gene Silencing Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Response To Amino Acid Cellular Nitrogen Compound Metabolic Process Fat Cell Differentiation Regulation Of Histone Modification Negative Regulation Of Cell Proliferation Nitrogen Compound Metabolic Process Cellular Response To Acid Chemical Negative Regulation Of Transcription From RNA Polymerase II Promoter Hypermethylation Of CpG Island Response To Organonitrogen Compound Viral Life Cycle Negative Regulation Of Cell Proliferation Involved In Contact Inhibition Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Regulation Of Chromosome Organization Regulation Of Gene Expression, Epigenetic Positive Regulation Of Chromatin Binding
Tagcloud ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Difference) ?		cpg cues de dense dnmt1 dnmts enhancers ensure ensures establishment excluded guide lethal localize methylated methylation methylome methyltransferase methyltransferases novo nucleosomes observe preferential promoters pwwp reflects setd2 transcribed
Tagcloud (Intersection) ?