DDX3X and NFKB2

Number of citations of the paper that reports this interaction (PMID 14743216)
197

Data Source:
HPRD (in vitro)

		DDX3X	NFKB2
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked	nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
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Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrial Outer Membrane Eukaryotic Translation Initiation Factor 3 Complex Cytoplasmic Stress Granule Nuclear Speck Cytosolic Small Ribosomal Subunit Extracellular Vesicular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Bcl3/NF-kappaB2 Complex
	Molecular Function	DNA Binding RNA Binding GTPase Activity ATP-dependent DNA Helicase Activity ATP-dependent RNA Helicase Activity Protein Binding ATP Binding Transcription Factor Binding Poly(A) Binding Eukaryotic Initiation Factor 4E Binding ATPase Activity Nucleoside-triphosphatase Activity Translation Initiation Factor Binding RNA Stem-loop Binding Ribosomal Small Subunit Binding CTPase Activity Poly(A) RNA Binding MRNA 5'-UTR Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Transcription, DNA-templated Chromosome Segregation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Virus RNA Secondary Structure Unwinding Positive Regulation Of Gene Expression Viral Process Negative Regulation Of Translation Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Protein Complex Assembly DNA Duplex Unwinding Positive Regulation Of Interferon-beta Production Stress Granule Assembly Intracellular Signal Transduction Mature Ribosome Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Translational Initiation Cellular Response To Arsenic-containing Substance Cellular Response To Osmotic Stress Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Intrinsic Apoptotic Signaling Pathway Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway Follicular Dendritic Cell Differentiation Germinal Center Formation MyD88-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Cytokine Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Toll-like Receptor 10 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Toll Like Receptor 7/8 (TLR7/8) Cascade RIP-mediated NFkB activation via ZBP1 Toll Like Receptor TLR6:TLR2 Cascade DEx/H-box helicases activate type I IFN and inflammatory cytokines production Toll Like Receptor TLR1:TLR2 Cascade Activated TLR4 signalling MyD88 cascade initiated on plasma membrane Toll Like Receptor 5 (TLR5) Cascade ZBP1(DAI) mediated induction of type I IFNs MyD88 dependent cascade initiated on endosome MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Toll Like Receptor 9 (TLR9) Cascade Innate Immune System TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Cytokine Signaling in Immune system MyD88-independent cascade Toll Like Receptor 2 (TLR2) Cascade RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Signaling by Interleukins Toll Like Receptor 10 (TLR10) Cascade Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Interleukin-1 processing TRAF6 mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: APBB1 CSNK2A1 IL7R NEDD4 NFKB2 NUP62 PIN1 SREK1 WBP4 XPO1 YWHAQ ZNF512B	35 interactors: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		1654	4791
HPRD ID		02154	01239
Ensembl ID		ENSG00000215301	ENSG00000077150
Uniprot IDs		O00571	Q00653
PDB IDs		2I4I 2JGN 3JRV	1A3Q 2D96 3DO7
Enriched GO Terms of Interacting Partners?		Response To Cytokine Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Metabolic Process Cytokine-mediated Signaling Pathway Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Signal Transduction Cellular Response To Cytokine Stimulus Regulation Of Cellular Component Organization Signaling Regulation Of Transcription, DNA-templated Cell Communication Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Cell Cycle Regulation Of Protein Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Thymidylate Synthase Biosynthetic Process Transmission Of Virus Development Involved In Symbiotic Interaction Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Organic Substance Regulation Of Organelle Organization Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Cellular Response To Stimulus Follicular Dendritic Cell Differentiation Interleukin-7-mediated Signaling Pathway Regulation Of Intracellular Transport Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Type I Interferon Production Cell Death Death Cellular Response To Organic Substance Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Signal Transduction Negative Regulation Of Transcription, DNA-templated Regulation Of Cell Cycle Process MRNA Transport Regulation Of Mitotic Nuclear Division Negative Regulation Of Nucleic Acid-templated Transcription	I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Immune System Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 3 Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Type I Interferon Production Activation Of Innate Immune Response Gene Expression Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Toll-like Receptor 5 Signaling Pathway RNA Metabolic Process Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Regulation Of Type I Interferon Production Toll-like Receptor Signaling Pathway Transcription, DNA-templated TRIF-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Innate Immune Response MyD88-independent Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Inflammatory Response Pattern Recognition Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Innate Immune Response-activating Signal Transduction Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Macromolecule Biosynthetic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Negative Regulation Of Gene Expression Intracellular Signal Transduction
Tagcloud ?		aberrations amplifications cdkn2a concordant cul3 ddr2 differs entities epha2 exonic fgfr fgfr1 fgfr2 fgfr3 harbored harbors hnscc locoregionally makeup massively mll2 mutational notch1 nsd1 papilloma pik3ca s249c targetable therapeutically	arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable
Tagcloud (Difference) ?		aberrations amplifications cdkn2a concordant cul3 ddr2 differs entities epha2 exonic fgfr fgfr1 fgfr2 fgfr3 harbored harbors hnscc locoregionally makeup massively mll2 mutational notch1 nsd1 papilloma pik3ca s249c targetable therapeutically	arrangement bcl cbcl cbcls clonal clonality cls ctcl ctcls cutaneous deletions extranodal germline hodgkin ig lymphoid lymphomas lyt malignancies neoplasias nodal oncogenes pathogenetic rearrangement rearrangements southern tal tcr undetectable
Tagcloud (Intersection) ?