DDX1 and NDRG1

Number of citations of the paper that reports this interaction (PMID 17220478)
17

Data Source:
HPRD (in vivo)

		DDX1	NDRG1
Gene Name		DEAD (Asp-Glu-Ala-Asp) box helicase 1	N-myc downstream regulated 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytoplasmic Stress Granule Membrane Ribonucleoprotein Complex Cleavage Body TRNA-splicing Ligase Complex	Nucleus Cytoplasm Centrosome Cytosol Microtubule Plasma Membrane Cell-cell Adherens Junction Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding Chromatin Binding Transcription Cofactor Activity RNA Helicase Activity Double-stranded RNA Binding Nuclease Activity Exonuclease Activity Protein Binding ATP Binding ATP-dependent Helicase Activity Poly(A) Binding DNA/RNA Helicase Activity Poly(A) RNA Binding	Protein Binding Microtubule Binding Rab GTPase Binding Gamma-tubulin Binding Cadherin Binding
	Biological Process	Spliceosomal Complex Assembly Double-strand Break Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated TRNA Splicing, Via Endonucleolytic Cleavage And Ligation Regulation Of Translational Initiation Multicellular Organismal Development Response To Virus DNA Duplex Unwinding Response To Exogenous DsRNA Nucleic Acid Phosphodiester Bond Hydrolysis	Response To Metal Ion DNA Damage Response, Signal Transduction By P53 Class Mediator Peripheral Nervous System Myelin Maintenance Mast Cell Activation Cellular Response To Hypoxia Positive Regulation Of Spindle Checkpoint
Pathways
Drugs
Diseases
GWAS		Chronic kidney disease ( 22479191) Pulmonary function ( 21946350) Pulmonary function (interaction) ( 23284291) Wilms tumor ( 22544364)	Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		8 interactors: APP ATM CSTF2 HNRNPK NDRG1 NME7 RELA YWHAQ	64 interactors: ACSL3 ACTG1 AP1M2 AP2M1 ARL4D ATP1A1 CANX CDH1 CLTC CNDP2 COPB2 CTNNB1 DDX1 DDX5 DLST EEF1G EEF2 EIF2S3 EIF3E EWSR1 FASN HNRNPF HNRNPH1 HNRNPU HSD17B4 HSP90AA1 HSPA5 ILF3 KIF5B LDHA MAOA MLH1 MME NCL PABPC1 PHYHIP PKM PPP2R2A PRKACA PSMC2 PSMC3 PSMD2 RPL24 RPL3 RPL4 RPN2 RPS16 RPS20 RPS26 RPS3 RPS6 RPS8 RUVBL2 S100B SEC23A SGK1 SHMT2 TAF9 TARS TLE3 UPF1 VCP XRCC5 ZNF155
Entrez ID		1653	10397
HPRD ID		03158	05586
Ensembl ID		ENSG00000079785	ENSG00000104419
Uniprot IDs		A3RJH1 Q92499	Q8N959 Q92597
PDB IDs
Enriched GO Terms of Interacting Partners?		MRNA Metabolic Process Nervous System Development MRNA Polyadenylation Positive Regulation Of Cell Cycle Process RNA Polyadenylation Brain Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Head Development Positive Regulation Of Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Neuron Apoptotic Process Signal Transduction Central Nervous System Development Neuron Death Response To Abiotic Stimulus Signaling MRNA Processing DNA Damage Response, Signal Transduction By P53 Class Mediator Cell Communication MRNA 3'-end Processing Response To Radiation Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint Acetaldehyde Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process RNA 3'-end Processing System Development Signal Transduction By P53 Class Mediator Negative Regulation Of Protein Catabolic Process Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Synaptic Growth At Neuromuscular Junction Positive Regulation Of Schwann Cell Differentiation RNA Processing Cellular Response To Stimulus Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Collateral Sprouting In Absence Of Injury Regulation Of Schwann Cell Differentiation Nucleobase-containing Compound Metabolic Process Cell Activation Multicellular Organismal Development Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Low-density Lipoprotein Particle Receptor Biosynthetic Process Response To Cobalamin Anatomical Structure Development Pre-B Cell Allelic Exclusion Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process MRNA Metabolic Process Gene Expression Cellular Metabolic Process Cellular Macromolecule Catabolic Process Membrane Organization Protein Localization To Endoplasmic Reticulum SRP-dependent Cotranslational Protein Targeting To Membrane Catabolic Process Cotranslational Protein Targeting To Membrane Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Aromatic Compound Catabolic Process Viral Process Translational Initiation Establishment Of Protein Localization To Membrane Translational Elongation Cellular Nitrogen Compound Metabolic Process Viral Transcription Translation Nitrogen Compound Metabolic Process Establishment Of Localization In Cell Cellular Localization Cellular Protein Localization Protein Targeting To Membrane Biosynthetic Process Establishment Of Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Translational Termination Protein Localization Protein Localization To Membrane Protein Localization To Organelle Cellular Protein Metabolic Process Cellular Macromolecule Biosynthetic Process Protein Targeting Macromolecule Biosynthetic Process Protein Transport Cellular Protein Complex Disassembly RNA Metabolic Process Viral Life Cycle Cytoplasmic Transport Protein Complex Disassembly Intracellular Transport Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process
Tagcloud ?		apply asp clcn7 complementation complementing disequilibrium erb ercc1 erythroblastic exo1 exonuclease gwas helicase inconsistent nominal perfect phosphoprotein prerequisite reexamined replicate replicating rs2844484 rs2857602 spp1 stringent swedish tmc6 tmc8 underscore	4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw
Tagcloud (Difference) ?		apply asp clcn7 complementation complementing disequilibrium erb ercc1 erythroblastic exo1 exonuclease gwas helicase inconsistent nominal perfect phosphoprotein prerequisite reexamined replicate replicating rs2844484 rs2857602 spp1 stringent swedish tmc6 tmc8 underscore	4ebp1 allosteric bid dosing dysregulated es ewing integrates liposarcoma master mln0128 mtorc1 mtorc2 osteosarcoma pakt pan promise rapalogues rapamycin reactivation rhabdomyosarcoma rms sarcoma schedule schedules sheath striking synovial tiw
Tagcloud (Intersection) ?