DDIT3 and C14orf80

Number of citations of the paper that reports this interaction (PMID 20562859)
242

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		DDIT3	C14orf80
Gene Name		DNA-damage-inducible transcript 3	chromosome 14 open reading frame 80
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Late Endosome Cytosol CHOP-C/EBP Complex
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Blood Vessel Maturation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus ER Overload Response Response To Unfolded Protein Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Wnt Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Interleukin-8 Production Response To Endoplasmic Reticulum Stress Response To Starvation MRNA Transcription From RNA Polymerase II Promoter Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Neuron Apoptotic Process Regulation Of DNA-templated Transcription In Response To Stress Cellular Protein Metabolic Process Regulation Of Transcription Involved In Anterior/posterior Axis Specification Cell Redox Homeostasis Negative Regulation Of Myoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Negative Regulation Of Determination Of Dorsal Identity
Pathways		ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperones ATF6-alpha activates chaperone genes Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		57 interactors: AMOTL2 ATF2 ATF3 ATF4 ATPAF2 BACH1 BACH2 BATF BATF2 BATF3 C11orf30 C14orf80 CCDC153 CDK6 CEBPB CEBPE CEBPG CREB3 CREB3L1 CSNK2A1 DBP DGCR2 EP300 EPAS1 F2 FOS FOSL1 FOSL2 GIPC1 GP1BA HOXA5 HSD17B14 IKBKG JUN JUNB JUND KPNA2 LMO2 MAFF MAFG MAPK14 MCMBP NFIL3 PICALM POLR1D RAI1 RPS3A SNAPC5 SPOP SRA1 SSX3 TNFSF12 TRIB3 VPS37C ZBTB25 ZC3H14 ZSCAN31	1 interactors: DDIT3
Entrez ID		1649	283643
HPRD ID		00529	12658
Ensembl ID		ENSG00000175197	ENSG00000185347
Uniprot IDs		P35638 Q53YD1	Q86SX3
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Biosynthetic Process Transcription, DNA-templated Gene Expression RNA Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune System Process Cellular Metabolic Process Regulation Of Cellular Process Response To Endoplasmic Reticulum Stress Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Hemopoiesis Response To Stress Immune System Development Developmental Process Response To Other Organism Leukocyte Differentiation Anatomical Structure Development Response To Biotic Stimulus Circadian Rhythm Cellular Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Defense Response Toll-like Receptor 5 Signaling Pathway Organ Development Toll-like Receptor 10 Signaling Pathway System Development	Negative Regulation Of Determination Of Dorsal Identity Regulation Of Transcription Involved In Anterior/posterior Axis Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress ER Overload Response MRNA Transcription From RNA Polymerase II Promoter Blood Vessel Maturation MRNA Transcription Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Negative Regulation Of Myoblast Differentiation Positive Regulation Of Interleukin-8 Production Release Of Sequestered Calcium Ion Into Cytosol Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Regulation Of Sequestering Of Calcium Ion Regulation Of Myoblast Differentiation Negative Regulation Of Muscle Cell Differentiation Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Neuron Apoptotic Process Anterior/posterior Axis Specification Positive Regulation Of Neuron Death Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Axis Specification Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Redox Homeostasis Response To Unfolded Protein Cell Cycle Arrest Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Muscle Cell Differentiation Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Endoplasmic Reticulum Stress Regulation Of Ion Homeostasis Response To Starvation Cytosolic Calcium Ion Homeostasis Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Regulation Of Canonical Wnt Signaling Pathway Regulation Of Neuron Apoptotic Process Anterior/posterior Pattern Specification Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Wnt Signaling Pathway Regulation Of Neuron Death Cellular Calcium Ion Homeostasis
Tagcloud ?		a5 aapoaii advance aggregated amyloid amyloidosis apoa2c apolipoprotein atf4 atf6 atg5 deposition deposits doi eif2ak3 extracellularly fibril fibrils hspa5 intravenously labinvest online p1 protecting publication r1 senile unfolded xbp1s
Tagcloud (Difference) ?		a5 aapoaii advance aggregated amyloid amyloidosis apoa2c apolipoprotein atf4 atf6 atg5 deposition deposits doi eif2ak3 extracellularly fibril fibrils hspa5 intravenously labinvest online p1 protecting publication r1 senile unfolded xbp1s
Tagcloud (Intersection) ?