DLST and DLG5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		DLST	DLG5
Gene Name		dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	discs, large homolog 5 (Drosophila)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrial Matrix Membrane Oxoglutarate Dehydrogenase Complex Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Cell-cell Adherens Junction
	Molecular Function	Dihydrolipoyllysine-residue Succinyltransferase Activity	Protein Binding Beta-catenin Binding Cytoskeletal Protein Binding Receptor Signaling Complex Scaffold Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Tricarboxylic Acid Cycle Lysine Catabolic Process L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Small Molecule Metabolic Process	Protein Complex Assembly Signal Transduction Negative Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Polarized Epithelial Cell Differentiation Midbrain Development Intracellular Signal Transduction Regulation Of Apoptotic Process Apical Protein Localization Zonula Adherens Assembly Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Epithelial Tube Branching Involved In Lung Morphogenesis Protein Localization To Adherens Junction Metanephric Collecting Duct Development
Pathways		Lysine catabolism Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport Metabolism of amino acids and derivatives Citric acid cycle (TCA cycle)
Drugs
Diseases
GWAS		Non-small cell lung cancer ( 23144319)	Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Obesity-related traits ( 23251661)
Protein-Protein Interactions		15 interactors: ARIH2 CCDC86 DLG5 FLII NAP1L1 NDRG1 OGDH PAK4 PFN2 RUSC2 SCFD1 TUBB4B UMPS ZBTB16 ZHX1	8 interactors: ABCA1 BTBD10 CD81 CTNNB1 DLST PFN1 SORBS3 TERF1
Entrez ID		1743	9231
HPRD ID		00520	04972
Ensembl ID		ENSG00000119689	ENSG00000151208
Uniprot IDs		B7Z6J1 P36957	Q8TDM6
PDB IDs			1UIT
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Organelle Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cytoskeleton Organization Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Phosphorylation Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Organelle Organization Regulation Of Protein Complex Assembly Positive Regulation Of Metabolic Process Regulation Of Stress Fiber Assembly Regulation Of Chromosome Segregation Positive Regulation Of MAPK Cascade Positive Regulation Of 1-phosphatidylinositol 4-kinase Activity Response To Drug Regulation Of Phosphorylation Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Schwann Cell Proliferation Cellular Response To Insulin-like Growth Factor Stimulus Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Protein Polymerization Regulation Of MAPK Cascade Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Cardiac Outflow Tract Cell Proliferation Renal Inner Medulla Development Renal Outer Medulla Development Mesenchymal Cell Proliferation Involved In Lung Development L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine Telomeric Loop Formation Glial Cell Fate Determination Age-dependent Telomere Shortening Oviduct Development Regulation Of Centriole-centriole Cohesion Embryonic Epithelial Tube Formation Epithelial Tube Formation Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Determination Of Dorsal Identity Telomere Maintenance Via Telomere Shortening Lung Induction Interleukin-1 Beta Secretion Embryonic Skeletal Limb Joint Morphogenesis Canonical Wnt Signaling Pathway Involved In Regulation Of Cell Proliferation Tube Formation Cell Proliferation Morphogenesis Of Embryonic Epithelium
Tagcloud ?		acneiform aphtha b51 began behcet believe chorioretinopathy deteriorate eruption erythema gradual granulomas granulomatous hypopyon infliximab interstitial nephritis nodosum november occasionally prednisolone psl reportedly sarcoidosis sometimes spasmodic stated transferred uveitis	12b 18rap 23r atg16l1 card15 card9 ccr6 crohn dmbt1 holds homeostatic ibd5 icoslg irf5 irgm itln1 loci lrrk2 mst1 nkx2 orchestration predispose ptger4 ptpn2 ptpn22 tl1a tnfrsf6b tnfsf15 xbp1
Tagcloud (Difference) ?		acneiform aphtha b51 began behcet believe chorioretinopathy deteriorate eruption erythema gradual granulomas granulomatous hypopyon infliximab interstitial nephritis nodosum november occasionally prednisolone psl reportedly sarcoidosis sometimes spasmodic stated transferred uveitis	12b 18rap 23r atg16l1 card15 card9 ccr6 crohn dmbt1 holds homeostatic ibd5 icoslg irf5 irgm itln1 loci lrrk2 mst1 nkx2 orchestration predispose ptger4 ptpn2 ptpn22 tl1a tnfrsf6b tnfsf15 xbp1
Tagcloud (Intersection) ?